DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and GLR2

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001318239.1	Gene:	GLR2 / 816231	AraportID:	AT2G17260	Length:	925	Species:	Arabidopsis thaliana

Alignment Length:	844	Identity:	173/844 - (20%)
Similarity:	351/844 - (41%)	Gaps:	192/844 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 KLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYYH 159
            :.:|..|.|::  ..|||  :....:|:.:...::|::..::.|...|...... |::|.|
plant    93 QFMETDVVAII--GPQTS--IMAHVLSHLANELTVPMLSFTALDPTLSPLQFPF-FVQTAP---- 148

  Fly   160 QADVWL-----EMLSHFAYTKVIIIHSSDTDGR---AILG------RFQTTSQTYYD-DVDVRAT 209
             :|::|     ||::::.::.|:.:::.|.:.|   ..||      |.:.:.:.... ||.:.:.
plant   149 -SDLFLMRAIAEMITYYGWSDVVALYNDDDNSRNGVTALGDELEERRCKISYKAVLPLDVVITSP 212

  Fly   210 VELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTE--QA 272
            ||:|           |.||.::..:|||.::.......::||::|....|..:|:|||.|.  .:
plant   213 VEII-----------EELIKIRGMESRVIVVNTFPNTGKMIFKEAERLGMMEKGYVWIATTWLSS 266

  Fly   273 LFSNNTP------DGVLGLQLEHAHSDKG------------------------HIRDSVYVLASA 307
            :..:|.|      :|||.|:|....|.|.                        :..|:|:::|.|
plant   267 VLDSNLPLDTKLVNGVLTLRLHTPDSRKKRDFAARWKNKLSNNKTIGLNVYGLYAYDTVWIIARA 331

  Fly   308 IKEMI--------SNETIAEAPKDCGDSAVN------WESGKRLFQYLKSRNITGETGQVAFDDN 358
            :|.::        ||:....:.|   ..|:|      ::.|.:|..|:....::|.||.|.|..:
plant   332 VKTLLEAGGNLSFSNDAKLGSLK---GEALNLSALSRFDQGSQLLDYIVHTKMSGLTGPVQFHPD 393

  Fly   359 GDRIYAGYDVINIREQQKKHVVGKFS-YDSM--------------RAKMRMRINDSEIIWPGKQR 408
            ...:...||:||:.: .:.|.:|.:| |..:              |:.....:|  .:.|||...
plant   394 RSMLQPSYDIINLVD-DRVHQIGYWSNYSGLSIVPPESFYSKPPNRSSSNQHLN--SVTWPGGTS 455

  Fly   409 RKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLF-NNSDATANEFCCRGYCIDL 472
            ..|.|.:...:.|.|           |:|      .||......| :..:.::|:  .:|||||:
plant   456 VTPRGWIFRNNGRRL-----------RIG------VPDRASFKDFVSRVNGSSNK--VQGYCIDV 501

  Fly   473 LIELSKRINF--TYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINP 535
            .....|.:::  .::.....||      |.|......:.|..||:       ..|.:|..:.|..
plant   502 FEAAVKLLSYPVPHEFIFFGDG------LTNPNYNELVNKVTTGV-------DFDAVVGDIAIVT 553

  Fly   536 ERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPF 600
            :|...::|::|:...|:.::......:....:||:||:..:|.:......:|...:::|:
plant   554 KRTRIVDFTQPYIESGLVVVAPVTRLNENPWAFLRPFTLPMWAVTASFFVIVGAAIWILE----- 613

  Fly   601 GRFKLSHSDSNEEKA---LNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASY 662
                  |..::|.:.   ..:.:.:||.:..:..|  ...|..|...|::.::|....:||.:||
plant   614 ------HRINDEFRGPPRRQIITILWFTFSTMFFS--HRETTVSTLGRMVLLIWLFVVLIITSSY 670

  Fly   663 TANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVK-----GSSVDMYFRRQVEL--SNMYRT 720
            ||:|.:.|.:::..:.:.|:         :.|..:|.:     ||..:.|...::.:  |.:...
plant   671 TASLTSILTVQQLNSPIKGV---------DTLISSTGRIGFQVGSFAENYMTDELNIASSRLVPL 726

  Fly   721 MEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYGIGLQKGSPWTD 785
            .....||.|      ::.|.:.|.:.:...::...|..|:....|:.|.|.|:|....:.||...
plant   727 ASPEEYANA------LQNGTVAAIVDERPYIDLFLSDYCKFAIRGQEFTRCGWGFAFPRDSPLAV 785

  Fly   786 AVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPN--------TLGLKNMAGVFILVGV 841
            .::.|||...|:|.::|:..:|:    .:.||    .:|:        .|.:.:..|:|::||:
plant   786 DMSTAILGLSETGELQKIHDRWL----SKSNC----SSPHGSQSGDSEQLNVHSFWGMFLVVGI 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	81/385 (21%)
		ANF_receptor	58..371	CDD:279440	73/336 (22%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	81/413 (20%)
		HisJ	451..>558	CDD:223904	22/109 (20%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	22/137 (16%)
		Lig_chan	575..838	CDD:278489	54/280 (19%)
		CaM_bdg_C0	854..882	CDD:287524
GLR2	NP_001318239.1	PBP1_GABAb_receptor	35..424	CDD:107361	78/355 (22%)
		GluR_Plant	468..808	CDD:270404	79/399 (20%)
		Lig_chan	594..843	CDD:306551	56/284 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010