Protein Alignment Nmdar1 and grid2

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: NP_001004123.1
• Gene: grid2 / 448841
• ZFINID: ZDB-GENE-040913-1
• Length: 1009
• Species: Danio rerio
• Alignment Length: 940
• Identity: 226/940 - (24%)
• Similarity: 390/940 - (41%)
• Gaps: 197/940 - (20%)

  Fly    37 STYNIGGVLSNS--DSEEHFSTTIKHLNFDQQYV-PRKVT----YYDKTIRMDKNPIKTVFNVCD 94
            |..:||.:...|  ..:|.|...:..||.:.:.: ..|:|    :.|     ..||.:.|...|:
Zfish    25 SIIHIGAIFDESAKKDDEVFRMAVADLNLNNEILETEKITVSVEFVD-----GNNPFQAVQEACE 84

  Fly    95 KLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAF----------SDKNIHVS 149
              :.||....:||   :.|.:|..::...:....||.:.|....|..          :..:.:..
Zfish    85 --LMNRGILALVS---SIGCMSAGSLQSLADAMHIPHLFIQRAPAGTPRSSCPPTTRAQPDDYTL 144

  Fly   150 FLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIV 214
            |:|  ||.|.. ||..:::..:.:.|.||.:.:|.|.|.|......|||...|       |.|
Zfish   145 FVR--PPVYLN-DVIFQVVMEYTWQKFIIFYDTDYDIRGIENFLDQTSQQGMD-------VSL-- 197

  Fly   215 EFEPKLESFTEHLI-----DMKTAQSRVY-------LMYASTEDAQVIFRDAGEYNMTGEGHVWI 267
               .|:||....:|     .|:..:...|       :::.|...|:....:..|.|:......||
Zfish   198 ---QKVESNINMMITGMFRTMRVEELHRYRDTLRRAVLFMSPATAKAFITEVVETNLVAFDCQWI 259

  Fly   268 V---------------------------------TEQALFSNN--------TPDGVLGLQLEHAH 291
            :                                 |.|....||        .|.......||..:
Zfish   260 IINEEISDMDVQELVMKSIGRLTLVRQTFPLPQNTSQRCVRNNHRINTSLCDPKDPKAQMLEITN 324

  Fly   292 SDKGHIRDSVYVLASAI---------KEMISNETIAEAPKDCGDSAVNWESGKRLFQYLKSRNIT 347
            .   :|.|:|.:||:..         ..|.|...|.:..|.       |:.||.:.:.:|...::
Zfish   325 R---YIYDTVLLLANTFHRKLEDRKWHSMASLSCIRKGSKP-------WQGGKSMLETVKKGGVS 379

  Fly   348 GETGQVAFDDNGDRIYAGYDVI--NIREQQKKHVVGKFSYDSMRAKMRMRINDSEIIWPGKQRRK 410
            |.|..:.|:|||......::::  |..|.:.:.|....::|.:.. :...:.|          ||
Zfish   380 GLTSLLEFNDNGSNPNIHFEILGTNYGEDRGRGVSRLATWDPIHG-LNGTLTD----------RK 433

  Fly   411 PEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIE 475
            .|..|....||::|:.|:|||.|    .:....:|.:                 .:|:.||:|..
Zfish   434 LENNMRGVVLRVVTVLEEPFVMV----SENVLGKPKK-----------------YQGFSIDVLDA 477

  Fly   476 LSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEY 540
            |:..:.|.|::.::||.::         |:......|.|||||||.:|||:.::.|||.|||...
Zfish   478 LANYLGFKYEIYVAPDHKY---------GSQQADGTWNGLIGELVFKRADVGLSALTITPERESV 533

  Fly   541 IEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKL 605
            ::|:..:....:.:|.:|..|:..:.:.|.||..:||..:..:|.:|..::|||:..:| .|..:
Zfish   534 VDFTTRYMDYSVGVLLRKAERTVDMFACLAPFDLSLWACIAGTVLLVGTLVYLLNWLNP-PRLPM 597

  Fly   606 SHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFL 670
            ....|.     .|.:::||.:|..:..| ||....:.:.|::..||..||:|:::||||||||||
Zfish   598 GSVSST-----TLYNSMWFVYGSFVQQG-GEVPYTTLATRMMMGVWWLFALIVISSYTANLAAFL 656

  Fly   671 VLERPKTKLSGINDARLRNTMENLTCATVKGSSV-DMY-------FRRQVELSNMYRTME----- 722
            .:.|.:..:..:.|...:.   :|...||..|:| |..       |.|....|.|:|.:.
Zfish   657 TISRIENSIQSLQDLAKQT---DLPYGTVLDSAVYDQVRSKGMNPFERDPMYSQMWRMINRTGGA 718

  Fly   723 ANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEA--SKDCELVTAGELFGRSGYGIGLQKGSPWTD 785
            .||...:::.|:.||.|: .||:||::.|||.|  .:||.|.|........|||:.:|.|||:.|
Zfish   719 ENNVEESKEGIRKVKYGR-FAFVWDAAVLEYVAINDEDCSLYTVSNNVADRGYGMAMQHGSPYRD 782

  Fly   786 AVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELF-----EKTPNTLGLKNMAGVFILVGVGIAG 845
            ..:..|||..::|.|:.|..:|   ......|:|:     .|:.:.|.:.:.||||.::..|:..
Zfish   783 IFSQRILELQQNGDMDILKLKW---WPRDSPCDLYSPVGTRKSGSALDIHSFAGVFFVLAAGVVL 844

  Fly   846 GVGLIIIEVIYKKHQVKK------QKRLDI 869
            ...:..:|..:.:.:..:      .|.:|:
Zfish   845 SCLIATVETWWTRRKGSRVPSKEDDKEIDL 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	88/448 (20%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	122/415 (29%)
		CaM_bdg_C0	854..882	CDD:402271	2/22 (9%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..429	CDD:380614	86/436 (20%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	122/409 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	989..1009