Protein Alignment Nmdar1 and grik5

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: NP_001315085.1
• Gene: grik5 / 798791
• ZFINID: ZDB-GENE-070821-6
• Length: 1067
• Species: Danio rerio
• Alignment Length: 1059
• Identity: 265/1059 - (25%)
• Similarity: 427/1059 - (40%)
• Gaps: 264/1059 - (24%)

  Fly    40 NIGGVLSNSDSEEHFSTTIKHLNFDQQYVPRKVTYYDKTIRMDKNPIKTVFNVCDKLIENRVYAV 104
            ||..|:.| .:.......|..|..|.||                   :|...:|..|.:..|..:
Zfish    63 NINSVMEN-PARARVEVDIFELQKDSQY-------------------ETTDTMCQILPKGVVSVI 107

  Fly   105 VVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLR--TVPPYYHQADVWL-- 165
            ..:....||.:    ||:..|...||.:.|...:..      .:.:||  :|..|....|:.|
Zfish   108 GPASSPASGSI----VSHICGEKEIPHVKIGPEETP------RLPYLRFASVTLYPSNEDLSLAI 162

  Fly   166 -EMLSHFAYTKV--------IIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLE 221
             .:|..|:|...        .::...:...|.::.| :|.|....||           ..:|
Zfish   163 GSILRSFSYPSASLVCAKAECLLRLEELIRRFLISR-ETLSIRMLDD-----------NLDP--- 212

  Fly   222 SFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVT--------------EQ- 271
              |..|.:::..:....::.|:...:.:|.:.|.|..||...:.:|:|              ||
Zfish   213 --TPLLKEIRDDKIATIIIDANASISYLILKKASELGMTSAFYKYILTTMDFPLLWLDDIVDEQS 275

  Fly   272 -----ALFSNNTP---DGVLGLQLEHAHS-----------DKGHIRDSVYVLASAIKEMISNETI 317
                 ::|:...|   :.:..|.|.....           ....:.|:|:|:.||::|:..::.|
Zfish   276 NIVGFSMFNTTHPFYLEFIRSLNLSWREGCDINPYPGPALSSALLFDAVHVVVSAVQELNRSQEI 340

  Fly   318 AEAPKDCGDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHVVGK 382
            ...|..|....: |:.|..|..||:.....|.||:|.|:..|.|  ..|.:..:.:.:..|....
Zfish   341 GVKPLSCTSPQI-WQHGTSLMNYLRMVEYDGLTGRVEFNSKGQR--TNYTLHILEKHRGGHKEIG 402

  Fly   383 FSYDSMRAKMR---MRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCE 444
            ..|.:....|.   :.||.||             .:....|.:.||.|.|:| :|::...||  |
Zfish   403 IWYSNNTLLMNSTSLDINVSE-------------TLANKSLIITTILENPYV-MRKINYQEF--E 451

  Fly   445 PDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLR 509
            .:|:                ..|:|:|:|.|||..:.|||.:.|..||.:         ||....
Zfish   452 GNEQ----------------YEGFCVDMLRELSDILKFTYRIKLVDDGLY---------GAPEPN 491

  Fly   510 KEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITIL-----EKKPSRSSTLVSFL 569
            ..|||::|||:|.:||:.||..||..||.:.|:|||||...||:||     .:||.    ..|||
Zfish   492 GSWTGMVGELINRKADLAVAAFTITSEREKVIDFSKPFMTLGISILYRVHIGRKPG----YFSFL 552

  Fly   570 QPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKAL-----NLSSAVWFAWGVL 629
            .|||..:|:.::::...|:.||:|..|.||:..:. .|....|.:.|     .|.:::||..|..
Zfish   553 DPFSPAVWLFMLLAYLAVSCVLFLSARLSPYEWYN-PHPCLRERRDLLENQYTLGNSLWFPVGGF 616

  Fly   630 LNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENL 694
            :..| .|..||:.|.|.:..||..|.:||::||||||||||.::|.:..:...:|..   ...|:
Zfish   617 MQQG-SEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESPDDLA---DQTNI 677

  Fly   695 TCATVKGSSVDMYFRRQVELSNMYRTMEAN-NY----------ATAEQAIQDVKKGKLMAFIWDS 748
            ...|:.|.|...:|     :::.|:|.:.. ||          .:.|:.|..|...| .||:.:|
Zfish   678 QYGTIHGGSTMTFF-----MNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVVNSK-YAFLLES 736

  Fly   749 SRLEYEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHV 813
            :..||..|.:|.|...|.|....|||||:..|||:.|.::||:|:..|:..:|.|.::|...|
Zfish   737 TMNEYHRSLNCNLTQIGGLLDTKGYGIGMPLGSPFRDELSLAVLQLQENNRLEILKRRWWEGG-- 799

  Fly   814 QQNCELFEKTPNT-------LGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIAR 871
                    |.|..       ||::|:.|:|:::..|:...|.:.::|.::.            .|
Zfish   800 --------KCPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFVWS------------TR 844

  Fly   872 HAADKWRGTIEKRKTIRASLAMQRQYNVGLNSTHAPGTISL----------AVDKRRYPRLGQR- 925
            .:|:    |.|.|     .|:..|||       |:..|:|:          ||..::..||.:|
Zfish   845 RSAE----TDEVR-----PLSCDRQY-------HSHTTVSVCQEMLTEFRNAVSCKKSSRLRRRR 893

  Fly   926 --------LGPERAWPGDAADVLRIRRPYELGN---------------PGQSPKVMAANQPG--- 964
                    ..|.|...| |...||:.|...|.|               ||..|..|.   ||
Zfish   894 PLSSSLALRHPTRITLG-APRPLRLVREMRLSNGKLYSGTGPLTGGSGPGGGPTDMG---PGPQR 954

  Fly   965 -MPMPMLGKTRPQQSVLPP 982
             :..|:...:.|..::.||
Zfish   955 LLEDPLGANSTPAVALGPP 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	82/414 (20%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	137/421 (33%)
		CaM_bdg_C0	854..882	CDD:402271	3/27 (11%)
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	36..414	CDD:380616	78/400 (20%)
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:473866	136/412 (33%)