Protein Alignment Snm1 and INTS9

DIOPT Version :10

• Sequence 1: NP_649548.1
• Gene: Snm1 / 40669
• FlyBaseID: FBgn0037338
• Length: 763
• Species: Drosophila melanogaster
• Sequence 2: NP_001349967.1
• Gene: INTS9 / 55756
• HGNCID: 25592
• Length: 676
• Species: Homo sapiens
• Alignment Length: 680
• Identity: 126/680 - (18%)
• Similarity: 214/680 - (31%)
• Gaps: 241/680 - (35%)

  Fly   128 TTSSAFTGKLDAKPSEKRVQPSRRAKGKENASLSEVHVIDLCSEDEQTIKRKPSAIASPCEKSSD 192
            |..:.|||.:.|  :|..||..|.                |..|....|:|.|.|.::...|:.|
Human   114 TEHTGFTGTVYA--TEPTVQIGRL----------------LMEELVNFIERVPKAQSASLWKNKD 160

  Fly   193 VQATKFRTPETSMPEAKLSNSSL-DLVEISPGPNKSPTNNFYRSSPAAITKESPLGKNSKKGTVR 256
            :|              :|..|.| |.||:|.          :|.........|.|.|....|..:
Human   161 IQ--------------RLLPSPLKDAVEVST----------WRRCYTMQEVNSALSKIQLVGYSQ 201

  Fly   257 KQRKPKPCPPYKVVEGTSFCVDGFQFGEIEGVTHYFLTHFHADHYI-GLTKKFCHPLYVSPISAR 320
            |      ...:..|:.|... .|:..|....:..   :|:....|: |.:....||   .|:...
Human   202 K------IELFGAVQVTPLS-SGYALGSSNWIIQ---SHYEKVSYVSGSSLLTTHP---QPMDQA 253

  Fly   321 LVRTFIKLDETHIHEIDVDQTLDVDGV-----QVTALEANHCPGALMFFFKLSSG------ECIL 374
            .::....|..|.:.:|   .|.:.||:     ...||...:....|:..:  .||      ||:.
Human   254 SLKNSDVLVLTGLTQI---PTANPDGMVGEFCSNLALTVRNGGNVLVPCY--PSGVIYDLLECLY 313

  Fly   375 HTGDFRASADMESLPIFWNHSNIDLLYLDTTYMNKNYDF--------CHQSESVDRAVDLVRAFL 431
            ...|   ||.:.|:|          ||..:...|.:.:|        ||..:|        :.:|
Human   314 QYID---SAGLSSVP----------LYFISPVANSSLEFSQIFAEWLCHNKQS--------KVYL 357

  Fly   432 -----------EKNAAKRILIVCGSY----------VIGKEKIWLALAKEFTMRVWTESNRST-- 473
                       :.|..|....:.|.:          ..|...:.......| |.:|.:|:.:|
Human   358 PEPPFPHAELIQTNKLKHYPSIHGDFSNDFRQPCVVFTGHPSLRFGDVVHF-MELWGKSSLNTVI 421

  Fly   474 ------------------AVRC--------LNWPDLDSVLTEDRSGANLHVIAMGKISYPSLVDY 512
                              |::|        ||:..:..:|.|.:.   |||:...:.:.|....
Human   422 FTEPDFSYLEALAPYQPLAMKCIYCPIDTRLNFIQVSKLLKEVQP---LHVVCPEQYTQPPPAQ- 482

  Fly   513 FTEFEDQYDMLLGIRPSGWEKNSKPSYGKRISTIGIEYSEHSSYKELERFVRFLKPKRVISTVPV 577
                ..:.|:::..:|...      || :|...:.:.:...  |:::|     :.|:...|.||:
Human   483 ----SHRMDLMIDCQPPAM------SY-RRAEVLALPFKRR--YEKIE-----IMPELADSLVPM 529

  Fly   578 GRDLYVTGEVPIRWYKYEGRASMLRTGFQPSISTFLATPKRAFAKFSADTEMFLSPVDENA--SK 640
                    |:                  :|.||  |||.....  .:.|.:..|.|....|  :.
Human   530 --------EI------------------KPGIS--LATVSAVL--HTKDNKHLLQPPPRPAQPTS 564

  Fly   641 GSEDKKDDDRESVVPTNHVTIISDTPEECFQTDSKIPVKNEPLAPDTSPNSEIVAQLNAMES--E 703
            |.:.|:..|              |.|      |.|:   .:||...:.|..:.|..|..:..  .
Human   565 GKKRKRVSD--------------DVP------DCKV---LKPLLSGSIPVEQFVQTLEKISQMCS 606

  Fly   704 IPYVEI----------DIKNETIAPDAVLI 723
            :|...:          |||.|..|...:::
Human   607 LPSPPLSFLLEQHGFSDIKVEDTAKGHIVL 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snm1	NP_649548.1	SNM1A-1C-like_MBL-fold	252..408	CDD:293831	32/167 (19%)
		DRMBL	481..578	CDD:429512	17/96 (18%)
INTS9	NP_001349967.1	Int9-like_MBL-fold	1..265	CDD:293852	42/205 (20%)
		Beta-Casp	307..425	CDD:214983	24/139 (17%)