DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pcmt and PCMT1

DIOPT Version :9

Sequence 1:	NP_536756.1	Gene:	Pcmt / 40668	FlyBaseID:	FBgn0086768	Length:	226	Species:	Drosophila melanogaster
Sequence 2:	NP_001238978.1	Gene:	PCMT1 / 5110	HGNCID:	8728	Length:	286	Species:	Homo sapiens

Alignment Length:	223	Identity:	125/223 - (56%)
Similarity:	159/223 - (71%)	Gaps:	5/223 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAWRSVGANNEDLIRQLKDHGVIASDAVAQAMKETDRKHYSPRNPYMDAPQPIGGGVTISAPHMH 65
            |||:|.||::.:||..|:.:|:|.:|.|.:.|..|||.||:..|||||:||.||...||||||||
Human    59 MAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNPYMDSPQSIGFQATISAPHMH 123

  Fly    66 AFALEYLRDHLKPGARILDVGSGSGYLTACFYRYIKAKGVDADTRIVGIEHQAELVRRSKANLNT 130
            |:|||.|.|.|..||:.||||||||.|||||.|.:...|     :::||:|..|||..|..|:..
Human   124 AYALELLFDQLHEGAKALDVGSGSGILTACFARMVGCTG-----KVIGIDHIKELVDDSVNNVRK 183

  Fly   131 DDRSMLDSGQLLIVEGDGRKGYPPNAPYNAIHVGAAAPDTPTELINQLASGGRLIVPVGPDGGSQ 195
            ||.::|.||::.:|.||||.||...|||:|||||||||..|..||:||..|||||:||||.||:|
Human   184 DDPTLLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPAGGNQ 248

  Fly   196 YMQQYDKDANGKVEMTRLMGVMYVPLTD 223
            .::||||..:|.::|..||||:||||||
Human   249 MLEQYDKLQDGSIKMKPLMGVIYVPLTD 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pcmt	NP_536756.1	PCMT	8..221	CDD:250389	116/212 (55%)
Pcmt	NP_536756.1	AdoMet_MTases	13..223	CDD:302624	117/209 (56%)
PCMT1	NP_001238978.1	PCMT	66..274	CDD:250389	116/212 (55%)
PCMT1	NP_001238978.1	AdoMet_MTases	71..278	CDD:302624	119/211 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145654
Domainoid	1	1.000	235	1.000	Domainoid score	I2384
eggNOG	1	0.900	-	-		E1_COG2518
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55895
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3260
Isobase	1	0.950	-	0	Normalized mean entropy	S2607
OMA	1	1.010	-	-		QHG53644
OrthoDB	1	1.010	-	-		D1138104at2759
OrthoFinder	1	1.000	-	-		FOG0002960
OrthoInspector	1	1.000	-	-		oto88667
orthoMCL	1	0.900	-	-		OOG6_100731
Panther	1	1.100	-	-	O	PTHR11579
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R925
SonicParanoid	1	1.000	-	-		X2315
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	16	15.790