DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and GluRIID

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster

Alignment Length:	980	Identity:	225/980 - (22%)
Similarity:	417/980 - (42%)	Gaps:	192/980 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IVLLVAPIDA----AQRHTASDNPSTYNIGGVLSNSDSEEHFSTTIKH----LNFDQQYVP---- 69
            |:|.::.:.|    ...:.||...| ..:|  |...|:.:....|.:|    :| ::..||
  Fly     9 IILSLSRVQAQFYGGNAYEASSGQS-IRLG--LITDDATDRIRQTFEHAISVVN-NELGVPLVGE 69

  Fly    70 -RKVTYYDKTIRMDKNPIKTVFNVCDKLIENRVYAV-------VVSHEQTSGDLSPAAVSYTSGF 126
             .:|.|        .|.::....:| :|:::.|.||       ..||...:.|.......|
  Fly    70 TEQVAY--------GNSVQAFAQLC-RLMQSGVGAVFGPAARHTASHLLNACDSKDIPFIY---- 121

  Fly   127 YSIPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILG 191
               |.:...|....|   |:|       |.....|:...::::.|.:::.|..:.| .:...||.
  Fly   122 ---PHLSWGSNPDGF---NLH-------PSPEDIANALYDIVNQFEWSRFIFCYES-AEYLKILD 172

  Fly   192 RFQTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLID--MKTAQSRVYLMYASTEDAQVIFRDA 254
            ...|.       ..::..|..::.::..|....:.::.  .|:..||:.::.::|..|::: |.|
  Fly   173 HLMTR-------YGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGSTTGVAELL-RQA 229

  Fly   255 GEYNMTGEGHVWIVTEQALFSNNTPD------GVLGLQLEHAHSDKGHIRDSVYVLASAIKE--- 310
            .:..:..|.:.:|:....|.:.:..:      .:.|:::  ...|:..:||.:..|...:.|
  Fly   230 QQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRM--FSPDQEEVRDLMEKLHQELGESEP 292

  Fly   311 ------MISNE---------TIAEAPK---------DCGDSAVNWE-SGKRLFQYLKSRNITGE- 349
                  .|:.|         .|||..|         :|.:...|.: .|.....|::|..|..:
  Fly   293 VNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPDGSTFRNYMRSLEIKEKT 357

  Fly   350 -TGQVAFDDNGDRIYAGYDVINIREQQKKHVV-------GKFSYDSMRAKMRMRINDSEIIWPGK 406
             ||::.|:.|..:.:. :|||   |.|...:|       || .::..|....:..||.:
  Fly   358 ITGRIYFEGNVRKGFT-FDVI---ELQTSGLVKVGTWEEGK-DFEFQRPPQAVNFNDID------ 411

  Fly   407 QRRKPEGIMI-PTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCI 470
                 :|.:: .|.:.|:::..||:..:....|            .|..|     |:|  :||.:
  Fly   412 -----DGSLVNKTFIVLISVATKPYASLVESID------------TLIGN-----NQF--QGYGV 452

  Fly   471 DLLIELSKRINFTYDLALSPDG--QFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTI 533
            ||:.||:.::.|.:...   ||  .:|.:   |.|...|     :|::.|:|..|||:.:..|||
  Fly   453 DLIKELADKLGFNFTFR---DGGNDYGSF---NKTTNST-----SGMLKEIVEGRADLAITDLTI 506

  Fly   534 NPERAEYIEFSKPFKYQGITILEKKPSRS-STLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRF 597
            ..||.|.|:||.||...||.||..||.:: ..|.||:.|||:.:|:.:.::...|:|..:::.|.
  Fly   507 TSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRL 571

  Fly   598 SPF---GRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIV 659
            ||.   ..:.........|....:::::||..|.||..| .|..|::.|.|.:..:|..|.:|:|
  Fly   572 SPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQG-SEIAPKALSTRTISAIWWFFTLIMV 635

  Fly   660 ASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFRRQVELSNMYRTMEAN 724
            :||||||||||.:|.|.:.::.:.|  |.:..:::.....:..|...:|....|  .:|  ::.|
  Fly   636 SSYTANLAAFLTIENPTSPINSVKD--LADNKDDVQYGAKRTGSTRNFFSTSEE--PIY--IKMN 694

  Fly   725 NYATA---------EQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYGIGLQKG 780
            .|..|         :|.:..||.|...||:.:|:.:|:...::|.|...|:.....||||.:.|.
  Fly   695 EYLNAHPEMLMENNQQGVDKVKSGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKN 759

  Fly   781 SPWTDAVTLAILEFHESGFMEKLDKQW---IFHGHVQQNCELFEKTPNTLGLKNMAGVFILVGVG 842
            .|:.|....|:||..|.|.:.:|..:|   :..|......:  :..|:.||:.|::|:::::
  Fly   760 WPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSD--DDGPSELGVDNLSGIYVVL--- 819

  Fly   843 IAGGVGLIIIEV------IYKKHQVKKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGL 901
            :.|.:..|||.:      :|||   .|...:......|:::|..|...:..|...:.|..|:...
  Fly   820 VIGSIISIIISILCWCYFVYKK---AKNYEVPFCDALAEEFRIVIRFSENERPLKSAQSIYSRSR 881

  Fly   902 NSTHA 906
            ||:.:
  Fly   882 NSSQS 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	84/452 (19%)
		ANF_receptor	58..371	CDD:279440	66/366 (18%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	119/418 (28%)
		HisJ	451..>558	CDD:223904	38/108 (35%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	45/138 (33%)
		Lig_chan	575..838	CDD:278489	73/277 (26%)
		CaM_bdg_C0	854..882	CDD:287524	6/33 (18%)
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	75/406 (18%)
		ANF_receptor	46..380	CDD:279440	68/375 (18%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	118/407 (29%)
		Lig_chan	549..819	CDD:278489	73/278 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462864
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.940