DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mia and Taf6l

DIOPT Version :9

Sequence 1:	NP_001138010.1	Gene:	mia / 40667	FlyBaseID:	FBgn0014342	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_001101045.1	Gene:	Taf6l / 309194	RGDID:	1310123	Length:	623	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	135/577 - (23%)
Similarity:	221/577 - (38%)	Gaps:	169/577 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 MKTSQNEMPDKDKSFRRHSLSPRSLSAIFFHSTGLHLDDGVAQWLSINVKEDITNLLNEA----G 72
            |.:|...|.::::  ||....||....:...||||.|.|.||..|:    ||:...|.||    .
  Rat     1 MHSSTGAMSEREE--RRFVEIPRESVRLMAESTGLELSDEVAALLA----EDVCYRLREATQNSS 59

  Fly    73 KYMRRIRDRRLQLSHIQHAVRMH--DDLC-YDIFFRLVHCDDCKMPPSQKVLKTVREAVTAEKKD 134
            ::|:..:.|:|.:.....|:|..  :.:| |.               ||:|| .:|.|    ::.
  Rat    60 QFMKHTKRRKLTVEDFNRALRWSSVEAVCGYG---------------SQEVL-PLRPA----REG 104

  Fly   135 ELLVSYPE---------SVQESVPEPVPETSLEPPPMHTGWLKVEQVLLK----PSKRYPLSMEQ 186
            ||.  :||         ::..::|:...||::.   :|..:|..:..|..    ||....|:.:.
  Rat   105 ELY--FPEDREVNLVELALATNIPKGCAETAVR---VHVSYLDGKGNLAPQGSVPSAVSSLTDDL 164

  Fly   187 QNFFELVTEACVGDLESRRVLALKAISTDPSLEELLPRLTKFIADAVAINVAQQNLPLLLYLMRM 251
            ..:::.||.|.:||......:||:.:.|:..:..|||   .|:.....:.....:|..|..|:::
  Rat   165 LKYYQQVTRAVLGDDPQLMKVALQDLQTNSKIAALLP---YFVYVVSGVKSVSHDLEQLHRLLQV 226

  Fly   252 VRALLGNQRFSLLQYLHLLLPAVLSCLLAKQVCASPNS-EDHWALREYSGNIMAHIVRQFDAADN 315
            .|:|:.|....|..|:..|:.:||.|:| :.:.||.|. .|||.||:.:..:::||.     ..:
  Rat   227 ARSLIRNPHLCLGPYVRSLVGSVLYCVL-EPLAASINPLNDHWTLRDGAALLLSHIF-----WTH 285

  Fly   316 GILPRVIGVYNKALLK---------KPLTTVFGAVIGLGKMGNHAVRACILPQLKYLSEHIDSHM 371
            |.|  |.|:|.:.||.         :||.:.:|||:||..:|..||...:.|   :|..:..:..
  Rat   286 GDL--VSGLYQQILLSLQKVLTDPVRPLCSHYGAVVGLHALGWKAVERVLYP---HLPTYWTNLQ 345

  Fly   372 AASNDSPSSSVDRQAVKYIRHRLMKMCSPVLMGIHQPPDLPEEFMERYGSLGTLMSDGVTVMRTK 436
            |..:|   .||....||...|::                        ||::
  Rat   346 AVLDD---YSVSNAQVKADGHKV------------------------YGAI-------------- 369

  Fly   437 KQAVAAAKAEAELKLKNMATEHLNSRGKGSRSVGSNDLVSGTQLPKNGIRPTSQAPKSVYSISVN 501
                 ....|..||:|..|.|. |..|.|.|                |.||....|..
  Rat   370 -----LVAVERLLKMKAQAAEP-NRGGLGGR----------------GYRPAEDLPWD------- 405

  Fly   502 GQTVKISTPNLCNTMLQHQKKDLFSKPSDFVVPQLVVNQFKNG-LIPSNSQRSSSPA 557
                        :.:||.......|:|.           |.:| |:||....|..|:
  Rat   406 ------------SLLLQESPPGGGSEPG-----------FGSGLLLPSGVAGSEDPS 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mia	NP_001138010.1	TAF6	33..352	CDD:173968	92/348 (26%)
mia	NP_001138010.1	TAF6	40..422	CDD:227426	103/411 (25%)
Taf6l	NP_001101045.1	TAF	16..80	CDD:281032	20/67 (30%)
		TAF6C	160..372	CDD:381749	64/271 (24%)
		HEAT repeat	162..193	CDD:381749	7/30 (23%)
		HEAT repeat	200..232	CDD:381749	8/34 (24%)
		HEAT repeat	242..285	CDD:381749	15/48 (31%)
		HEAT repeat	292..324	CDD:381749	10/31 (32%)
		HEAT repeat	326..371	CDD:381749	13/93 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350488
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5095
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D384329at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750