Protein Alignment Snm1 and DCLRE1C

DIOPT Version :10

• Sequence 1: NP_649548.1
• Gene: Snm1 / 40669
• FlyBaseID: FBgn0037338
• Length: 763
• Species: Drosophila melanogaster
• Sequence 2: NP_001029027.1
• Gene: DCLRE1C / 64421
• HGNCID: 17642
• Length: 692
• Species: Homo sapiens
• Alignment Length: 573
• Identity: 125/573 - (21%)
• Similarity: 223/573 - (38%)
• Gaps: 152/573 - (26%)

  Fly   291 YFLTHFHADHYIGL------------TKKFCHPLYVSPISARLVRTFIKLD--ETHIHEIDVDQT 341
            |||:|.|.||..||            .|.:   ||.||::..|:.|..|..  :..|..|:::..
Human    29 YFLSHCHKDHMKGLRAPTLKRRLECSLKVY---LYCSPVTKELLLTSPKYRFWKKRIISIEIETP 90

  Fly   342 LDV----------DGVQVTALEANHCPGALMFFFKLSSGECILHTGDFR----ASADMESLPIFW 392
            ..:          :.:.||.|.|.||||::||.|:.::| .:|:|||||    .:|.||.|....
Human    91 TQISLVDEASGEKEEIVVTLLPAGHCPGSVMFLFQGNNG-TVLYTGDFRLAQGEAARMELLHSGG 154

  Fly   393 NHSNIDLLYLDTTYMN-KNYDFCHQSESVDRAVDLVRAFLEKNAAKRILIVCGSYVIGKEKIWLA 456
            ...:|..:|||||:.: :.|....:.|.:...::|||:::.::....:.:.|.: ..|.|.::..
Human   155 RVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVWLNCKA-AYGYEYLFTN 218

  Fly   457 LAKEFTMRVWTESNRSTAVRCLNWPDLDSVLTEDRSGANLHVIAMGKISYPSLVDYFTEFEDQYD 521
            |::|..::|  ..|:....|  |.|::...||.||: ..:|.     ..:|...:||     |:.
Human   219 LSEELGVQV--HVNKLDMFR--NMPEILHHLTTDRN-TQIHA-----CRHPKAEEYF-----QWS 268

  Fly   522 ML--------------LGIRPSG-W--EKNSKPSYGKRI--STIGIEYSEHSSYKELERFVRFLK 567
            .|              :.|:||. |  |::.|.:...|.  |:....:|.||||.|::.|:.:|.
Human   269 KLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYLC 333

  Fly   568 PKRVI-STVPVGRDLYVTGEVPIRWYKYEGRASMLRTGFQPSISTFLATPKRAFAKFSADTEMFL 631
            |.... :.:|||..:....|:                             .:...:.|..||...
Human   334 PVNAYPNVIPVGTTMDKVVEI-----------------------------LKPLCRSSQSTEPKY 369

  Fly   632 SPVDE-----NASKGSEDKKD---DDRESVVPTNH--------------VTIISD--------TP 666
            .|:.:     ...:.||::.|   || ...:|..|              :|.:|:        ||
Human   370 KPLGKLKRARTVHRDSEEEDDYLFDD-PLPIPLRHKVPYPETFHPEVFSMTAVSEKQPEKLRQTP 433

  Fly   667 ----EECFQT---------DSKIPVKNEPLAPDTSPNSEI--VAQLNAMESEIPYVEI------D 710
                .||.|:         :.......|.:....|...::  |..|...:.::|..|:      :
Human   434 GCCRAECMQSSRFTNFVDCEESNSESEEEVGIPASLQGDLGSVLHLQKADGDVPQWEVFFKRNDE 498

  Fly   711 IKNETIA--PDAVLIPRVPTEDTFQSTDCNVIGVQKSQAVVVSRLTSDASDDW 761
            |.:|::.  |.:.:.....:...|..:|.....:....:...:.:|...|..|
Human   499 ITDESLENFPSSTVAGGSQSPKLFSDSDGESTHISSQNSSQSTHITEQGSQGW 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snm1	NP_649548.1	SNM1A-1C-like_MBL-fold	252..408	CDD:293831	47/144 (33%)
		DRMBL	481..578	CDD:429512	29/116 (25%)
DCLRE1C	NP_001029027.1	artemis-SNM1C-like_MBL-fold	1..171	CDD:293855	47/145 (32%)
		DRMBL	239..345	CDD:429512	29/116 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	504..555		6/48 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..664