DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppp2r1ba and Pp2A-29B

DIOPT Version :9

Sequence 1:	NP_001299846.1	Gene:	ppp2r1ba / 406685	ZFINID:	ZDB-GENE-040426-2700	Length:	589	Species:	Danio rerio
Sequence 2:	NP_001245944.1	Gene:	Pp2A-29B / 2768940	FlyBaseID:	FBgn0260439	Length:	650	Species:	Drosophila melanogaster

Alignment Length:	586	Identity:	434/586 - (74%)
Similarity:	499/586 - (85%)	Gaps:	2/586 - (0%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MAGADS--DDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRTELLPFLTDTIYDED 63
            ||.:|.  ||||||||||||||:||||||||||||||||||||||.||||:||:||||:||||||
  Fly     1 MAASDKSVDDSLYPIAVLIDELKNEDVQLRLNSIKKLSTIALALGEERTRSELIPFLTETIYDED 65

Zfish    64 EVLLALAEQLGNFTMLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRKISHEHSPVDLEVHF 128
            |||||||:||||||.||||||:...|:|||||||||||||||||||||||.::.|||..|||:|.
  Fly    66 EVLLALADQLGNFTSLVGGPEFAMYLIPPLESLATVEETVVRDKAVESLRTVAAEHSAQDLEIHV 130

Zfish   129 EPLVKRLASGDWFTSRTSACGLFSVCYPRVSSTVKAEIRQHFRTLCSDDTPMVRRAAASKLGEFA 193
            .|.::||.||||||||||||||||||||||:..||||:|.:||.||.|:|||||||||:||||||
  Fly   131 VPTLQRLVSGDWFTSRTSACGLFSVCYPRVTQPVKAELRANFRKLCQDETPMVRRAAANKLGEFA 195

Zfish   194 KVLELEYVKSDIISLFTALASDEQDSVRLLAVEAGVSIATLLPQEDLEALVMPTLRQAAEDKSWR 258
            ||:|.||:|||:|..|..||.|:|||||||||||.||||.||||:|:|.||:|||||.|.|.|||
  Fly   196 KVVETEYLKSDLIPNFVQLAQDDQDSVRLLAVEACVSIAQLLPQDDVEHLVLPTLRQCASDSSWR 260

Zfish   259 VRYMVADKFSDLQKAVGPEITKNDLVPAFQNLLKDCEAEVRAAAANKVKEFCENLPEDSRETIIM 323
            ||||||:||.|||||||||||:.|||||||.||||.|||||||.|.|||:||.||.:.::..||:
  Fly   261 VRYMVAEKFVDLQKAVGPEITRVDLVPAFQYLLKDAEAEVRAAVATKVKDFCANLDKVNQVQIIL 325

Zfish   324 THILPCVKELVSDTNQHVKSALASVIMGLSTILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNL 388
            :.|||.|::||||.|.||||||||||||||.:||...|:|.||||||.|||||||||||||||||
  Fly   326 SSILPYVRDLVSDPNPHVKSALASVIMGLSPMLGAYQTVEQLLPLFLIQLKDECPEVRLNIISNL 390

Zfish   389 DCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVD 453
            ||||:||||:||||||||||||||||:|||||||||||||.||||||.||||:||..|||.||.|
  Fly   391 DCVNDVIGIQQLSQSLLPAIVELAEDSKWRVRLAIIEYMPALAGQLGQEFFDQKLRGLCMGWLND 455

Zfish   454 HVYAIREAATCNLMKLVEKFGAEWAQNTIVPKVLGMANDPNYLHRMTTLFCINALSEVCGQEITT 518
            ||||||||||.|:.||||:|||.||:..|:|.:|.|:.:.|||||||.|||:|.|:||||.:|||
  Fly   456 HVYAIREAATLNMKKLVEQFGAPWAEQAIIPMILVMSRNKNYLHRMTCLFCLNVLAEVCGTDITT 520

Zfish   519 KHMLPVVLKMSNDQVANVRFNVAKSLQKIGPVLDSSCLQTEVKPVLEKLASDQDMDVKYFAQEAI 583
            |.:||.||.::.|.||||||||||:||||.|.|::|.:..:|||.|:||.:|.|:|||:||.:||
  Fly   521 KLLLPTVLLLAADPVANVRFNVAKTLQKISPFLEASVIDAQVKPTLDKLNTDTDVDVKHFAAQAI 585

Zfish   584 S 584
            :
  Fly   586 A 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppp2r1ba	NP_001299846.1	HEAT_2	13..113	CDD:290374	87/99 (88%)
		HEAT repeat	13..37	CDD:293787	22/23 (96%)
		HEAT repeat	51..78	CDD:293787	23/26 (88%)
		HEAT repeat	88..118	CDD:293787	24/29 (83%)
		HEAT repeat	127..152	CDD:293787	18/24 (75%)
		HEAT repeat	163..192	CDD:293787	21/28 (75%)
		HEAT	166..196	CDD:281045	22/29 (76%)
		HEAT	174..>462	CDD:224331	222/287 (77%)
		HEAT repeat	204..234	CDD:293787	21/29 (72%)
		HEAT repeat	245..269	CDD:293787	18/23 (78%)
		HEAT	283..313	CDD:281045	23/29 (79%)
		HEAT repeat	283..311	CDD:293787	22/27 (81%)
		HEAT repeat	325..355	CDD:293787	23/29 (79%)
		HEAT repeat	364..390	CDD:293787	23/25 (92%)
		NADB_Rossmann	<396..>454	CDD:304358	48/57 (84%)
		HEAT repeat	401..430	CDD:293787	27/28 (96%)
		HEAT repeat	442..468	CDD:293787	19/25 (76%)
		HEAT repeat	479..508	CDD:293787	15/28 (54%)
		HEAT_2	489..584	CDD:290374	57/94 (61%)
		HEAT repeat	518..544	CDD:293787	17/25 (68%)
		HEAT repeat	559..585	CDD:293787	15/26 (58%)
Pp2A-29B	NP_001245944.1	HEAT_2	15..115	CDD:290374	87/99 (88%)
		HEAT repeat	15..39	CDD:293787	22/23 (96%)
		HEAT repeat	53..80	CDD:293787	23/26 (88%)
		HEAT repeat	90..120	CDD:293787	24/29 (83%)
		HEAT repeat	129..154	CDD:293787	18/24 (75%)
		HEAT repeat	165..194	CDD:293787	21/28 (75%)
		HEAT_2	175..267	CDD:290374	69/91 (76%)
		HEAT_EZ	181..230	CDD:290247	37/48 (77%)
		HEAT repeat	206..232	CDD:293787	17/25 (68%)
		HEAT repeat	247..271	CDD:293787	18/23 (78%)
		HEAT repeat	285..313	CDD:293787	22/27 (81%)
		HEAT repeat	327..357	CDD:293787	23/29 (79%)
		HEAT repeat	366..392	CDD:293787	23/25 (92%)
		HEAT repeat	403..432	CDD:293787	27/28 (96%)
		HEAT repeat	444..470	CDD:293787	19/25 (76%)
		HEAT repeat	481..510	CDD:293787	15/28 (54%)
		HEAT repeat	520..546	CDD:293787	17/25 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596607
Domainoid	1	1.000	265	1.000	Domainoid score	I1859
eggNOG	1	0.900	-	-		E1_KOG0211
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	854	1.000	Inparanoid score	I415
OMA	1	1.010	-	-		QHG54034
OrthoDB	1	1.010	-	-		D171719at33208
OrthoFinder	1	1.000	-	-		FOG0001701
OrthoInspector	1	1.000	-	-		otm25761
orthoMCL	1	0.900	-	-		OOG6_101100
Panther	1	1.100	-	-	LDO	PTHR10648
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1
SonicParanoid	1	1.000	-	-		X1096
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800