Protein Alignment Pcmt and PCMTD2

DIOPT Version :10

• Sequence 1: NP_536756.1
• Gene: Pcmt / 40668
• FlyBaseID: FBgn0086768
• Length: 226
• Species: Drosophila melanogaster
• Sequence 2: NP_060727.2
• Gene: PCMTD2 / 55251
• HGNCID: 15882
• Length: 361
• Species: Homo sapiens
• Alignment Length: 227
• Identity: 58/227 - (25%)
• Similarity: 106/227 - (46%)
• Gaps: 23/227 - (10%)

  Fly     5 SVGANNEDLIRQLKDHGVIASDAVAQAMKETDRKHY----SPRNPYMDAPQPIGGGVTISAPHMH 65
            |.|.:|::||..||:...|.::.|.||.:..||..|    ...|.|.|.... .|.:.:|||.::
Human     6 SAGEDNDELIDNLKEAQYIRTELVEQAFRAIDRADYYLEEFKENAYKDLAWK-HGNIHLSAPCIY 69

  Fly    66 AFALEYLRDHLKPGARILDVGSGSGYLTACFYRYIKAKGVDADTRIVGIEHQAELVRRSKANLN- 129
            :..:|.|  .|:||...|::|||:|||::.....:...||:.     |:|..::::..:|..|:
Human    70 SEVMEAL--DLQPGLSFLNLGSGTGYLSSMVGLILGPFGVNH-----GVELHSDVIEYAKQKLDF 127

  Fly   130 ----TDDRSMLDSGQLLIVEGDGRKGYPPNAPYNAIHVGAAAPDTPTELI-NQLASGGRLIVPVG 189
                :|.....|..:...|.|:..:..|..:.|:.::.||.......|.: |.|..||.|::|:
Human   128 FIRTSDSFDKFDFCEPSFVTGNCLEISPDCSQYDRVYCGAGVQKEHEEYMKNLLKVGGILVMPL- 191

  Fly   190 PDGGSQYMQQYDKDANGKVEMTRLMGVMYVPL 221
                .:.:.:..:......|..:::.|.:.||
Human   192 ----EEKLTKITRTGPSAWETKKILAVSFAPL 219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pcmt	NP_536756.1	PCMT	8..221	CDD:395902	54/222 (24%)
PCMTD2	NP_060727.2	PCMT	11..219	CDD:395902	54/220 (25%)
		AdoMet binding motif. /evidence=ECO:0000250|UniProtKB:Q96MG8	85..94		5/8 (63%)
		AdoMet binding motif. /evidence=ECO:0000250|UniProtKB:Q96MG8	160..164		1/3 (33%)
		AdoMet binding motif. /evidence=ECO:0000250|UniProtKB:Q96MG8	181..191		4/9 (44%)
		BC-box. /evidence=ECO:0000250|UniProtKB:Q96MG8	240..250
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..336
		CUL-box. /evidence=ECO:0000250|UniProtKB:Q96MG8	345..348