Protein Alignment mia and TAF6L

DIOPT Version :9

• Sequence 1: NP_001138010.1
• Gene: mia / 40667
• FlyBaseID: FBgn0014342
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: NP_006464.1
• Gene: TAF6L / 10629
• HGNCID: 17305
• Length: 622
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 124/507 - (24%)
• Similarity: 202/507 - (39%)
• Gaps: 123/507 - (24%)

  Fly    23 DKSFRRHSLSPRSLSAIFFHSTGLHLDDGVAQWLSINVKEDITNLLNEA----GKYMRRIRDRRL 83
            ::..||....||....:...||||.|.|.||..|:    ||:...|.||    .::|:..:.|:|
Human     3 EREERRFVEIPRESVRLMAESTGLELSDEVAALLA----EDVCYRLREATQNSSQFMKHTKRRKL 63

  Fly    84 QLSHIQHAVRMH--DDLC-YDIFFRLVHCDDCKMPPSQKVLKTVREAVTAEKKDELLVSYPE--- 142
            .:.....|:|..  :.:| |.               ||:.| .:|.|    ::.||.  :||
Human    64 TVEDFNRALRWSSVEAVCGYG---------------SQEAL-PMRPA----REGELY--FPEDRE 106

  Fly   143 ------SVQESVPEPVPETSLEPPPMHTGWLKVEQVLLK----PSKRYPLSMEQQNFFELVTEAC 197
                  ::..::|:...||::.   :|..:|..:..|..    ||....|:.:...::..||.|.
Human   107 VNLVELALATNIPKGCAETAVR---VHVSYLDGKGNLAPQGSVPSAVSSLTDDLLKYYHQVTRAV 168

  Fly   198 VGDLESRRVLALKAISTDPSLEELLPRLTKFIADAVAINVAQQNLPLLLYLMRMVRALLGNQRFS 262
            :||......:||:.:.|:..:..|||   .|:.....:.....:|..|..|:::.|:|..|....
Human   169 LGDDPQLMKVALQDLQTNSKIGALLP---YFVYVVSGVKSVSHDLEQLHRLLQVARSLFRNPHLC 230

  Fly   263 LLQYLHLLLPAVLSCLLAKQVCASPNS-EDHWALREYSGNIMAHIVRQFDAADNGILPRVIGVYN 326
            |..|:..|:.:||.|:| :.:.||.|. .|||.||:.:..:::||.     ..:|.|  |.|:|.
Human   231 LGPYVRCLVGSVLYCVL-EPLAASINPLNDHWTLRDGAALLLSHIF-----WTHGDL--VSGLYQ 287

  Fly   327 KALLK---------KPLTTVFGAVIGLGKMGNHAVRACILPQLKYLSEHIDSHMAASNDSPSSSV 382
            ..||.         :||...:|||:||..:|..||...:.|   :||.:..:..|..:|   .||
Human   288 HILLSLQKILADPVRPLCCHYGAVVGLHALGWKAVERVLYP---HLSTYWTNLQAVLDD---YSV 346

  Fly   383 DRQAVKYIRHRLMKMCSPVLMGIHQPPDLPEEFMERYGSLGTLMSDGVTVMRTKKQAVAAAKAEA 447
            ....||...|::                        ||::      .|.|.|..|....||:...
Human   347 SNAQVKADGHKV------------------------YGAI------LVAVERLLKMKAQAAEPNR 381

  Fly   448 ------------ELKLKNMATEHLNSRGKGSRSVGSNDLVSGTQLPKNGIRP 487
                        :|...::..:..:|.|....|.|     ||..||..|..|
Human   382 GGPGGRGCRRLDDLPWDSLLFQESSSGGGAEPSFG-----SGLPLPPGGAGP 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mia	NP_001138010.1	TAF6	33..352	CDD:173968	91/348 (26%)
		TAF6	40..422	CDD:227426	103/411 (25%)
TAF6L	NP_006464.1	TAF	9..73	CDD:281032	20/67 (30%)
		TAF6C	153..365	CDD:381749	65/258 (25%)
		HEAT repeat	155..186	CDD:381749	7/30 (23%)
		HEAT repeat	193..225	CDD:381749	8/34 (24%)
		HEAT repeat	235..278	CDD:381749	15/48 (31%)
		HEAT repeat	285..317	CDD:381749	10/31 (32%)
		HEAT repeat	319..364	CDD:381749	14/80 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	403..430		10/31 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	457..546

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156573
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5095
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D384329at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750