DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and GLR2.9

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001325277.1	Gene:	GLR2.9 / 817458	AraportID:	AT2G29100	Length:	942	Species:	Arabidopsis thaliana

Alignment Length:	958	Identity:	190/958 - (19%)
Similarity:	368/958 - (38%)	Gaps:	239/958 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 VVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIH------VSFLRTVP-------P 156
            ::..||.|..:.|                |:|..|.|..|..:      ::|..|.|       |
plant    91 LIKTEQVSAIIGP----------------INSMQADFMIKLANKTQVPTITFSATSPLLTSIKSP 139

  Fly   157 YYHQADV--------WLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATV--- 210
            |:.:|.:        ...:...|.:.:|:.|:..:..|...:.......|    ||:|:.:|
plant   140 YFVRATIDDSSQVRAIASIFKFFRWRRVVAIYVDNEFGEGFMPFLFDALQ----DVEVKRSVIPP 200

  Fly   211 ELI-VEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALF 274
            |.| .|.:.:|....|.       |:||::::..:..|..:|:.|.:..|..||:||::|.....
plant   201 EAIDDEIQKELRKLMER-------QARVFVVHMESSLALRVFQIARDIGMMEEGYVWLMTNGMTH 258

  Fly   275 ---------SNNTPDGVLGLQLEHAHSDK--GHIR--------------------------DSVY 302
                     |.||.:||||:: .|....|  |..|                          ||:.
plant   259 MMRHINNGRSLNTIEGVLGVR-SHVPKSKELGDFRLRWKRTFEKENPSMRDDLNVFALWAYDSIT 322

  Fly   303 VLASAIKE-------MISNETIAEAPKDCGDSAVN--WESGKRLFQYLKSRNITGETGQVAFDDN 358
            .||.|:::       ..:..|:::...|.|:..|:  ..|.::.|..::...:.||...:    :
plant   323 ALAKAVEKANTKSLWYDNGSTLSKNRTDLGNVGVSLYGPSLQKAFSEVRFNGLAGEFKLI----D 383

  Fly   359 GDRIYAGYDVINIREQQKKHVVGKFSYDS--MRAKMRMRINDSEIIWPGKQRRKPEGIMIP-THL 420
            |......:::||....::: ::|.::...  |.|....:.....:|||||.:..|:|..|| ..|
plant   384 GQLQSPKFEIINFVGNEER-IIGFWTPRDGLMDATSSNKKTLGPVIWPGKSKIVPKGWEIPGKKL 447

  Fly   421 RLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDL----LIELSKRIN 481
            |:....:|.|....::..:           |:.|....|       ||.|::    |.||...:.
plant   448 RVGVPMKKGFFDFVKVTIN-----------PITNKKTPT-------GYAIEIFEAALKELPYLVI 494

  Fly   482 FTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKP 546
            ..|....||          ||         :..|:.::.::..|.:|..:||...|:.|.:|:.|
plant   495 PEYVSFESP----------NN---------YNNLVYQVYDKTWDAVVGDITITANRSLYADFTLP 540

  Fly   547 FKYQGITILEKKPSRSS----TLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSH 607
            |...|::::  .|.|.:    |.| ||:|:|..||:........:..|::|.:.        ..:
plant   541 FTESGVSMM--VPVRDNENKDTWV-FLEPWSLELWVTTGCFFVFIGFVVWLFEH--------RVN 594

  Fly   608 SDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFS---------ARVLGMVWAGFAMIIVASYT 663
            :|........:.:::||::..::           |:         ||.:.:||....:::..|||
plant   595 TDFRGPPQYQIGTSLWFSFSTMV-----------FAHRENVVSNLARFVVVVWCFVVLVLTQSYT 648

  Fly   664 ANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYAT 728
            |:|.:||.::..:..::.:||     .::|..|...:|.:    |.:.:.|...:...:...:.:
plant   649 ASLTSFLTVQSLQPTVTNVND-----LIKNRDCVGYQGGA----FVKDILLGLGFHEDQLKPFDS 704

  Fly   729 AEQAIQDVKKGK---LMAFIWDSSRLEYEASKDC-ELVTAGELFGRSGYGIGLQKGSPWTDAVTL 789
            |:.|...:.|||   :.|...:.:.|:...|:.| :.|.....|...|:|....|.||.|...:.
plant   705 AKDADDLLSKGKSKGIAAAFDEVAYLKAILSQSCSKYVMVEPTFKTGGFGFAFPKNSPLTGEFSR 769

  Fly   790 AILEFHESGFMEKLDKQWIFHGHVQQNC--ELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIII 852
            |||...::...::::.:|.   ..:.:|  .:...:.|.|.|.:..|:|::.|..|:..: |:.:
plant   770 AILNLTQNNVTQQIEDRWF---PKKNDCPDPMTALSSNRLNLSSFLGLFLIAGTAISFSL-LVFV 830

  Fly   853 EVIYKKHQVKKQKRLDIARHAADK-WR------GTIEKRKTIRASLAMQRQYNVGLNSTH---AP 907
            .:...:|      |..:...:.|. ||      ...:::.....:......:|:....||   :|
plant   831 ALFLYEH------RHTLGDDSEDSLWRKLKFLFKIFDEKDMNSHTFKNSAIHNISSPMTHKTPSP 889

  Fly   908 GTISLAVDKRRYPRLGQRLGPERAWPGDAADVLRIRRPYELGNPGQSP 955
            .|:.:.                 .||...:.    .|.:||.....||
plant   890 STVQIT-----------------PWPQSPSQ----NREFELRRVSFSP 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	73/372 (20%)
		ANF_receptor	58..371	CDD:279440	67/336 (20%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	86/424 (20%)
		HisJ	451..>558	CDD:223904	25/110 (23%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	28/147 (19%)
		Lig_chan	575..838	CDD:278489	53/277 (19%)
		CaM_bdg_C0	854..882	CDD:287524	5/34 (15%)
GLR2.9	NP_001325277.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010