DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and GLR1.3

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_199652.1	Gene:	GLR1.3 / 834896	AraportID:	AT5G48410	Length:	860	Species:	Arabidopsis thaliana

Alignment Length:	885	Identity:	181/885 - (20%)
Similarity:	326/885 - (36%)	Gaps:	243/885 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 PIKTVFNVCDKLIENRVYAVV----VSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKN 145
            |:..:.:..|.|....|.|::    :...:..|:|...|        .:|:|   |.|:.||
plant    91 PLLALASAVDLLKTEGVEAIIGGNSLLEAKLLGELGEKA--------RVPMI---SLDSPFS--- 141

  Fly   146 IHVSFLRTVPPYYHQADVWLEMLSHFAYTKVI-IIHSSDTDGRAILG-----RFQTTSQTYYDDV 204
                                  ||...||.:| ..|.|.::.:.|..     .:.:.:..|.|..
plant   142 ----------------------LSLSKYTHLIQATHDSTSEAKGITSFINVFDWNSVALVYEDHD 184

  Fly   205 DVRATVELIVE--------FEPKL-------ESFT-EHLIDMKTAQSRVYLMYASTEDAQVIFRD 253
            |.|.:::|:||        .:.|:       |.|. ..|..:|...:.|::::.|...|..:|..
plant   185 DWRESMQLLVEHFHENGVRVQSKVGFTVSSSEDFVMGRLQQLKDLGTTVFVVHLSEVIATHLFPC 249

  Fly   254 AGEYNMTGEGHVWIVTEQAL---------FSNNTPDGVLG---------------------LQLE 288
            |....:.|:|.|||:|.:.:         |:....:||:|                     |.:|
plant   250 ARRLGLMGDGFVWILTAKTMNSFHENIDDFTKQAMEGVVGFKSYIPMSIELQNFTLRWRKSLPVE 314

  Fly   289 HAHSDKGHI-----RDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESGKRLFQYLKSRNITG 348
            .|...:..|     .|..:.||.| .|:|....:...                |.:.:......|
plant   315 EAELTRLSISGIWAHDIAFALARA-AEVIRMPNVTST----------------LLEEITKTRFNG 362

  Fly   349 ETGQVAFDDNGDRIYAG-YDVINIREQQKKHV-----VGKFSYDSMRAKMRMRINDSE-IIWPGK 406
            .:|.  |..|..::.:. :::||:....::.|     .|.|   |.|..:....|..| |||||.
plant   363 LSGD--FQLNDKKLLSNKFEIINMIGSSERRVGFLNSNGSF---SNRRHLSSTHNKLETIIWPGG 422

  Fly   407 QRRKPEGIMI----PTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRG 467
            ..:.|:|..:    ...||:|......|..:.::                  .:|...||....|
plant   423 SAQSPKGTSLIDSDRKKLRVLVTSSNRFPRLMKV------------------ETDPVTNELIVEG 469

  Fly   468 YCIDLL-IELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPL 531
            :||::. ..:|.   |.|::...|.....:|    :..|..|..:         .::.|..|..:
plant   470 FCIEVFRASISP---FNYEVEYIPWLNGSNY----DNLAYALHSQ---------KDKYDAAVGDI 518

  Fly   532 TINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDR 596
            ||...|:.|::|:.||...|:.|:..| .||..:  |.||.:..|||.......:..::::|::|
plant   519 TITSNRSTYVDFTLPFTEMGLGIVAVK-ERSMWV--FFQPLTPDLWITSAFFFVLTGVIVWLIER 580

  Fly   597 FSPFGRFKLSHSDSNEEKA---LNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMII 658
                       :::.|.:.   ..:...:||.:..|:.:. .|....:.| |.:..||....:|:
plant   581 -----------AENKEFQGSWPQQIGVVLWFGFSTLVYAH-REKLKHNLS-RFVVTVWVFAVLIL 632

  Fly   659 VASYTANLAAFLVLERPKTK--------LSGINDARLRNTMENLTCATVKGSSVDMYFRRQVELS 715
            .|||||.|.:.:.:::.:..        |||...|.:..|..:|
plant   633 TASYTATLTSMMTVQQIRFNSNEDYVGHLSGSLIANVALTSSSL--------------------- 676

  Fly   716 NMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGE----LF------GR 770
            ...|::..|:.|...||:.:    |.::|:.|  .|.|..      |..||    .|      ..
plant   677 RAMRSLGLNSAADYAQALLN----KTVSFVVD--ELPYLK------VVLGENPTHFFMVKTQSTT 729

  Fly   771 SGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPNTLGLKNMAGV 835
            :|:|...|||......|:..|.:...|..:.:::|:| |...:....   :.|.|.:.|....|:
plant   730 NGFGFMFQKGFELVPNVSREISKLRTSEKLNEMEKRW-FDNQLPYTT---DDTSNPITLYRFRGL 790

  Fly   836 FILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIA---RH 872
            ||::||..|..:.:::|..:..|.::... .||::   ||
plant   791 FIIIGVSFAFALAVLVILCLRDKWEILVD-NLDLSQRLRH 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	76/387 (20%)
		ANF_receptor	58..371	CDD:279440	65/347 (19%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	86/422 (20%)
		HisJ	451..>558	CDD:223904	24/107 (22%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	29/137 (21%)
		Lig_chan	575..838	CDD:278489	57/283 (20%)
		CaM_bdg_C0	854..882	CDD:287524	5/22 (23%)
GLR1.3	NP_199652.1	PBP1_GABAb_receptor	43..405	CDD:107361	70/371 (19%)
		ANF_receptor	57..385	CDD:279440	66/348 (19%)
		GluR_Plant	438..767	CDD:270404	85/412 (21%)
		Lig_chan	559..798	CDD:278489	60/288 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010