Protein Alignment Nmdar1 and grin1

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: XP_012825220.1
• Gene: grin1 / 780048
• XenbaseID: XB-GENE-494200
• Length: 941
• Species: Xenopus tropicalis
• Alignment Length: 911
• Identity: 427/911 - (46%)
• Similarity: 601/911 - (65%)
• Gaps: 60/911 - (6%)

  Fly    12 LFGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSEEHFSTTIKHLNFDQQYVPRKVTYYD 76
            ||.||::.|.:      ...|..:|...|||.|||....|:.|...:...|  :::...|:....
 Frog     6 LFLLAVLFLFS------FARAGCDPKIVNIGAVLSTKKHEQIFREAVNQAN--KRHGTWKIQLNA 62

  Fly    77 KTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGD-LSPAAVSYTSGFYSIPVIGISSRDAA 140
            .::....|.|:...:||:.||.::|||::|||.....| |:|..:|||:|||.|||||:::|.:.
 Frog    63 TSVTHRPNAIQMALSVCEDLISSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSI 127

  Fly   141 FSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQT--------TS 197
            :|||:||:|||||||||.|||.||.||:..|.:..||:|.|.|.:|||...:.:|        :.
 Frog   128 YSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEKESKSK 192

  Fly   198 QTYYDDVDVRA-------TVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAG 255
            :..|:::|..:       ..:.:::|||..::.|..|::.|..::||.::.||.:||..:::.|.
 Frog   193 KRNYENLDQLSYDNKRGPKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAA 257

  Fly   256 EYNMTGEGHVWIVTEQALFSN---NTPDGVLGLQLEHAHSDKGHIRDSVYVLASAIKEMISNETI 317
            ..:|||.|:||:|.|:.:..:   ..|||::||||.:..::..||.|:|.|.|.||.|:...|.|
 Frog   258 MLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESAHISDAVAVAAQAIHELFEMENI 322

  Fly   318 AEAPKDCGDSAVNWESG---KRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHV 379
            .:.|:.|..:...|::|   ||:.  :.|:...|.||::.|:::|||.:|.|.::|:  |.:|.|
 Frog   323 TDPPRGCVGNTNIWKTGPLFKRVL--MSSKYPDGVTGRIEFNEDGDRKFANYSIMNL--QNRKLV 383

  Fly   380 -VGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVR-RMGD---- 438
             ||.|:...:..      ||.:|||||.:..:|:|..:.|.|:::||.::|||||: .|.|
 Frog   384 QVGIFNGSHVIQ------NDRKIIWPGGETERPQGYQMSTRLKIVTIHQEPFVYVKPTMTDGTCR 442

  Fly   439 DEFRCEPDERPCPLFNNSDAT-----ANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYI 498
            :|:....|.....:.|..:.|     ....||.|:||||||:|::.:||||::.|..||:||...
 Frog   443 EEYTINGDPIKKVICNGPNETIPGRPTVPQCCYGFCIDLLIKLAREMNFTYEVHLVADGKFGTQE 507

  Fly   499 LRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSS 563
            ..||:.    :|||.|::|||::.:|||||||||||.|||:||||||||||||:|||.||....|
 Frog   508 RVNNSN----KKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRS 568

  Fly   564 TLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGV 628
            ||.||:|||.:|||:||.:||||||::||||||||||||||: :|:..||.||.||||:||:|||
 Frog   569 TLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKV-NSEEEEEDALTLSSAMWFSWGV 632

  Fly   629 LLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMEN 693
            |||||||||.|||||||:||||||||||||||||||||||||||:||:.:::||||.||||..:.
 Frog   633 LLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDK 697

  Fly   694 LTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEASKD 758
            ...||||.||||:|||||||||.|||.||.:||.:|.:|||.|:..||.||||||:.||:|||:.
 Frog   698 FIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQK 762

  Fly   759 CELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKT 823
            |:|||.||||.|||:|||::|.|||...|:|.||:.||:||||:|||.|:.:    |.|:.....
 Frog   763 CDLVTTGELFFRSGFGIGMRKDSPWKQNVSLNILKSHENGFMEELDKTWVRY----QECDSRSNA 823

  Fly   824 PNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKRKTIR 888
            |.||..:||||||:||..||..|:.||.||:.||:|:..::|::.:|..|.:.||..::.||:.|
 Frog   824 PATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGR 888

  Fly   889 A 889
            |
 Frog   889 A 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	137/390 (35%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	248/410 (60%)
		CaM_bdg_C0	854..882	CDD:402271	8/27 (30%)
grin1	XP_012825220.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	137/390 (35%)
		PBP2_iGluR_NMDA_Nr1	416..818	CDD:270437	248/410 (60%)
		CaM_bdg_C0	854..882	CDD:402271	8/27 (30%)