Protein Alignment LYN and lyn

DIOPT Version :9

• Sequence 1: XP_011515831.1
• Gene: LYN / 4067
• HGNCID: 6735
• Length: 682
• Species: Homo sapiens
• Sequence 2: NP_001004543.1
• Gene: lyn / 447804
• ZFINID: ZDB-GENE-040912-7
• Length: 510
• Species: Danio rerio
• Alignment Length: 488
• Identity: 373/488 - (76%)
• Similarity: 422/488 - (86%)
• Gaps: 18/488 - (3%)

Human   195 PTLNSSHRGAPPPRNFHRERVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEK 259
            |.:.|.:.|                |||||.||..  ||:..||||||||:.||.|||.||||||
Zfish    41 PPITSQNAG----------------LLPGQVFQKM--EEKEKIVVALYPYEAIHADDLGFKKGEK 87

Human   260 MKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFL 324
            :|::|||||||||:||.|:|||||||||||:.:|:||||||:|||||||||||||||.|..|::|
Zfish    88 LKIIEEHGEWWKARSLTTRKEGFIPSNYVAEADTMETEEWFYKDITRKDAERQLLAPANKPGSYL 152

Human   325 IRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLC 389
            ||||||.|||:|||:||.|....||:|||||||||||||||||:|||..||.|||||.||:||||
Zfish   153 IRESETSKGSYSLSIRDVDAQGQDVVKHYKIRSLDNGGYYISPKITFSDISSMIKHYHKQSDGLC 217

Human   390 RRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSV 454
            |:|:|||..||.|||||||||||.::|||:||:|||||||||||.:|||||||||||||||||||
Zfish   218 RKLDKACEKPKAQKPWDKDAWEISKDSIKMVKKLGAGQFGEVWMAFYNNSTKVAVKTLKPGTMSV 282

Human   455 QAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSA 519
            :|||||||||||||||:|||||||||:.|||||||||||.|||||||||..|.|:.|||||||||
Zfish   283 EAFLEEANLMKTLQHDRLVRLYAVVTKTEPIYIITEYMANGSLLDFLKSQAGSKIQLPKLIDFSA 347

Human   520 QIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEA 584
            ||||||||||:|||||||||||||||||.|:||||||||||||||::||||||||||||||||||
Zfish   348 QIAEGMAYIEKKNYIHRDLRAANVLVSEMLLCKIADFGLARVIEDDQYTAREGAKFPIKWTAPEA 412

Human   585 INFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMC 649
            ||:|.||||||:||||:|||||:|||||||||.:|::||:::.:||||||.||||.|||:||..|
Zfish   413 INYGSFTIKSDMWSFGVLLYEIITYGKIPYPGMSNSEVMSSVQRGYRMPRPENCPVELYEIMTTC 477

Human   650 WKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 682
            ||.|.|:||||||:|||||||||||||||||||
Zfish   478 WKNKPEDRPTFDYIQSVLDDFYTATEGQYQQQP 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LYN	XP_011515831.1	SH3_Lyn	237..292	CDD:212937	43/54 (80%)
		SH2_Src_Lyn	295..395	CDD:198227	76/99 (77%)
		PTKc_Lyn	409..680	CDD:270657	225/270 (83%)
		Pkinase_Tyr	417..667	CDD:285015	207/249 (83%)
lyn	NP_001004543.1	SH3_Lyn	65..120	CDD:212937	43/54 (80%)
		SH2_Src_Lyn	123..223	CDD:198227	76/99 (77%)
		PTKc_Lyn	237..508	CDD:270657	225/270 (83%)
		Pkinase_Tyr	245..495	CDD:285015	207/249 (83%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194335094
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55649
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D151662at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10566
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	8	8.330