DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and GLR2.2

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_180048.1	Gene:	GLR2.2 / 817008	AraportID:	AT2G24720	Length:	920	Species:	Arabidopsis thaliana

Alignment Length:	1014	Identity:	211/1014 - (20%)
Similarity:	366/1014 - (36%)	Gaps:	277/1014 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAMAEFVFCRPLFGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSEEHFSTTIKHLNFDQ 65
            |::|:|...||.|...:|:                    |:|      ||
plant    54 MSLADFYSSRPQFQTRLVV--------------------NVG------DS--------------- 77

  Fly    66 QYVPRKVTYYDKTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTS------ 124
                             ||.:.........||:|:         |....|.|    :||
plant    78 -----------------KNDVVGAATAAIDLIKNK---------QVKAILGP----WTSMQAHFL 112

  Fly   125 ---GFYS-IPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSH--------FAYTKVI 177
               |..| :||:..|:...:.:.       ||:  ||:.:|........|        |.:.:|:
plant   113 IEIGQKSRVPVVSYSATSPSLTS-------LRS--PYFFRATYEDSSQVHAIKAIIKLFGWREVV 168

  Fly   178 IIHSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYA 242
            .::..:|.|..|:.|...:.|    |::||.....::......:..:..|:.|....:||::::.
plant   169 PVYIDNTFGEGIMPRLTDSLQ----DINVRIPYRSVIPLNATDQDISVELLKMMNMPTRVFIVHM 229

  Fly   243 STEDAQVIFRDAGEYNMTGEGHVWIVTE---QALFSNN-----TPDGVLGLQLEHAHS-DKGHIR 298
            |:..|..:|..|.|..:...|:|||:|.   ..|.|.|     ..:||||::.....| |....|
plant   230 SSSLASTVFIKAKELGLMKPGYVWILTNGVMDGLRSINETGIEAMEGVLGIKTYIPKSKDLETFR 294

  Fly   299 --------------------DSVYVLASAIKEM-ISNETIAEAPKDCGDSAVNWES------GKR 336
                                |:...||.||::. |:|.|.:..  |.|.:....:.      |.:
plant   295 SRWKRRFPQMELNVYGLWAYDATTALAMAIEDAGINNMTFSNV--DTGKNVSELDGLGLSQFGPK 357

  Fly   337 LFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINI-------------------REQQKKHVVGK 382
            |.|.:.:....|..|...| .:|....:.::::|:                   :..|:...:|.
plant   358 LLQTVSTVQFKGLAGDFHF-VSGQLQPSVFEIVNMIGTGERSIGFWTEGNGLVKKLDQEPRSIGT 421

  Fly   383 FSY--DSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEP 445
            .|.  |.::          .|||||:....|:|..|||:.:.|.|.     ..:|:|..:.
plant   422 LSTWPDHLK----------HIIWPGEAVSVPKGWEIPTNGKKLRIG-----VPKRIGFTDL---- 467

  Fly   446 DERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLAL------SPDGQFGHYILRNNTG 504
                  :....|...|....:|:|||....:.:.:  .||::.      .|:|
plant   468 ------VKVTRDPITNSTVVKGFCIDFFEAVIQAM--PYDVSYEFFPFEKPNG------------ 512

  Fly   505 AMTLRKEWTGLIGELVNE----RADMIVAPLTINPERAEYIEFSKPFKYQGI-TILEKKPSRSST 564
                  |..|...:||::    :.|.:|...||...|:.:::|:.||...|: .|:..|......
plant   513 ------EPAGNHNDLVHQVYLGQFDAVVGDTTILANRSSFVDFTLPFMKSGVGLIVPLKDEVKRD 571

  Fly   565 LVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGVL 629
            ..|||:|.|..||:..:|...:|.:.::.|:.        ..:||.........|:..|||:..:
plant   572 KFSFLKPLSIELWLTTLVFFFLVGISVWTLEH--------RVNSDFRGPANYQASTIFWFAFSTM 628

  Fly   630 LNSGIGEGTPR----SFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNT 690
            :.:      ||    ||.||.|.:.|....:::..||||:||:.|..:            :|..|
plant   629 VFA------PRERVLSFGARSLVVTWYFVLLVLTQSYTASLASLLTSQ------------QLNPT 675

  Fly   691 MENLTCATVKGSSVDMYFRRQVELSNMYRTMEANN----YATAEQAIQDVKKGK----LMAFIWD 747
            :.:::....:|.:|. |.|....|..:..|....:    :.|||:..:.:|||.    :.|....
plant   676 ITSMSSLLHRGETVG-YQRTSFILGKLNETGFPQSSLVPFDTAEECDELLKKGPKNGGVAAAFLG 739

  Fly   748 SSRLEYEASKDCELV-TAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHG 811
            :..:.....:.|... ...|.|...|:|.....|||....|:.|||:..||....:|:..|.  .
plant   740 TPYVRLFLGQYCNTYKMVEEPFNVDGFGFVFPIGSPLVADVSRAILKVAESPKAVELEHAWF--K 802

  Fly   812 HVQQNCELFEKTPNT--------LGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRL- 867
            ..:|:|......|::        ||:.:...:|::|.|.....:|......::|    .|.|.|
plant   803 KKEQSCPDPVTNPDSNPTVTAIQLGVGSFWFLFLVVFVVCVLALGKFTFCFLWK----TKGKDLW 863

  Fly   868 -DIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLNSTH 905
             :..:...|.:...|||   ...|..|....|...|.|:
plant   864 KEFLKRDTDSYINDIEK---CLCSQEMPENSNKATNQTN 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	86/467 (18%)
		ANF_receptor	58..371	CDD:279440	72/366 (20%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	94/424 (22%)
		HisJ	451..>558	CDD:223904	24/117 (21%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	36/143 (25%)
		Lig_chan	575..838	CDD:278489	63/283 (22%)
		CaM_bdg_C0	854..882	CDD:287524	5/29 (17%)
GLR2.2	NP_180048.1	PBP1_GABAb_receptor	33..412	CDD:107361	84/444 (19%)
		ANF_receptor	47..392	CDD:279440	84/424 (20%)
		HisJ	438..>587	CDD:223904	41/183 (22%)
		GluR_Plant	452..801	CDD:270404	90/410 (22%)
		Lig_chan	582..819	CDD:278489	60/265 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010