Protein Alignment Nmdar1 and grin1a

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: XP_073791110.1
• Gene: grin1a / 767745
• ZFINID: ZDB-GENE-051202-1
• Length: 966
• Species: Danio rerio
• Alignment Length: 935
• Identity: 434/935 - (46%)
• Similarity: 590/935 - (63%)
• Gaps: 79/935 - (8%)

  Fly    18 VLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSEEHFSTTIKHLNFDQQYVPRKVTYYDKTIRMD 82
            :||:|.:.:.........|...|||.|||....|:.|...:...|  |.|...|......::...
Zfish     3 LLLLAALFSCSCVRGGCEPKIVNIGAVLSQKRYEQVFKDAVTQAN--QVYGRDKFKLTAISVTHK 65

  Fly    83 KNPIKTVFNVCDKLIENRVYAVVVSHEQTSGD-LSPAAVSYTSGFYSIPVIGISSRDAAFSDKNI 146
            .|.|:...:||:.||.::|||::|||...|.| |:|..||||:|||.|||:|:::|.:.:|||:|
Zfish    66 ANAIQMALSVCEDLISSQVYAILVSHPPQSNDHLTPTPVSYTAGFYRIPVVGLTTRMSIYSDKSI 130

  Fly   147 HVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQT--------TSQTYYDD 203
            |:|||||||||.|||.||.:|:..|.:..:|:|.|.|.:|||...|.:|        ..:..|::
Zfish   131 HLSFLRTVPPYSHQAHVWFDMMREFRWNHIILIVSDDHEGRAAQKRLETLLEERETKNKKRNYEN 195

  Fly   204 VDVRA-------TVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTG 261
            .|..:       ..|.:::|..: .:.|..|::.|..::||.::.||.|||..:::.|...||||
Zfish   196 QDQLSYDNKRGPKAEKVLQFNQE-TNLTALLLEAKELEARVIILSASEEDAAAVYKTARFLNMTG 259

  Fly   262 EGHVWIVTEQALFS---NNTPDGVLGLQLEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKD 323
            .|:||:|.|:.:..   :..|||::||||.:..::..||.|:|.|:|.:|:|:...|.|.|.|:.
Zfish   260 SGYVWLVGEREMSGKALSEAPDGLIGLQLINGKNESAHISDAVAVVAQSIQELFEKENITEPPRG 324

  Fly   324 CGDSAVNWESG---KRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHVVGKFSY 385
            |..:...|::|   ||:.  :.|:...|.||:|.|:|:|||.||.|.::|   .||..::....|
Zfish   325 CVGNTNIWKTGPLFKRVL--MSSKYPEGLTGRVEFNDDGDRKYAHYSILN---YQKSRLIQVGIY 384

  Fly   386 DSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERP- 449
            :..:..|.   ...:|||||.:..:|.|..:.|.|:::||.::|||||:.. ..|..|:.:..|
Zfish   385 NGTQVVMN---KQRKIIWPGGETERPRGFQMSTRLKIVTIHQEPFVYVKPT-TLEGTCKEEYTPN 445

  Fly   450 --------CPLFNNSDATANEF---------CCRGYCIDLLIELSKRINFTYDLALSPDGQFGHY 497
                    |       ...||.         ||.|:||||||:|:..:||||::.|..||:||..
Zfish   446 GVLIKKVIC-------TGPNETIPGRPIVPQCCYGFCIDLLIKLALTMNFTYEVHLVADGKFGTQ 503

  Fly   498 ILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRS 562
            ...||:.    :|||.|::|||:...|||||||||||.|||:||||||||||||:|||.||....
Zfish   504 ERVNNSN----KKEWNGMMGELLGGLADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPR 564

  Fly   563 STLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWG 627
            |||.||:|||.:|||:||.:||||||::||||||||||||||: :|:..||.||.||||:||:||
Zfish   565 STLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKV-NSEEEEEDALTLSSAMWFSWG 628

  Fly   628 VLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTME 692
            ||||||||||.|||||||:||||||||||||||||||||||||||:||:.:::||||.||||..:
Zfish   629 VLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSD 693

  Fly   693 NLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEASK 757
            ....||||.||||:|||||||||.|||.||.:||.:|.:|||.|:..||.||||||:.||:|||:
Zfish   694 KFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQ 758

  Fly   758 DCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEK 822
            .|:|||.||||.|||:|||::|.|||...|:||||..||:||||.|||.|:.:    |.|:....
Zfish   759 KCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLAILSSHENGFMEDLDKTWVRY----QECDSRSN 819

  Fly   823 TPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKRKTI 887
            .|.||..:||||||:||..|||.|:.||.||:.||:|:..::|::.:|..|.:.||..::..|..
Zfish   820 APATLTFENMAGVFMLVAGGIAAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDNKES 884

  Fly   888 RASLAMQRQYNVGLNSTHAPGTISL 912
            ..|.|      ||     |.||.||
Zfish   885 SGSQA------VG-----AAGTPSL 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	139/389 (36%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	249/418 (60%)
		CaM_bdg_C0	854..882	CDD:402271	8/27 (30%)
grin1a	XP_073791110.1	None