DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mia and taf6

DIOPT Version :9

Sequence 1:	NP_001138010.1	Gene:	mia / 40667	FlyBaseID:	FBgn0014342	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_001004557.1	Gene:	taf6 / 447818	ZFINID:	ZDB-GENE-040912-23	Length:	636	Species:	Danio rerio

Alignment Length:	604	Identity:	167/604 - (27%)
Similarity:	276/604 - (45%)	Gaps:	102/604 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RRHSLS----PRSLSAIFFHSTGL-HLDDGVAQWLSINVKEDITNLLNEAGKYMRRIRDRRLQLS 86
            ||..|.    |.........|.|: .|.:.....||..|...|..:..:|.|:|...:..:|...
Zfish     5 RRQKLCSVILPTDSMKAMAESVGIGSLQEDSCLTLSEEVSYRIKEIAQDALKFMHHGKRCKLTTG 69

  Fly    87 HIQHAVRMHD-DLCYD------IFFRL-------VHCDDCKMPPSQKVLKTVREAVTAE---KKD 134
            .|.||:::.: :..|.      |.||.       :|..:.|......::.|....|..:   |..
Zfish    70 DIDHALKLKNVEPLYGFQSEEFIPFRFASGGGRELHFYEEKEVDLSDIINTPLPRVPLDVSLKAH 134

  Fly   135 ELLVSYPESVQESVPEPVPETSLE--------------PPPMHTGWLKV-------------EQV 172
            .|.:   :.||.::||..|..|.|              |.....|:::.             |::
Zfish   135 WLSI---DGVQPAIPENPPSASKEQQKAESTEPLKAVKPGQEDEGFIQAKGQSAVSAEVKGKEKM 196

  Fly   173 LLKPSKRYPLSMEQQNFFELVTEACVGDLESRRVLALKAISTDPSLEELLPRLTKFIADAVAINV 237
            .:||...:.||:|||.:::.:||||||..|::|..||::|:|||.|.::|||.:.||::.|.:||
Zfish   197 RMKPRSTHELSVEQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNV 261

  Fly   238 AQQNLPLLLYLMRMVRALLGNQRFSLLQYLHLLLPAVLSCLLAKQVCASPNSEDHWALREYSGNI 302
            .|.||.||:||||||:||:.|....|.:|||.|:|||::|:::||:|..|:.::|||||:::..:
Zfish   262 VQNNLALLIYLMRMVKALMDNPTLYLEKYLHELIPAVVTCIVSKQLCLRPDVDNHWALRDFAARL 326

  Fly   303 MAHIVRQFDAADNGILPRVIGVYNKALL--KKPLTTVFGAVIGLGKMGNHAVRACILPQLKYLSE 365
            ||...:.|....|.|..|:...:.||||  |...||.:|.:.||.::|:..::..|:|:|.....
Zfish   327 MAQSCKTFSTTTNNIQSRITKTFTKALLDEKTQWTTRYGCIAGLAELGHDVIKTLIIPRLFVEGA 391

  Fly   366 HIDSHMAASNDSP-SSSVDRQAVKYIRHRLMKMCSPVLMGIHQPPDLPEEFMERYGSLGTLMSDG 429
            .|.:.|    |.| .|::|:....:::..|:|.|:.|:......|||.|::...||.|||::...
Zfish   392 RIKAVM----DGPVVSNIDKIGADHVQSLLLKHCASVVAKTRPVPDLVEQYKADYGYLGTMLCSH 452

  Fly   430 VTVMRTKKQAVAAAKAEAELKLKNMATEHLNSRGKGSRSVGSNDLVSGTQLPKNGIRPT---SQA 491
            |    .|.:|.||.:|:.                           |:.|.|.....|||   ||:
Zfish   453 V----VKARAQAAFQAQT---------------------------VNRTTLTITQPRPTLTMSQS 486

  Fly   492 PKSVYSISVNGQTVKISTPNLCNTMLQHQKKDLFSKPSDFVVPQLVVNQFKNG-----LIPSNSQ 551
            ..|...:|.....:|:.:    :..|...:....::||......:|:......     :|..:|.
Zfish   487 GLSTSGVSRTPSIIKVPS----SLTLMSTRPGTPTQPSPPATKYIVMATSAGAASTQQVITLSSS 547

  Fly   552 RSSSPARNVIHLKPNNDHP 570
            :|.||..:.:...|.:..|
Zfish   548 QSGSPVTSTVPSTPTSLQP 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mia	NP_001138010.1	TAF6	33..352	CDD:173968	114/365 (31%)
mia	NP_001138010.1	TAF6	40..422	CDD:227426	132/429 (31%)
taf6	NP_001004557.1	TAF6	15..378	CDD:173968	114/365 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D384329at2759
OrthoFinder	1	1.000	-	-		FOG0003125
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020