DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and grin1

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	XP_012825220.1	Gene:	grin1 / 780048	XenbaseID:	XB-GENE-494200	Length:	941	Species:	Xenopus tropicalis

Alignment Length:	911	Identity:	427/911 - (46%)
Similarity:	601/911 - (65%)	Gaps:	60/911 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LFGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSEEHFSTTIKHLNFDQQYVPRKVTYYD 76
            ||.||::.|.:      ...|..:|...|||.|||....|:.|...:...|  :::...|:....
Frog     6 LFLLAVLFLFS------FARAGCDPKIVNIGAVLSTKKHEQIFREAVNQAN--KRHGTWKIQLNA 62

  Fly    77 KTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGD-LSPAAVSYTSGFYSIPVIGISSRDAA 140
            .::....|.|:...:||:.||.::|||::|||.....| |:|..:|||:|||.|||||:::|.:.
Frog    63 TSVTHRPNAIQMALSVCEDLISSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSI 127

  Fly   141 FSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQT--------TS 197
            :|||:||:|||||||||.|||.||.||:..|.:..||:|.|.|.:|||...:.:|        :.
Frog   128 YSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEKESKSK 192

  Fly   198 QTYYDDVDVRA-------TVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAG 255
            :..|:::|..:       ..:.:::|||..::.|..|::.|..::||.::.||.:||..:::.|.
Frog   193 KRNYENLDQLSYDNKRGPKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAA 257

  Fly   256 EYNMTGEGHVWIVTEQALFSN---NTPDGVLGLQLEHAHSDKGHIRDSVYVLASAIKEMISNETI 317
            ..:|||.|:||:|.|:.:..:   ..|||::||||.:..::..||.|:|.|.|.||.|:...|.|
Frog   258 MLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESAHISDAVAVAAQAIHELFEMENI 322

  Fly   318 AEAPKDCGDSAVNWESG---KRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHV 379
            .:.|:.|..:...|::|   ||:.  :.|:...|.||::.|:::|||.:|.|.::|:  |.:|.|
Frog   323 TDPPRGCVGNTNIWKTGPLFKRVL--MSSKYPDGVTGRIEFNEDGDRKFANYSIMNL--QNRKLV 383

  Fly   380 -VGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVR-RMGD---- 438
             ||.|:...:..      ||.:|||||.:..:|:|..:.|.|:::||.::|||||: .|.|
Frog   384 QVGIFNGSHVIQ------NDRKIIWPGGETERPQGYQMSTRLKIVTIHQEPFVYVKPTMTDGTCR 442

  Fly   439 DEFRCEPDERPCPLFNNSDAT-----ANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYI 498
            :|:....|.....:.|..:.|     ....||.|:||||||:|::.:||||::.|..||:||...
Frog   443 EEYTINGDPIKKVICNGPNETIPGRPTVPQCCYGFCIDLLIKLAREMNFTYEVHLVADGKFGTQE 507

  Fly   499 LRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSS 563
            ..||:.    :|||.|::|||::.:|||||||||||.|||:||||||||||||:|||.||....|
Frog   508 RVNNSN----KKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRS 568

  Fly   564 TLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGV 628
            ||.||:|||.:|||:||.:||||||::||||||||||||||: :|:..||.||.||||:||:|||
Frog   569 TLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKV-NSEEEEEDALTLSSAMWFSWGV 632

  Fly   629 LLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMEN 693
            |||||||||.|||||||:||||||||||||||||||||||||||:||:.:::||||.||||..:.
Frog   633 LLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDK 697

  Fly   694 LTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEASKD 758
            ...||||.||||:|||||||||.|||.||.:||.:|.:|||.|:..||.||||||:.||:|||:.
Frog   698 FIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQK 762

  Fly   759 CELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKT 823
            |:|||.||||.|||:|||::|.|||...|:|.||:.||:||||:|||.|:.:    |.|:.....
Frog   763 CDLVTTGELFFRSGFGIGMRKDSPWKQNVSLNILKSHENGFMEELDKTWVRY----QECDSRSNA 823

  Fly   824 PNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKRKTIR 888
            |.||..:||||||:||..||..|:.||.||:.||:|:..::|::.:|..|.:.||..::.||:.|
Frog   824 PATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGR 888

  Fly   889 A 889
            |
Frog   889 A 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	144/415 (35%)
		ANF_receptor	58..371	CDD:279440	117/334 (35%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	248/410 (60%)
		HisJ	451..>558	CDD:223904	59/111 (53%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	100/134 (75%)
		Lig_chan	575..838	CDD:278489	176/262 (67%)
		CaM_bdg_C0	854..882	CDD:287524	8/27 (30%)
grin1	XP_012825220.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	137/390 (35%)
		PBP2_iGluR_NMDA_Nr1	416..818	CDD:270437	248/410 (60%)
		Ion_trans_2	<620..675	CDD:369572	49/54 (91%)
		CaM_bdg_C0	854..882	CDD:371136	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	354	1.000	Domainoid score	I992
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7187
Inparanoid	1	1.050	771	1.000	Inparanoid score	I530
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D108757at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		oto103300
Panther	1	1.100	-	-	LDO	PTHR18966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.160