DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and GLR3.5

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001324013.1	Gene:	GLR3.5 / 817800	AraportID:	AT2G32390	Length:	953	Species:	Arabidopsis thaliana

Alignment Length:	997	Identity:	226/997 - (22%)
Similarity:	401/997 - (40%)	Gaps:	202/997 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MAEFVFCRPL---FGLAIV--LLVAPIDAAQRHTASDN------PSTYNIGGVLSNSD-----SE 51
            |..||..|.:   |.|..:  |.|.||..|.|.:.|.|      ||:.|:|.:.:...     ::
plant     1 MGFFVMIRDVSMGFMLLCISALWVLPIQGAGRESFSRNSSSSSLPSSVNVGALFTYDSFIGRAAK 65

  Fly    52 EHFSTTIKHLNFDQQYV---PRKVTYYDKTIRMDKNPIKTVFNVCD---------KLIENRVYAV 104
            ..|...|:.:|.||..:   ...:.:.|..              |.         :|:||:|.|.
plant    66 LAFVAAIEDINADQSILRGTKLNIVFQDTN--------------CSGFVGTMGALQLMENKVVAA 116

  Fly   105 VVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLS 169
            :.......|.:    :|:.:....:|.:..::.|...|... :..||||....|.|.:...:.:|
plant   117 IGPQSSGIGHI----ISHVANELHVPFLSFAATDPTLSSLQ-YPYFLRTTQNDYFQMNAITDFVS 176

  Fly   170 HFAYTKVIIIHSSDTDGR---AILGRFQTTSQTYYDDVDVRATVELIVEFEPKLE--SFTEHLID 229
            :|.:.:|:.|...|..||   ::||......         ||.:.....|.|..:  |.::.|..
plant   177 YFRWREVVAIFVDDEYGRNGISVLGDALAKK---------RAKISYKAAFPPGADNSSISDLLAS 232

  Fly   230 MKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQAL--------------------- 273
            :...:||:::::.:.:....||..|....|.|.|:|||.|:..|
plant   233 VNLMESRIFVVHVNPDSGLNIFSVAKSLGMMGSGYVWITTDWLLTALDSMEPLDPRALDLLQGVV 297

  Fly   274 -FSNNTPDGVLGLQL----------EHAHSDKG------HIRDSVYVLASAIKEMIS---NETIA 318
             |.:.||:.....|.          |...||.|      :..|||:::|.|:....|   ..|.:
plant   298 AFRHYTPESDNKRQFKGRWKNLRFKESLKSDDGFNSYALYAYDSVWLVARALDVFFSQGNTVTFS 362

  Fly   319 EAP--KDCGDSAVN------WESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQ 375
            ..|  ::..||.:.      :..|:|..|.:...|.||.|||:.|:...:||...||::||:...
plant   363 NDPSLRNTNDSGIKLSKLHIFNEGERFLQVILEMNYTGLTGQIEFNSEKNRINPAYDILNIKSTG 427

  Fly   376 KKHV------VG--------KFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIE 426
            ...|      .|        .:|..|..:....|:|  ||||||:..:.|.|.:.|.:.:.|.|.
plant   428 PLRVGYWSNHTGFSVAPPETLYSKPSNTSAKDQRLN--EIIWPGEVIKPPRGWVFPENGKPLKIG 490

  Fly   427 EKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPD 491
            ....|..:                   |.:....|....:|:|||:         |...:.|.|.
plant   491 VPNRVSYK-------------------NYASKDKNPLGVKGFCIDI---------FEAAIQLLPY 527

  Fly   492 GQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILE 556
            .....|||   .|.......:..||.|:.....|:.|..:||...|.::::|::||...|:.::.
plant   528 PVPRTYIL---YGDGKKNPSYDNLISEVAANIFDVAVGDVTIITNRTKFVDFTQPFIESGLVVVA 589

  Fly   557 KKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEE----KALN 617
            ......|:..|||:||:..:|.:.......|..|:::|:.     ||       |||    ....
plant   590 PVKGAKSSPWSFLKPFTIEMWAVTGALFLFVGAVIWILEH-----RF-------NEEFRGPPRRQ 642

  Fly   618 LSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGI 682
            :.:..||::..:..|. .|.|..:....|| :||....:||.:||||:|.:.|.:::..:::.|:
plant   643 IITVFWFSFSTMFFSH-RENTVSTLGRFVL-LVWLFVVLIINSSYTASLTSILTVQQLTSRIEGM 705

  Fly   683 NDARLRNTMENLTCATVKGSSVDMYFRRQVEL--SNMYRTMEANNYATAEQAIQDVKKGKLMAFI 745
            :..    ...|.......|:....:...::.:  |.:....:...|.:   |:|...:|..:|.|
plant   706 DTL----IASNEPIGVQDGTFAWKFLVNELNIAPSRIIPLKDEEEYLS---ALQRGPRGGGVAAI 763

  Fly   746 WDSSRLEY----EASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQ 806
            .|  .|.|    .::.:|:..|.|:.|.|:|:|...|:.||....::.|||:..|.|.:||:.|:
plant   764 VD--ELPYIKALLSNSNCKFRTVGQEFTRTGWGFAFQRDSPLAVDMSTAILQLAEEGKLEKIRKK 826

  Fly   807 WIFHGHVQQNCEL-FEKTPN-TLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDI 869
            |:.:.|   .|.: ...|.| .:.:::..|:|::.||.....:.|...:|.::..:::.::..::
plant   827 WLTYDH---ECTMQISDTENYQISVQSFWGLFLICGVVWFIALTLFCWKVFWQYQRLRPEESDEV 888

  Fly   870 ARHA--ADKWRGTIEKRKTIRA 889
            ...:  |...||     |::||
plant   889 QARSEEAGSSRG-----KSLRA 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	109/488 (22%)
		ANF_receptor	58..371	CDD:279440	82/378 (22%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	94/410 (23%)
		HisJ	451..>558	CDD:223904	25/106 (24%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	33/138 (24%)
		Lig_chan	575..838	CDD:278489	64/274 (23%)
		CaM_bdg_C0	854..882	CDD:287524	4/29 (14%)
GLR3.5	NP_001324013.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060