Protein Alignment LYN and BCK1

DIOPT Version :9

• Sequence 1: XP_011515831.1
• Gene: LYN / 4067
• HGNCID: 6735
• Length: 682
• Species: Homo sapiens
• Sequence 2: NP_012440.1
• Gene: BCK1 / 853350
• SGDID: S000003631
• Length: 1478
• Species: Saccharomyces cerevisiae
• Alignment Length: 728
• Identity: 168/728 - (23%)
• Similarity: 263/728 - (36%)
• Gaps: 208/728 - (28%)

Human   100 PPSGLNMQIRAP------GSSWDL--SAEPRDSQFLSRRAGPRCRS--LPGRGASGPDALQPPAR 154
            |..|..:.|..|      .||:.:  ..|..:..|..||..|..:.  .|.|.|..|.|...|.|
Yeast   755 PDKGSKLNIPTPITENESKSSFQVLRKDEGTEIDFNHRRESPYTKPELAPKREAPKPPANTSPQR 819

Human   155 G-------------------KRGGRATPGPAP--AAPRRASS------VPGQQPPHTQVLLGRPV 192
            .                   .|..|:.|.|..  ::|..|||      .....|..|.||:.:|.
Yeast   820 TLSTSKQNKPIRLVRASTKISRSKRSKPLPPQLLSSPIEASSSSPDSLTSSYTPASTHVLIPQPY 884

Human   193 ------------------APPTL---------NSS--------HRGAPPPRNFHRERVPESQLLP 222
                              ..|:|         ||:        :..:|..:..:.:||..|.
Yeast   885 KGANDVMRRLKTDQDSTSTSPSLKMKQKVNRSNSTVSTSNSIFYSPSPLLKRGNSKRVVSST--- 946

Human   223 GQRFQTKDPEEQGDIVVALYP--YDGIHPDDLSF--------------------KKGEKMKVLEE 265
                ...|..|:.||..|..|  :|....||.|.                    ||.||......
Yeast   947 ----SAADIFEENDITFADAPPMFDSDDSDDDSSSSDDIIWSKKKTAPETNNENKKDEKSDNSST 1007

Human   266 HGEW----WKAKSLLTKKEGFIPSNYVAKLNTLETEEWFF------KDITRKDAE-------RQL 313
            |.:.    .:.:..:.:|..|.||..|...|.    |.||      |.||...|.       ..|
Yeast  1008 HSDEIFYDSQTQDKMERKMTFRPSPEVVYQNL----EKFFPRANLDKPITEGIASPTSPKSLDSL 1068

Human   314 LAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMI 378
            |:|.|      :..|.|...:.|      .||..|....: |:...||......:...|..:..|
Yeast  1069 LSPKN------VASSRTEPSTPS------RPVPPDSSYEF-IQDGLNGKNKPLNQAKTPKRTKTI 1120

Human   379 KHYQKQADGLCRRLEKACISPKPQ--KPWDKDAWEIPRE---SIKLVKR---------------L 423
            :....:| .|.|   |..:..|.|  |.|.....|:...   ||...|.               :
Yeast  1121 RTIAHEA-SLAR---KNSVKLKRQNTKMWGTRMVEVTENHMVSINKAKNSKGEYKEFAWMKGEMI 1181

Human   424 GAGQFGEVWMGYYNNST--KVAVKTLKPGTMS---------VQAFLEEANLMKTLQHDKLVRLYA 477
            |.|.||.|:: ..|.:|  .:|||.::....|         |:|...|.:.:|.|.|..:|:...
Yeast  1182 GKGSFGAVYL-CLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLG 1245

Human   478 VVTREEPIYIITEYMAKGSLLDFLKS----DEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDL 538
            ...:.....:..||:|.||:...::.    ||      |.:...:.|:.:|:||:..|..:|||:
Yeast  1246 FENKNNIYSLFLEYVAGGSVGSLIRMYGRFDE------PLIKHLTTQVLKGLAYLHSKGILHRDM 1304

Human   539 RAANVLVSESLMCKIADFGLARVIED---NEYTAREGAKFPIKWTAPEAINF--GCFTIKSDVWS 598
            :|.|:|:.:..:|||:|||::|..:|   |......|..|   |.|||.::.  | ::.|.|:||
Yeast  1305 KADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVF---WMAPEMVDTKQG-YSAKVDIWS 1365

Human   599 FGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKM-----------CWKE 652
            .|.::.|:.. ||.|:   :|.:|:.|:   :::.:.::.|....|.:.:           |::.
Yeast  1366 LGCIVLEMFA-GKRPW---SNLEVVAAM---FKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEI 1423

Human   653 KAEERPTFDYLQS 665
            ..|:|||.:.|.|
Yeast  1424 NPEKRPTANELLS 1436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LYN	XP_011515831.1	SH3_Lyn	237..292	CDD:212937	17/80 (21%)
		SH2_Src_Lyn	295..395	CDD:198227	25/112 (22%)
		PTKc_Lyn	409..680	CDD:270657	78/306 (25%)
		Pkinase_Tyr	417..667	CDD:285015	76/295 (26%)
BCK1	NP_012440.1	STKc_Bck1_like	1173..1440	CDD:270799	74/282 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910