Protein Alignment mia and TAF6

DIOPT Version :10

• Sequence 1: NP_649547.3
• Gene: mia / 40667
• FlyBaseID: FBgn0014342
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: NP_011403.1
• Gene: TAF6 / 852766
• SGDID: S000003080
• Length: 516
• Species: Saccharomyces cerevisiae
• Alignment Length: 500
• Identity: 102/500 - (20%)
• Similarity: 198/500 - (39%)
• Gaps: 130/500 - (26%)

  Fly    32 SPRSLSAIFFHSTGL-HLDDGVAQWLSINVKEDITNLLNEAGKYMRRIRDRRLQLSHIQHAVRM- 94
            ||:........|.|| :::|.|.:.|:::|:..|..::.:|.|:.|..:...|....:..|:|:
Yeast    12 SPQDTVKDVAESLGLENINDDVLKALAMDVEYRILEIIEQAVKFKRHSKRDVLTTDDVSKALRVL 76

  Fly    95 -----------------------------------HDDLCYDIFFRLVHCDDCKMPPSQKVLKT- 123
                                               .:::.:|   ||:: :.....|......|
Yeast    77 NVEPLYGYYDGSEVNKAVSFSKVNTSGGQSVYYLDEEEVDFD---RLIN-EPLPQVPRLPTFTTH 137

  Fly   124 ------VREAVTAEKK-DELLVSYPESVQESVPEPVPETSLEPP---------------PMHTGW 166
                  |:.|:..... :::.||.|..::.::...:.:.||:.|               ..|...
Yeast   138 WLAVEGVQPAIIQNPNLNDIRVSQPPFIRGAIVTALNDNSLQTPVTSTTASASVTDTGASQHLSN 202

  Fly   167 LKVEQ-VLLKPSKRYPLSMEQQNFFELVTEACVGDLES------RRVLALKAISTDPSLEELLPR 224
            :|..| ..:||..::.||.|.|.:|..|........::      .:..||.::.||..|.:|:|.
Yeast   203 VKPGQNTEVKPLVKHVLSKELQIYFNKVISTLTAKSQADEAAQHMKQAALTSLRTDSGLHQLVPY 267

  Fly   225 LTKFIADAVAINVAQQNLPLLLYLMRMVRALLGNQRFSLLQYLHLLLPAVLSCLLAKQVCASPNS 289
            ..:|||:.:..|::  :|.||..::.|:.:||.|....|..|:|.|:|::|:.||||::..||..
Yeast   268 FIQFIAEQITQNLS--DLQLLTTILEMIYSLLSNTSIFLDPYIHSLMPSILTLLLAKKLGGSPKD 330

  Fly   290 EDHW----------ALREYSGNIMAHIVRQFDAADNGILPRVIGVYNKALLKK--PLTTVFGAVI 342
            :...          |||:::.:::.:::::|..|...:.|||    .:.|||.  .:..|||...
Yeast   331 DSPQEIHEFLERTNALRDFAASLLDYVLKKFPQAYKSLKPRV----TRTLLKTFLDINRVFGTYY 391

  Fly   343 G----------------LGKMGNHAVRACILPQLKYLSEHIDSHMAASNDSPSSSVDRQAVKYIR 391
            |                ||.:.|.|  ..:..:.....::|:.|:   ||..:.:    ..|:.:
Yeast   392 GCLKGVSVLEGESIRFFLGNLNNWA--RLVFNESGITLDNIEEHL---NDDSNPT----RTKFTK 447

  Fly   392 HRLMKMCSPVLMGI----HQPPDL------------PEEFMERYG 420
            .....:...|:..:    ...|||            .|:.:||.|
Yeast   448 EETQILVDTVISALLVLKKDLPDLYEGKGEKVTDEDKEKLLERCG 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mia	NP_649547.3	HFD_SF	<47..94	CDD:480273	10/46 (22%)
		TAF6C	181..397	CDD:381749	60/249 (24%)
		HEAT repeat	184..215	CDD:381749	6/36 (17%)
		HEAT repeat	222..257	CDD:381749	10/34 (29%)
		HEAT repeat	267..310	CDD:381749	13/52 (25%)
		HEAT repeat	317..347	CDD:381749	12/47 (26%)
		HEAT repeat	349..396	CDD:381749	7/46 (15%)
TAF6	NP_011403.1	TAF6	6..513	CDD:227426	101/499 (20%)