DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LYN and src-1

DIOPT Version :9

Sequence 1:	XP_011515831.1	Gene:	LYN / 4067	HGNCID:	6735	Length:	682	Species:	Homo sapiens
Sequence 2:	NP_001364829.1	Gene:	src-1 / 171722	WormBaseID:	WBGene00005077	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	460	Identity:	216/460 - (46%)
Similarity:	302/460 - (65%)	Gaps:	16/460 - (3%)

- Green bases have known domain annotations that are detailed below.

Human   233 EQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHG-EWWKAKSLLTKKEGFIPSNYVAKLNTLET 296
            ::.:.:|||||||.....||||:||:.|.:|:... :||..:...|.:.|::|.|:|||..|:|:
Worm    75 QERETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIES 139

Human   297 EEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPV-HGDVIKHYKIRSLDN 360
            |||:...|.|..|||.:|:.....|.|||||.|.....|:|::||.|.. :|..:|||||:.||:
Worm   140 EEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDH 204

Human   361 G-GYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWD-----KDAWEIPRESIKL 419
            . ||:|:.|.||..:.:::::|....||||.:|........|.:| |     :..|||||..:.|
Worm   205 DQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRP-DLSHDTQQNWEIPRNQLHL 268

Human   420 VKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEP 484
            .::||.|.|||||.|.:....:||:||:||||||.:|||:||.:||...|..||:||||.|||||
Worm   269 KRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTREEP 333

Human   485 IYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESL 549
            .|||||||..||||.:|::| |..:.:..|:|.:||||.||.|:|.:..:||||.|.||||.:.:
Worm   334 FYIITEYMINGSLLQYLRTD-GSTLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKI 397

Human   550 ----MCKIADFGLAR-VIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTY 609
                :.|:||||||| ::|::.|.||.|||||||||||||...|.||:||||||:|||||||:|.
Worm   398 SGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTK 462

Human   610 GKIPYPGRTNADVMTALSQGYRMPRVENCPDELY-DIMKMCWKEKAEERPTFDYLQSVLDDFYTA 673
            |::||||..|.:|:..:..|||||....||:::| :::..||.:..:.|||||.|....||::.:
Worm   463 GQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVS 527

Human   674 TEGQY 678
            |:..|
Worm   528 TQPNY 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LYN	XP_011515831.1	SH3_Lyn	237..292	CDD:212937	24/55 (44%)
		SH2_Src_Lyn	295..395	CDD:198227	42/101 (42%)
		PTKc_Lyn	409..680	CDD:270657	146/276 (53%)
		Pkinase_Tyr	417..667	CDD:285015	137/255 (54%)
src-1	NP_001364829.1	SH3_Src_like	79..130	CDD:212779	20/50 (40%)
		SH2_Src_family	138..240	CDD:199827	42/101 (42%)
		PTKc_Src_like	270..522	CDD:270630	136/252 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I713
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	513	1.000	Inparanoid score	I772
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm15767
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.870