DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and GLR5

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_565744.1	Gene:	GLR5 / 817801	AraportID:	AT2G32400	Length:	921	Species:	Arabidopsis thaliana

Alignment Length:	934	Identity:	227/934 - (24%)
Similarity:	400/934 - (42%)	Gaps:	171/934 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LAIVLLVAPIDAAQRHTASDNPSTYNIGGVLS-----NSDSEEHFSTTIKHLNFDQQYVPRKVTY 74
            |.:|:||.|:| .||      |...|||.|.:     ...::......:..:|.|:.::  |.|
plant    14 LIVVILVVPMD-CQR------PQLVNIGAVFAFDSVIGRAAKVALEAAVSDVNNDKSFL--KET- 68

  Fly    75 YDKTIRMDK---NPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYT-----SGFYSIPV 131
             :..:.|:.   |..:..|...: |:|..|.|::       |.:| ::|::|     .|.: .|:
plant    69 -ELRLLMEDSACNVFRGSFGAFE-LLEKEVVAMI-------GPIS-SSVAHTISDIAKGLH-FPL 122

  Fly   132 IGISSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTT 196
            :..::.|...|...... ||||.|...||....:::::.:.:.:||.::|.|..||.  |.....
plant   123 VSFAATDPTLSALQFPF-FLRTTPNDAHQMSALVDLINFYGWKEVISVYSDDELGRN--GVSALD 184

  Fly   197 SQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTG 261
            .:.|.....:...|.|.|..:.|.  .|..|...|:...|||:::...:....||..|.:..|..
plant   185 DELYKKRSRISYKVPLSVHSDEKF--LTNALNKSKSIGPRVYILHFGPDPLLRIFDIAQKLQMMT 247

  Fly   262 EGHVWIVTE------QALFSNNT---PDGVLGL--------QLEH----AHSDKG------HIRD 299
            ..:||:.|:      .:|....|   .:||:||        ::||    ..|::.      |..|
plant   248 HEYVWLATDWLSVTLDSLSDKGTLKRLEGVVGLRQHIPESVKMEHFTHKLQSNRSMNAYALHAYD 312

  Fly   300 SVYVLASAIKEMISNETI------------AEAPKDCGDSAVNWESGKRLFQYLKSRNITGETGQ 352
            :|:::|..|:|:: ||.|            |...|...:....:.||:.|.:.|...|.||..||
plant   313 TVWMIAHGIEELL-NEGINITFSYSEKLLHARGTKLHLEKIKFFNSGELLLEKLLKVNFTGIAGQ 376

  Fly   353 VAFDDNGDRIYAGYDVINIREQQKKHVVGKFS----YDSMRAKMRMR------IND---SEIIWP 404
            |.|....:.|...|::||:.:.. .|.||.:|    :..:..|.|..      ::|   .:|.||
plant   377 VQFGSGRNVIGCDYEIINVNKTD-VHTVGFWSKNGGFSVVAPKTRHSQKKTSFVSDEKLGDITWP 440

  Fly   405 GKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYC 469
            |..|.||.|.:|......|.|     |..||:...||..|..       |:|..      .:|:|
plant   441 GGGREKPRGWVIADSADPLKI-----VVPRRVSFVEFVTEEK-------NSSHR------IQGFC 487

  Fly   470 IDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTIN 534
            ||:.||..|.:.::......|.|. ||           ....:..||..:.:...|..|..:.|.
plant   488 IDVFIEALKFVPYSVPYIFEPFGN-GH-----------SSPNYNHLIQMVTDGVYDAAVGDIAIV 540

  Fly   535 PERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSP 599
            |.|::.::||:|:...|:.::......::|.: ||:||::.||.:|:||..|:|:|:::|:.
plant   541 PSRSKLVDFSQPYASTGLVVVIPANDDNATWI-FLRPFTSRLWCVVLVSFLVIAVVIWILEH--- 601

  Fly   600 FGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTA 664
                 ..:.|........||:.:.|::..|.... .|.|..:. ||::.:||....|::.|||||
plant   602 -----RINEDFRGPPRRQLSTMLLFSFSTLFKRN-QEDTISNL-ARLVMIVWLFLLMVLTASYTA 659

  Fly   665 NLAAFLVLERPKTKLSGINDARLRN----------TMENLTCATVKGSSVDMYFRRQVELSNMYR 719
            ||.:.|.:::..:.::||:..|...          |:|.||      .|:.|...|.|.|.:
plant   660 NLTSILTVQQLPSAITGIDSLRASEVPIGYQAGTFTLEYLT------YSLGMARSRLVPLDS--- 715

  Fly   720 TMEANNYATAEQAIQ--DVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYGIGLQKGSP 782
               ...|   |:|::  ....|.:.|.:.:...:|...::.......||.|...|:|...::.||
plant   716 ---TEEY---EKALKLGPTNWGGVAAIVDELPYIELFLAERTGFKIVGEPFMHRGWGFAFKRDSP 774

  Fly   783 WTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNC---ELFEKTPNTLGLKNMAGVFILVGVGIA 844
            ....::.|||:..|:..::::.|:|:    .:.||   ..:...||.|.||:..|:::   |.||
plant   775 LAIDMSTAILKLSETRKLQEIRKKWL----CKTNCAGKSNWNPEPNQLHLKSFKGLYL---VCIA 832

  Fly   845 GGVGLIIIEVIYKKHQVKKQKRLD 868
            ..|...::.|:....|..:.:|::
plant   833 ITVSAFLVFVLRMIRQFVRYRRME 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	108/454 (24%)
		ANF_receptor	58..371	CDD:279440	85/359 (24%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	99/415 (24%)
		HisJ	451..>558	CDD:223904	24/106 (23%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	33/134 (25%)
		Lig_chan	575..838	CDD:278489	68/277 (25%)
		CaM_bdg_C0	854..882	CDD:287524	3/15 (20%)
GLR5	NP_565744.1	PBP1_GABAb_receptor	32..416	CDD:107361	94/404 (23%)
		ANF_receptor	46..396	CDD:279440	86/369 (23%)
		GluR_Plant	458..800	CDD:270404	96/397 (24%)
		Lig_chan	581..832	CDD:278489	69/282 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7187
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060