DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and GLR2.6

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001330285.1	Gene:	GLR2.6 / 830988	AraportID:	AT5G11180	Length:	967	Species:	Arabidopsis thaliana

Alignment Length:	1016	Identity:	209/1016 - (20%)
Similarity:	378/1016 - (37%)	Gaps:	251/1016 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 NPIKT--VFNVCDK-------------LIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYS-IPVI 132
            |..||  |.|:.|.             ||:.|....::.    .|:...|......|..| :|:|
plant    68 NGFKTRIVLNIRDSKRTVVGAAASALYLIKKREVVAIIG----PGNSMQAPFLINLGNQSQVPII 128

  Fly   133 GISSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAIL----GRF 193
            ..|:..... |......|:|.......|......::..|.:.:|:.|::.:..|..||    ..|
plant   129 SFSASSPVL-DSLRSPYFIRATHDDSSQVHAISAIIESFRWREVVPIYADNEFGEGILPYLVDAF 192

  Fly   194 QTTSQ--TYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGE 256
            |..:.  .|...:.|.:|.:|:          .:.|..:.|..:||::::...:....:|..|.|
plant   193 QEINVRIRYRSAISVHSTDDLV----------KKELYKLMTMPTRVFIVHMLPDLGSRLFSIAKE 247

  Fly   257 YNMTGEGHVWIVT-----EQALFSNNTPD---GVLGLQLEHAHSDK------------------- 294
            ..|..:|:|||||     :.::...::.:   ||||::...:.|.:
plant   248 IGMMTKGYVWIVTNGIADQMSVMGESSLENMHGVLGVKTYFSRSKELMYLETRWRKRFGGEELNN 312

  Fly   295 ----GHIRDSVYVLASAIKEMISN------ETIAEAPKDCGDSAVNWE------SGKRLFQYLKS 343
                |:  |:...||.:|:|:.||      :|.....:|  |:..:.:      ||.:|.|.|.:
plant   313 FECWGY--DTATALAMSIEEISSNVNMSFSQTKRNTSRD--DTGTDLDDLSFALSGPKLLQALAT 373

  Fly   344 RNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHV------VG------------KFSYDSMRA 390
            .:..|..|:... .||......:.::||.|..::.|      ||            |.|:.|.|.
plant   374 VSFKGVAGRFQL-KNGKLEATTFKIVNIEESGERTVGFWKSKVGLVKSLRVNQTGIKISHSSHRL 437

  Fly   391 KMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNN 455
            :        .|||||.....|:|...||:.:.|.|     ...::.|               |||
plant   438 R--------PIIWPGDTIFVPKGWEFPTNAKKLRI-----AVPKKDG---------------FNN 474

  Fly   456 -----SDATANEFCCRGYCIDL----LIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKE 511
                 .||..|.....|:|||:    :.::...:.:.|....:|||:     .|.:...|.
plant   475 FVEVTKDANTNAPTITGFCIDVFDTAMRQMPYAVPYEYIPFETPDGK-----PRGSYDEMV---- 530

  Fly   512 WTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGI-TILEKKPSRSSTLVSFLQPFSNT 575
            :...:||.     |..|...||...|:.|::|:.|:...|| .::..|..|......||:|.:..
plant   531 YHVFLGEF-----DGAVGDTTILANRSTYVDFALPYSETGIVVVVPVKDEREKGKWVFLKPLTRE 590

  Fly   576 LWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALN-LSSAVWFAWGVLLNSGIGEGTP 639
            ||.|...|...:.:::::.: :...|.|:       ::..:| :|:..:|::..|..:.:...
plant   591 LWFLTAASFLYIGIMVWIFE-YQASGDFR-------KQSIINKISNVFYFSFSTLFFAHMRPS-- 645

  Fly   640 RSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSV 704
            .|...|||.:||....:|:..||||.|.:.|.::..:..:..::|  |||:..|:...|  ||
plant   646 ESIFTRVLVVVWCFVLLILTQSYTATLTSMLTVQELRPTVRHMDD--LRNSGVNIGYQT--GS-- 704

  Fly   705 DMYFRRQVELSNMYRTMEANNYATAEQA----IQDVKKGKLMAFIWDSSRLEYEASKDCELVTAG 765
             ..|.|..::.  |:......|.|.::.    ::....|.:.|...:.:.::...:|.|...|..
plant   705 -FTFERLKQMG--YKESRLKTYDTPQEMHELFLKKSSNGGIDAAFDEVAYVKLFMAKYCSKYTII 766

  Fly   766 E-LFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNC--ELFEKTPNTL 827
            | .|...|:|.....|||....::..||...|...|:.::.:|:..   :::|  .....:|..|
plant   767 EPTFKADGFGFAFPLGSPLVPDLSRQILNITEGETMKAIENKWLLG---EKHCLDSTTSDSPIRL 828

  Fly   828 GLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKRKTIRASLA 892
            ...:...:|.:|.|     |.::::                :|.....::|
plant   829 DHHSFEALFTIVFV-----VSMLLL----------------LAMLVCRRYR-------------- 858

  Fly   893 MQRQYNVGLNSTHAPGTISLAVDKRRYPRLGQRLGPERAWPGDAADVLRIRRPYELGNPGQSPKV 957
             |...:..:|:.::|..                 |..||.|....|. .:|.|       .||.:
plant   859 -QESKSGEINANNSPTD-----------------GNMRAPPNQPTDD-NMRAP-------TSPPI 897

  Fly   958 --MAANQPGMPMPMLGKTRPQQSVLPPRYSPGYTSDVSHLV 996
              .....||   |.|.:...|..:|....:.|..::|..:|
plant   898 DDQVLEPPG---PALNEADDQDQLLNDEVNVGDRNEVDIIV 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	84/403 (21%)
		ANF_receptor	58..371	CDD:279440	71/351 (20%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	92/418 (22%)
		HisJ	451..>558	CDD:223904	28/116 (24%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	31/136 (23%)
		Lig_chan	575..838	CDD:278489	57/270 (21%)
		CaM_bdg_C0	854..882	CDD:287524	2/27 (7%)
GLR2.6	NP_001330285.1	PBP1_GABAb_receptor_plant	38..421	CDD:380645	77/372 (21%)
		GluR_Plant	460..810	CDD:270404	88/402 (22%)
		Lig_chan	590..842	CDD:365843	58/273 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010