DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and GLR1.1

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_187061.1	Gene:	GLR1.1 / 819566	AraportID:	AT3G04110	Length:	808	Species:	Arabidopsis thaliana

Alignment Length:	929	Identity:	184/929 - (19%)
Similarity:	334/929 - (35%)	Gaps:	248/929 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAMAEF------------VFCRPLFGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSEEH 53
            :|:::|            |..|...|..|:.|.|..|..:      |.....|.|  :.|..|..
plant    52 LALSDFYGINNGYRTRVSVLVRDSQGDPIIALAAATDLLK------NAKAEAIVG--AQSLQEAK 108

  Fly    54 FSTTIKHLNFDQQYVPRKVTYYDKTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPA 118
            ...||.    ::..||...|:...|:.:.|         .|..|:       .:|:.||
plant   109 LLATIS----EKAKVPVISTFLPNTLSLKK---------YDNFIQ-------WTHDTTS------ 147

  Fly   119 AVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSD 183
                       ...||:|....||.|::.|        .|..||.|.|.|.       |::.:..
plant   148 -----------EAKGITSLIQDFSCKSVVV--------IYEDADDWSESLQ-------ILVENFQ 186

  Fly   184 TDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLID----MKTAQSRVYLMYAST 244
            ..|                 :.:..:....|.     .|...|:::    :|.:::.|::::.|.
plant   187 DKG-----------------IYIARSASFAVS-----SSGENHMMNQLRKLKVSRASVFVVHMSE 229

  Fly   245 EDAQVIFRDAGEYNMTGEGHVWIVTEQAL-----FS-NNTPDGVLGLQ----------------- 286
            .....:|:...:..:..|...||:|.:.:     |: ..:..||:|.:
plant   230 ILVSRLFQCVEKLGLMEEAFAWILTARTMNYLEHFAITRSMQGVIGFKSYIPVSEEVKNFTSRLR 294

  Fly   287 ------LEHAHSD-----KGHIRDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESGKRLFQY 340
                  .|..||.     :.|  |...:||:|:::...:..:..:.....|          |...
plant   295 KRMGDDTETEHSSVIIGLRAH--DIACILANAVEKFSVSGKVEASSNVSAD----------LLDT 347

  Fly   341 LKSRNITGETGQVAFDDNGDRIYAGYDVINI-REQQKKHVVGKFSYDSMRAKMRMRINDSEIIWP 404
            ::.....|.:|.:...|| ..|...::::|| ||:|::  :|.:|..|...:       .:|:||
plant   348 IRHSRFKGLSGDIQISDN-KFISETFEIVNIGREKQRR--IGLWSGGSFSQR-------RQIVWP 402

  Fly   405 GKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGY- 468
            |:.|:      ||.|..|....||..:.|.....::.......||.|  .....|.:.||...:
plant   403 GRSRK------IPRHRVLAEKGEKKVLRVLVTAGNKVPHLVSVRPDP--ETGVNTVSGFCVEVFK 459

  Fly   469 -CIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLT 532
             ||         ..|.|:|...|      |...|:..|..|..:         .::.|..|..:|
plant   460 TCI---------APFNYELEFIP------YRGNNDNLAYLLSTQ---------RDKYDAAVGDIT 500

  Fly   533 INPERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRF 597
            |...|:.|::|:.|:...||.||..| .:|..:.:|..||..:||:.......:..:|::|::|
plant   501 ITSNRSLYVDFTLPYTDIGIGILTVK-KKSQGMWTFFDPFEKSLWLASGAFFVLTGIVVWLVER- 563

  Fly   598 SPFGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASY 662
            |....|:.|...       .||..:||.:..::.:  .....:..|:|.|.:||....:|:.:||
plant   564 SVNPEFQGSWGQ-------QLSMMLWFGFSTIVFA--HREKLQKMSSRFLVIVWVFVVLILTSSY 619

  Fly   663 TANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYA 727
            :|||          |....|:..:|.:.|      ...||:..|             |.:..:..
plant   620 SANL----------TSTKTISRMQLNHQM------VFGGSTTSM-------------TAKLGSIN 655

  Fly   728 TAEQAIQDVKKGKLMAFIWDSSRLEYEA----SKDCELVTAGELFGRSGYGIGLQKGSPWTDAVT 788
            ..|...|.::.|.|...|   :.:.|.:    :...:.|....:...:|:|...||||.....|:
plant   656 AVEAYAQLLRDGTLNHVI---NEIPYLSILIGNYPNDFVMTDRVTNTNGFGFMFQKGSDLVPKVS 717

  Fly   789 LAILEFHESGFMEKLDKQW---IFHGHVQQNCELFEKT------PNTLGLKNMAGVFILVGVGIA 844
            ..|.:....|.::.::|:|   :...:|..|.|....|      ......:.:.|:||:.|   |
plant   718 REIAKLRSLGMLKDMEKKWFQKLDSLNVHSNTEEVASTNDDDEASKRFTFRELRGLFIIAG---A 779

  Fly   845 GGVGLIIIEVIYKKHQVKK 863
            ..|.::.:.:.:.:.:|.:
plant   780 AHVLVLALHLFHTRQEVSR 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	77/431 (18%)
		ANF_receptor	58..371	CDD:279440	56/350 (16%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	90/409 (22%)
		HisJ	451..>558	CDD:223904	26/108 (24%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	32/134 (24%)
		Lig_chan	575..838	CDD:278489	55/275 (20%)
		CaM_bdg_C0	854..882	CDD:287524	1/10 (10%)
GLR1.1	NP_187061.1	PBP1_GABAb_receptor	31..397	CDD:107361	79/448 (18%)
		ANF_receptor	45..377	CDD:279440	71/419 (17%)
		Periplasmic_Binding_Protein_Type_2	421..737	CDD:304360	82/384 (21%)
		Lig_chan	542..781	CDD:278489	58/283 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.010