DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and GLR2.5

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001332219.1	Gene:	GLR2.5 / 830991	AraportID:	AT5G11210	Length:	918	Species:	Arabidopsis thaliana

Alignment Length:	944	Identity:	192/944 - (20%)
Similarity:	356/944 - (37%)	Gaps:	202/944 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 VTYYDKTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGI-S 135
            ||..|.::|.....:...:|..:. .:.|:...|...:||....:.:|:........:.:||. :
plant    47 VTLADLSLRAINMSLSEFYNTHNG-FKTRIVLNVRDSKQTVVGAAASALYLIKKREVVAIIGPGT 110

  Fly   136 SRDAAF------SDKNIHVSFLRTVP-------PYY--------HQADVWLEMLSHFAYTKVIII 179
            |..|.|      ..|...:||..|.|       ||:        .|......::..|.:.:|:.|
plant   111 SMQAPFLINLGNQSKVPIISFSATSPLLDSLRSPYFIRATHDDSSQVQAISAIIESFRWREVVPI 175

  Fly   180 HSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYAST 244
            :..:..|..||......    :.:::||......:......:...:.|..:.|..:||::::...
plant   176 YVDNEFGEGILPNLVDA----FQEINVRIRYRSAISLHYSDDQIKKELYKLMTMPTRVFIVHMLP 236

  Fly   245 EDAQVIFRDAGEYNMTGEGHVWIVT-----------EQALFSNNTPDGVLGLQLEHAHS-DKGHI 297
            :....:|..|.|.:|..:|:|||||           |.:|.:.:   ||||::...|.| :..|:
plant   237 DLGSRLFSIAKEIDMLSKGYVWIVTNGIADLMSIMGESSLVNMH---GVLGVKTYFAKSKELLHL 298

  Fly   298 R--------------------DSVYVLASAIKE-----MISNETIAEAPKDCGDSAVNWE----- 332
            .                    |:...||.:::|     |..|.|..:..:|  |...:.:
plant   299 EARWQKRFGGEELNNFACWAYDAATALAMSVEEIRHVNMSFNTTKEDTSRD--DIGTDLDELGVA 361

  Fly   333 -SGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHV--------------VGK 382
             ||.:|...|.:.:..|..|:... .||......:.:|||.|..::.|              |.|
plant   362 LSGPKLLDALSTVSFKGVAGRFQL-KNGKLEATTFKIINIEESGERTVGFWKSKVGLVKSLRVDK 425

  Fly   383 FSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDE 447
            .|:.|.|.:        .|||||.....|:|...||:.:.|.|     ...::.|
plant   426 VSHSSRRLR--------PIIWPGDTIFVPKGWEFPTNAKKLRI-----AVPKKDG---------- 467

  Fly   448 RPCPLFNN-----SDATANEFCCRGYCID----LLIELSKRINFTYDLALSPDGQFGHYILRNNT 503
                 |||     .|...|.....|:|||    ::.::...:::.|....:|||:     .|.:.
plant   468 -----FNNFVEVTKDENTNVPTVTGFCIDVFNTVMSQMPYAVSYEYIPFDTPDGK-----PRGSY 522

  Fly   504 GAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITIL-EKKPSRSSTLVS 567
            ..|.    :...:||.     |..|...||...|:.|::|:.|:...||..| ..|..:......
plant   523 DEMV----YNVFLGEF-----DGAVGDTTILANRSHYVDFALPYSETGIVFLVPVKDGKEKGEWV 578

  Fly   568 FLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKAL--NLSSAVWFAWGVLL 630
            ||:|.:..||::...|...:.:::::         |:....:...|:.:  .:||..:|::..|.
plant   579 FLKPLTKELWLVTAASFLYIGIMVWI---------FEYQADEEFREQMIIDKISSVFYFSFSTLF 634

  Fly   631 NSGIGEGTP-RSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENL 694
               .....| .||..|||.:||....:|:..||||.|.:.|.::..:..:..::|  ||.:..|:
plant   635 ---FAHRRPSESFFTRVLVVVWCFVLLILTQSYTATLTSMLTVQELRPTVRHMDD--LRKSGVNI 694

  Fly   695 TCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQA----IQDVKKGKLMAFIWDSSRLEYEA 755
            ...|  ||   ..|.|..::  .:.......|.:.|:.    :.....|.:.|...:.:.::...
plant   695 GYQT--GS---FTFERLKQM--RFDESRLKTYNSPEEMRELFLHKSSNGGIDAAFDEVAYIKLFM 752

  Fly   756 SKDC-ELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNC-- 817
            :|.| |.......|...|:|.....|||....::..||...|...|:.::.:| |.|  :::|
plant   753 AKYCSEYSIIEPTFKADGFGFAFPLGSPLVSDISRQILNITEGDAMKAIENKW-FLG--EKHCLD 814

  Fly   818 ELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVI-----YKKHQVKKQKRL---------- 867
            .....:|..|...:...:|::|.|     |.:|::.::     |::.|......|
plant   815 STTSDSPIQLDHHSFEALFLIVFV-----VSVILLLLMLASRGYQERQHNASPNLPNDQANAAQE 874

  Fly   868 ------DIARHAADKWRGTIEKRKTIRASLAMQR 895
                  ::..|..:.....:.::|....::.::|
plant   875 EVNEEGNVGDHIVEVDTALVRRKKLTSNTIPIRR 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	84/411 (20%)
		ANF_receptor	58..371	CDD:279440	72/363 (20%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	91/420 (22%)
		HisJ	451..>558	CDD:223904	28/116 (24%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	32/138 (23%)
		Lig_chan	575..838	CDD:278489	57/272 (21%)
		CaM_bdg_C0	854..882	CDD:287524	4/48 (8%)
GLR2.5	NP_001332219.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010