Protein Alignment Pi4KIIalpha and Pi4k2a

DIOPT Version :10

• Sequence 1: NP_730944.2
• Gene: Pi4KIIalpha / 40670
• FlyBaseID: FBgn0037339
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: XP_038963964.1
• Gene: Pi4k2a / 114554
• RGDID: 620485
• Length: 480
• Species: Rattus norvegicus
• Alignment Length: 513
• Identity: 234/513 - (45%)
• Similarity: 289/513 - (56%)
• Gaps: 138/513 - (26%)

  Fly   209 PEIDFEGMS--------------TDAGS---------DNRESQPLLGGGNASHGSRISELLGGLG 250
            ||..|..:|              ..|||         .:||.||||           ....|...
  Rat    16 PEYTFPSVSGAHFPQVPGGAVRVAAAGSGPSPPCSPGHDRERQPLL-----------DRARGAAA 69

  Fly   251 RGHDH----------------VEFVS-----NTFGDDPLFSEIVAKAEGAIENGVLPERIYQGSS 294
            :|..|                |..|.     |.|.:||.|..:|.:||.|||..:.|||||||||
  Rat    70 QGQTHTVAAQAQALAAQAAVAVHAVQTHRERNDFPEDPEFEVVVRQAEIAIECSIYPERIYQGSS 134

  Fly   295 GSYFVKDASHQCLAVFKPKDEEPYGRLNPKWTKWMHKLCCPCCFGRACLIPNQGYLSESGASLVD 359
            |||||||:..:.:||||||:|||||.||||||||:.||||||||||.||:.|||||||:||||||
  Rat   135 GSYFVKDSQGRIIAVFKPKNEEPYGNLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVD 199

  Fly   360 RKLNLNVVPKTRVVRLVAESFNYARIDRQKAKLKKRIKEHYPSA--HFNRMSLPLKTGSFQLFVE 422
            :||.||:||:|:||.|.:|:|||:.|||.|::.|:...|..|..  .|||:.||.|.||||||||
  Rat   200 QKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVE 264

  Fly   423 GYKDADYWLRRFESEPLPPSVAKSFQLQFERLVVLDYIIRNTDRGNDNWLIKYVAPKITTQVGGT 487
            |||||||||||||:||||.:..:...|||||||||||||||||||||||||||..|.
  Rat   265 GYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIKYDYPM-------- 321

  Fly   488 GGRTMHGVVTPKLPNALGASKIVDLNEPPQASPKPTTGGRPSNHLAGGAATSAQQDSSSLASSED 552
                                                                            |
  Rat   322 ----------------------------------------------------------------D 322

  Fly   553 EPSSRSPPTSEPDWNVVNSAFIRIAAIDNGLAFPFKHPDSWRAYPYHWAWLPQAKIPFSEEIKEQ 617
            .|:.|     :.||.:|....|::||||||||||.||||||||||::||||||||:|||:|||:.
  Rat   323 NPNCR-----DTDWVMVREPVIKVAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDL 382

  Fly   618 VLPQLSDMNFVEEICTELLYLFQQDRGFDKRLFERQMSVMRGQI----LNLTQALRDG 671
            :||::||.|||:::..:|..||::|.|||:..|.:|::|||||:    |:.::.|..|
  Rat   383 ILPKISDPNFVKDLEEDLYELFKKDPGFDRGQFHKQIAVMRGQVFEPFLHQSKELTSG 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIalpha	NP_730944.2	Protein Kinases, catalytic domain	292..>474	CDD:473864	130/183 (71%)
Pi4k2a	XP_038963964.1	PI3_PI4_kinase	132..426	CDD:395364	195/370 (53%)