Protein Alignment Nmdar1 and grid1b

DIOPT Version :9

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: XP_009304811.1
• Gene: grid1b / 557511
• ZFINID: ZDB-GENE-121214-84
• Length: 1048
• Species: Danio rerio
• Alignment Length: 1105
• Identity: 266/1105 - (24%)
• Similarity: 439/1105 - (39%)
• Gaps: 249/1105 - (22%)

  Fly    37 STYNIGGVLSNSDS--EEHFSTTIKHLNFDQQYV-PRKVTYYDKTIRMDKNPIKTVFNVCDKLIE 98
            |..:||.:...:.:  :|.|...|..|:.:...: ..|:|:..|.|. ..||.:.|...|: |:.
Zfish    22 SIIHIGAIFEENAARDDEVFQLAISDLSLNDDILQSEKITHSIKYIE-PNNPFQAVQEACE-LMT 84

  Fly    99 NRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDK---NIHVS-----FLRTVP 155
            ..:.|:|.|    :|..|.:|:...:....||.:.: .|:|..|.:   .::.|     :.....
Zfish    85 QGILALVTS----TGCASASALQSLTDAMHIPHLYV-QRNAEGSPRTACQLNPSPDGERYTLAAR 144

  Fly   156 PYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKL 220
            |.....||.|.::....:.|.|:.:.||.|.|.:......||:...|....|....:...|....
Zfish   145 PPVRLGDVMLTLVGELRWQKFIVFYDSDYDIRGLQVFLDQTSRQGLDVSLQRVDRNISGVFSSLF 209

  Fly   221 ESF-TEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFSNNTPDGVLG 284
            .|. ||.|...:....|..|: .|...|||....|.|.|:..:...|:...:.:.....
Zfish   210 TSMRTEELNRYRDTLRRAILL-LSPRGAQVFIHQAVETNLASKDSHWVFVNEEISDTEI------ 267

  Fly   285 LQLEHAHSDKG----------------------------------------------HIRDSVYV 303
              ||.|||..|                                              ::.|||.:
Zfish   268 --LELAHSSLGRMTVVRQIFPLWRDSSVSCMRNSHRISSLLCDPQEGYLQSLEVSNLYLYDSVLM 330

  Fly   304 LASAI-KEMISNETIAEAPKDC-GDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGY 366
            ||:|. :::...:..:.|..:| ..|...|..|..:.:.::...|||.||.:.|.:||...:..:
Zfish   331 LANAFYRKLEDRKWHSMASLNCIRKSTKPWNGGWSMLETIQKGRITGLTGIMDFMENGSNSHVQF 395

  Fly   367 DVI--NIREQQKKHVVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKP 429
            :::  :..|...|.:....::||:..     :|.|.     |:.|...|:...| ::::|:.|.|
Zfish   396 EILGTSFSETFGKDIKRLATWDSVHG-----LNGSL-----KESRIENGMQGVT-VKVVTLLEDP 449

  Fly   430 FVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQF 494
            ||.|.    :....:|..                 .:|:.||:|..|:|.:.|.||:....|.::
Zfish   450 FVMVA----ENILGQPKR-----------------YKGFSIDVLEALAKILGFKYDIYQVADSKY 493

  Fly   495 GHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKP 559
            |..:...:         |.|:||||:|:|||:.|:.:||.|||...::|||.:....:.||.:||
Zfish   494 GSQLSNGS---------WNGMIGELINKRADLAVSAITITPERENVVDFSKRYMDYSVGILHRKP 549

  Fly   560 SRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRF------SPFGRFKLSHSDSNEEKALNL 618
            .....:.|...||...:|..:..::.||.::::||.|.      :|.|....| |.||     :|
Zfish   550 EEKINIFSLFAPFDLAVWACIAAAIPVVGVLIFLLTRMQMLRSQNPPGAHHAS-SMSN-----SL 608

  Fly   619 SSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGIN 683
            .||:|..:|..:..| |:....|.:.|::...|..|.:|:.:||||||||||.:.|....:....
Zfish   609 HSAIWIVYGAFVQQG-GDSVVGSVALRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNTIRTFQ 672

  Fly   684 DARLRNTMENLTCATVKGSSVDMYFR--------RQVELSNMYRTMEANN-----YATAEQAIQD 735
            |  |...|: ....||:.|:|..||:        :....:.::||:..||     .::..:.|:.
Zfish   673 D--LARQMD-FAYGTVRDSAVYDYFKAKGTNPLEQDSTYAELWRTISKNNGQDFSVSSPSEGIRK 734

  Fly   736 VKKGKLMAFIWDSSRLEYEA--SKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESG 798
            .|||. .||:||.:.:||.|  ..||.:..:|......||||.:|.|||:.|.::..|||..|.|
Zfish   735 AKKGP-YAFLWDMAVVEYAALTDDDCTITVSGNSMSSKGYGIAMQHGSPYRDLISQKILELQEKG 798

  Fly   799 FMEKLDKQW---------IFHGHVQQNCELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEV 854
            .::.|.::|         ..|.:.|.:       ..:|.|.:.||||.::..|:.....:..:|:
Zfish   799 DLDVLKQKWWPRTGRCDLNSHSNAQPD-------GRSLKLHSFAGVFCILAAGLLLACLVAALEM 856

  Fly   855 IYKKH--------QVKKQKRL----------DIARHAA----DKWRGTIEKRKTIRA-------- 889
            .:..:        :|.|..||          |||..::    |.|  |..:|....|
Zfish   857 WWNSNRCRQEQPKEVTKDYRLARVSGPLTYNDIATASSEGSKDIW--TDRERDWDEAEAIDTGQG 919

  Fly   890 ------SLAMQRQYNVGLNSTHAPGTI--SLAVDKRRY---PRLG--QRL---GP--------ER 930
                  :.|.::.|..|..:...|.||  .|....|::   |..|  .||   ||        ..
Zfish   920 GEPGTGASAFEQPYGRGHGTQADPRTIYRDLCPGHRQHAAQPAAGGCARLPGHGPVCEHLPPGAS 984

  Fly   931 AWPGDAADVLRIRRPYELGNPGQ----SPKVMAANQPGMPMPMLGKTR---PQQS-------VLP 981
            :|.|...|            ||.    :|.....:.|..||...|..|   |.:|       |||
Zfish   985 SWGGSDTD------------PGSWQHPAPSSQQLHHPLHPMQTQGSQRGPVPTESRQDTHANVLP 1037

  Fly   982  981
            Zfish  1038  1037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	88/429 (21%)
		ANF_receptor	58..371	CDD:279440	77/372 (21%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	125/430 (29%)
		HisJ	451..>558	CDD:223904	32/106 (30%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	45/140 (32%)
		Lig_chan	575..838	CDD:278489	86/292 (29%)
		CaM_bdg_C0	854..882	CDD:287524	10/49 (20%)
grid1b	XP_009304811.1	PBP1_iGluR_delta_1	25..424	CDD:107387	85/419 (20%)
		ANF_receptor	36..400	CDD:279440	79/379 (21%)
		Periplasmic_Binding_Protein_Type_2	437..809	CDD:304360	123/413 (30%)
		Lig_chan	565..840	CDD:278489	86/292 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910