DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and GLR1.4

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_187408.2	Gene:	GLR1.4 / 819940	AraportID:	AT3G07520	Length:	861	Species:	Arabidopsis thaliana

Alignment Length:	832	Identity:	167/832 - (20%)
Similarity:	318/832 - (38%)	Gaps:	219/832 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 VVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLS 169
            |:|..|....||.|..:|   |..      ::.|.:...|.|...|                  |
plant   137 VISSFQVPSSLSLAKYNY---FIQ------ATHDTSSEAKGIAALF------------------S 174

  Fly   170 HFAYTKVIIIHSSDTDGR----AILGRFQTTS--QTYYDDVDVRATVELIVEFEPKLESFTEHLI 228
            :|.:...::|:..|.|.|    .::|.||..:  ..|..:..|.:..|.|::   :|..|
plant   175 NFDWRTAVLIYEDDDDWRESIQPLVGHFQQNAIHIEYKAEFSVSSNEECIMK---QLRKF----- 231

  Fly   229 DMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFSNNTPD----------GVL 283
              |.:..|:::.:.|...|..:|..|....|..||:.||:|.:::  ||..|          ||:
plant   232 --KASGIRIFVAHISERIANRLFPCARRLGMMEEGYAWILTARSM--NNFQDTNYLAKEEMEGVI 292

  Fly   284 GLQ-----LEHAHSD----KGHIR----------------DSVYVLASAIKEMISNETIAEAPKD 323
            |.:     .|..|:.    |..:|                |..:.||.|.:       :|:.|
plant   293 GFKSYIPLTEELHNFTLRWKRSLRLEEVVTRMSVCSIWAHDIAWSLARAAE-------VAKLP-- 348

  Fly   324 CGDSAVNWESGKRLFQYL----KSRNITGETGQVAFDDN---GDRIYAGYDVINIREQQKKHVVG 381
                      |..::..|    :|....|.:|.:.|.|.   .|:    ::::|:..:.::. ||
plant   349 ----------GLSVYDLLEAIPESAKHKGLSGDIKFIDKKFISDK----FEIVNMIGRGERS-VG 398

  Fly   382 KFSYDSMRAKMRMRINDSE----IIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFR 442
            .::..|..:..|.|::.::    |||||...|.|         ::.:::||     |.....:.|
plant   399 LWNSGSFISNRRRRLSSTKALETIIWPGGSTRIP---------KIRSLKEK-----RHGKKKKLR 449

  Fly   443 C---EPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTG 504
            .   ..:..|..|...:|.........||||| :.|.| .:.|.|::...|
plant   450 VLVPAGNITPQILEVKTDFKTGVTAATGYCID-VFETS-ILPFNYEVEYIP-------------- 498

  Fly   505 AMTLRKEWTGLI-----GELV------NERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKK 558
                   |.|.|     .:||      .::.|..|..:||...|:.|::|:.||...|:.::..|
plant   499 -------WPGAINYKNYNDLVYTLYSQKDKYDAAVGDITITDNRSLYVDFTLPFTDMGLAVVTAK 556

  Fly   559 PSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKAL--NLSSA 621
             .:|..::  .:|.:.:||:.:.....:...:::|::|          |.:::.:.:.  .:.:.
plant   557 -DKSMWII--FKPLTLSLWLTIASFFILTGAIVWLIER----------HDNADFQGSCFQQIGTL 608

  Fly   622 VWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDAR 686
            :.|.:..|:.:. .|....:.| |.:.:||....:|:.::|||.|.:.:.::    ::.|:
plant   609 LCFGFSTLVFAH-RERLQHNMS-RFVVIVWIFAVLILTSNYTATLTSVMTVQ----QIRGL---- 663

  Fly   687 LRNTMENLTCATVKGSSVDMYFRRQV--ELSNMYRTMEANNY---ATAEQAIQDVKKGKLMAFIW 746
              .:.||:.           :|...:  .:.|...|.:...|   .||:.....::.|.: :||.
plant   664 --KSNENIG-----------FFSASIAANVVNDNPTFQGPRYKGLKTADDFTNALRNGTI-SFIV 714

  Fly   747 DS---SRLEYEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWI 808
            |.   .:| :.|....|.|........:|:|...|||||....|:..|.:...:..::.::..|.
plant   715 DEVPYVKL-FVAKHPSEFVIVETESVTNGFGFAFQKGSPLVQKVSREIEKLRRTEKLKAIENWWF 778

  Fly   809 FHGHVQQNCELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQ 860
               ..|......|.|.:.|.:....|:|::.||..|  ..||:..:.:.:.|
plant   779 ---QRQTTSATSEDTFHPLTVYTFRGLFMITGVSFA--FALIVYLIPWNREQ 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	72/351 (21%)
		ANF_receptor	58..371	CDD:279440	63/313 (20%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	80/424 (19%)
		HisJ	451..>558	CDD:223904	27/117 (23%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	26/147 (18%)
		Lig_chan	575..838	CDD:278489	50/272 (18%)
		CaM_bdg_C0	854..882	CDD:287524	1/7 (14%)
GLR1.4	NP_187408.2	PBP1_GABAb_receptor	47..410	CDD:107361	67/335 (20%)
		ANF_receptor	64..390	CDD:279440	64/314 (20%)
		GluR_Plant	448..778	CDD:270404	75/390 (19%)
		Periplasmic_Binding_Protein_Type_2	476..>657	CDD:304360	45/218 (21%)
		Lig_chan	570..810	CDD:278489	52/277 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010