DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and GLR2.7

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_180476.3	Gene:	GLR2.7 / 817460	AraportID:	AT2G29120	Length:	952	Species:	Arabidopsis thaliana

Alignment Length:	944	Identity:	203/944 - (21%)
Similarity:	373/944 - (39%)	Gaps:	196/944 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FVFCRPLFGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSEEHFSTTIKHLNFDQQYVPR 70
            |::...||....||:...:  .|..|     :...:|.||....|......|..:::....|
plant    13 FMYYFVLFVCGFVLMEGCL--GQNQT-----TEIKVGVVLDLHTSFSKLCLTSINISLSDFY--- 67

  Fly    71 KVTYY-DKTIRMDKNPIKTVFNVCDKLIENRVYAV-----VVSHEQTSGDLSPAAVSYTSGFYSI 129
              .|: |.|.|:       ..::.|.: |:.|.|.     ::.:||.|..:.|.
plant    68 --KYHSDYTTRL-------AIHIRDSM-EDVVQASSAALDLIKNEQVSAIIGPR----------- 111

  Fly   130 PVIGISSRDAAF----SDKN--IHVSFLRTVP-------PYY--------HQADVWLEMLSHFAY 173
                 :|..|.|    :||:  ..::|..|.|       ||:        .|......::..|.:
plant   112 -----TSMQAEFMIRLADKSQVPTITFSATCPLLTSINSPYFVRATLDDSSQVKAIAAIVKSFGW 171

  Fly   174 TKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATV--ELIVEFEPKLESFTEHLIDMKTAQSR 236
            ..|:.|:..:..|..||.......|      ||:|.|  ..::..|...:...:.|..:.|.|:|
plant   172 RNVVAIYVDNEFGEGILPLLTDALQ------DVQAFVVNRCLIPQEANDDQILKELYKLMTMQTR 230

  Fly   237 VYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTE---QALFSN------NTPDGVLG-------- 284
            |::::.........|:.|.|..|..||:||::|:   ..|.||      ....||||
plant   231 VFVVHMPPTLGFRFFQKAREIGMMEEGYVWLLTDGVMNLLKSNERGSSLENMQGVLGVRSHIPKS 295

  Fly   285 -------LQLEHAHSDKGH--------IR--DSVYVLASAIKEMISNETIAEAPKDCGDSAVNWE 332
                   |:.|.....||:        :|  ||:..||.|:::........:.|...|::..|..
plant   296 KKLKNFRLRWEKMFPKKGNDEEMNIFALRAYDSITALAMAVEKTNIKSLRYDHPIASGNNKTNLG 360

  Fly   333 S------GKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHVVGKF--SYDSMR 389
            :      |..|.:.|.:....|..|:... .||....:.:|||||...::: ::|.:  |...:.
plant   361 TLGVSRYGPSLLKALSNVRFNGLAGEFEL-INGQLESSVFDVINIIGSEER-IIGLWRPSNGIVN 423

  Fly   390 AKMRMRINDSE--------IIWPGKQRRKPEGIMIPTHLRLLTI---EEKPFVYVRRMGDDEFRC 443
            ||.:   |.:.        :|||||.:..|:|..|||:.::|.:   .:|.|:        ||
plant   424 AKSK---NTTSVLGERLGPVIWPGKSKDVPKGWQIPTNGKMLRVGIPVKKGFL--------EF-- 475

  Fly   444 EPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFT----YDLALSPDGQFGHYILRNNTG 504
             .|.:..|:.|....|       ||||::...:.|::.::    |...||||..:...:.:..||
plant   476 -VDAKIDPISNAMTPT-------GYCIEIFEAVLKKLPYSVIPKYIAFLSPDENYDEMVYQVYTG 532

  Fly   505 AMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFL 569
            |.                  |.:|..:||...|:.|::|:.|:...|::::.......:|.| ||
plant   533 AY------------------DAVVGDVTIVANRSLYVDFTLPYTESGVSMMVPLKDNKNTWV-FL 578

  Fly   570 QPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGI 634
            :|:|..||:........:..::::|:.        ..::|........:.::.|||:.. :|...
plant   579 RPWSLDLWVTTACFFVFIGFIVWILEH--------RVNTDFRGPPHHQIGTSFWFAFST-MNFAH 634

  Fly   635 GEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATV 699
            .|....:. ||.:.:||....::::.||||||.:|..::..:..::...|.    ...|......
plant   635 REKVVSNL-ARFVVLVWCFVVLVLIQSYTANLTSFFTVKLLQPTVTNWKDL----IKFNKNIGYQ 694

  Fly   700 KGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTA 764
            :|:     |.|::..|..:...:...:.:|.:..:....|.:.|...:.:.::...|::....|.
plant   695 RGT-----FVRELLKSQGFDESQLKPFGSAVECDELFSNGTITASFDEVAYIKVILSQNSSKYTM 754

  Fly   765 GE-LFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEK--TPNT 826
            .| .|..:|:|....|.||.||.|:.|||...:...|:.::.:|.   ....||.....  :.|.
plant   755 VEPSFKTAGFGFVFPKKSPLTDDVSRAILNVTQGEEMQHIENKWF---KKPNNCPDLNTSLSSNH 816

  Fly   827 LGLKNMAGVFILVGVGIAGGVGLIIIEVIYK-KH 859
            |.|.:..|:|::.|:.....:.:.:...:|: ||
plant   817 LSLSSFWGLFLIAGIASFLALLIFVANFLYEHKH 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	100/471 (21%)
		ANF_receptor	58..371	CDD:279440	80/381 (21%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	86/408 (21%)
		HisJ	451..>558	CDD:223904	25/110 (23%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	26/134 (19%)
		Lig_chan	575..838	CDD:278489	53/265 (20%)
		CaM_bdg_C0	854..882	CDD:287524	3/7 (43%)
GLR2.7	NP_180476.3	PBP1_GABAb_receptor	40..421	CDD:107361	89/417 (21%)
		ANF_receptor	54..405	CDD:279440	82/386 (21%)
		GluR_Plant	460..799	CDD:270404	82/394 (21%)
		Lig_chan	584..832	CDD:278489	54/269 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010