DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and grin2aa

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	XP_021329529.1	Gene:	grin2aa / 563297	ZFINID:	ZDB-GENE-070424-129	Length:	1460	Species:	Danio rerio

Alignment Length:	1029	Identity:	267/1029 - (25%)
Similarity:	465/1029 - (45%)	Gaps:	169/1029 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 DKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGI-SSRDAAFSDKN 145
            :.:|...:.:|||.:...:::.||.. :.|..:.....:.:.|....||::|| .......:||:
Zfish    73 ETDPKSIITHVCDLMSGTKIHGVVFG-DGTDQEAIAQILDFISSQTLIPILGIHGGSSMIMADKD 136

  Fly   146 IHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATV 210
            :..:|.:.......:|.:.|.::..:.:....|:.|.....:..:...:||....:...|::..:
Zfish   137 VKSTFFQFGASIQQEALLMLNIMEEYDWHVFSIVTSKFPGYQDFIAILKTTVDNSFVGWDLQHII 201

  Fly   211 EL-IVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALF 274
            .| .|:.:.:.:      |.:|..||.|.|:|.|.::|..|..:|....:||.|::|||  .:|.
Zfish   202 TLDAVDGDSRTQ------IQLKKVQSPVVLLYCSKDEAAYILEEARSLGLTGFGYIWIV--PSLT 258

  Fly   275 SNN---TPDGVLGLQLEHAHSD-----KGHIRDSVYVLASAIKEMISN-ETIAEAPKDC-GDSAV 329
            :.|   |||......:..::.|     :..:||.:.::.:|...|:.. ..|.||...| |....
Zfish   259 TGNPEITPDTFPSGMISVSYDDWDYPLEARVRDGLGIITTAAAAMLEEFGDIPEAKTSCYGQMEK 323

  Fly   330 NWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHVVGKFSYDSMRAKMRM 394
            .......|.:|:  .|:|.:...::|.::|.:::....||.:.:.::...:||:...|:..|..
Zfish   324 TKLPPSALHKYM--MNVTWDGKDLSFTEDGYQVHPKLVVIVLNKDREWEKMGKWENQSLTLKYP- 385

  Fly   395 RINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDAT 459
                   :|| :.....:......||.::|:||||||.|..:......|..:..||......:.|
Zfish   386 -------VWP-RFNSFGDAETDDNHLTIVTLEEKPFVIVENVERLTGTCMRNSVPCRKHIKDNTT 442

  Fly   460 AN-----EFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGEL 519
            ..     :.||:|:|||:|.::::.:.|||||.|..:|:.|..|  ||.        |.|::||:
Zfish   443 EGGGTYIKKCCKGFCIDILKKIARNVKFTYDLYLVTNGKHGKKI--NNV--------WNGMVGEV 497

  Fly   520 VNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVS---FLQPFSNTLWILVM 581
            ||::|.|.|..||||.||:|.|:||.||...||:::   .|||:..||   ||:|||.::|:::.
Zfish   498 VNKKAVMAVGSLTINEERSEVIDFSVPFVETGISVM---VSRSNGTVSPSAFLEPFSASVWVMMF 559

  Fly   582 VSVHVV-ALVLYLLDRFSPFG-RFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSA 644
            |.:.:| |:.:::.:..||.| ...|:........:..:..|||..||::.|:.:....|:..::
Zfish   560 VMLLLVTAMAVFMFEYISPLGFNRNLAQGKDPHGPSFTMGKAVWLLWGLVFNNSVPVQNPKGTTS 624

  Fly   645 RVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTME---NLTCATVKGSSVDM 706
            :.:..|||.||:|.:||||||||||::.|....:::|::|.:.::...   .....||...|.:.
Zfish   625 KFIVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQSPYSYSPPFRFGTVPNGSTER 689

  Fly   707 YFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEASKD--CELVT--AGEL 767
            ..|:  ...:|::.|...:......|:..:|.|||.|||:|::.|.|.|.:|  |:|||  :|.:
Zfish   690 NIRK--NYPDMHQYMVKYHQTGVNDALVSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGYI 752

  Fly   768 FGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHG--HVQQNCELFEKTPNTLGLK 830
            |..:||||.|||||.|...|.||||.....|.||:|:.||: .|  |.::|    |...:.|.:.
Zfish   753 FATTGYGIALQKGSLWKRPVDLAILAIIGDGEMEELEAQWL-TGICHNEKN----EVMSSQLDVD 812

  Fly   831 NMAGVFILVGVGIAGGVGLIIIEVIYKK--------------------------------HQV-- 861
            ||||||.:    :|..:||.:|..:::.                                |.|
Zfish   813 NMAGVFYM----LATAMGLSLITFVWEHLFYWRLRYCFTGVCSGTPGLLFSISRGIWSCIHGVHI 873

  Fly   862 ---KKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVG---LNS---------THAPGTIS 911
               ||...||.:..:        ...|.|:::..|....|:.   :||         :.:|..:.
Zfish   874 DMKKKSSDLDFSPQS--------NMLKLIKSAKQMTNMTNLSGSRINSPKRGGEFMHSASPMIMD 930

  Fly   912 LAVDKRRYPRLGQRLGPERAWPGDAADV---LRIRRPYELGN---PGQSPKVMAANQP------- 963
            :..:|..:.....|...::...||::|:   |..|....|.|   .||.|..:..:.|
Zfish   931 MMAEKGNFIYTDNRSYAQKDIYGDSSDLQSYLTNRHKDHLNNYIFQGQHPLTLNESNPNTVEVAV 995

  Fly   964 --------GMPMPMLGKT--------------RPQQSVLPPRYSPGYT--SDVS 993
                    ..|..:..|:              .|:.|:...||.|..|  ||:|
Zfish   996 SADTAQTNAKPRALWKKSVDTLRQTPQGPETLDPRLSMKSQRYLPEDTAHSDIS 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	69/334 (21%)
		ANF_receptor	58..371	CDD:279440	64/300 (21%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	148/419 (35%)
		HisJ	451..>558	CDD:223904	42/111 (38%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	46/139 (33%)
		Lig_chan	575..838	CDD:278489	91/273 (33%)
		CaM_bdg_C0	854..882	CDD:287524	6/64 (9%)
grin2aa	XP_021329529.1	PBP1_iGluR_NMDA_NR2	33..389	CDD:107373	70/335 (21%)
		PBP2_iGluR_NMDA_Nr2	400..799	CDD:270436	146/414 (35%)
		NMDAR2_C	836..1460	CDD:313729	37/222 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910