DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar1 and Ir75c

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster

Alignment Length:	675	Identity:	119/675 - (17%)
Similarity:	250/675 - (37%)	Gaps:	161/675 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 HVWIVTE----------QALFSN----NTPDGVLGLQLEHAHSDKGHIRDSVYV-LASAIKEMIS 313
            |.|.:.|          ..:||.    ..||.:..:..|:..||.  :|..|:: |.....|:::
  Fly    26 HCWSIKEAFPLVEMLNQNGIFSQYIDVQNPDNLANVHKEYLDSDL--VRLGVFLDLGCDKAELVT 88

  Fly   314 NETIAEAPKDCGDSAVNW----ESGK--RLFQYLKSRNIT--GETGQVAFDDNGDRIYAGYDVIN 370
            |::   :.....:..::|    |:|.  :|.|..:..|::  .:...|:.:|  :..:..:||.|
  Fly    89 NQS---SRARLYNQNLHWLLYDEAGNFTKLTQLFEGANLSLNADVTYVSRED--EERFILHDVYN 148

  Fly   371 IREQQKKHVVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRR 435
                :..|:.||           :.|...:.:...:...:.:..:...|||       |.:..|.
  Fly   149 ----KGSHLGGK-----------LNITVDQTLQCNRSHCQVKEYLSELHLR-------PRLQHRM 191

  Fly   436 -MGDDEFRCEPDERPCPLFNNSDATANEF--CCRGYCIDLLIELSKR-INFTYDLALSPDGQFGH 496
             :....||........|: |:|:....||  ..|...:|.:..:..| |..|.::.    |...|
  Fly   192 DLSSVTFRLAALVSVLPI-NSSEEELLEFLNSDRDSHMDSISRIGNRLIMHTQEIL----GFKLH 251

  Fly   497 YILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIE-FSKPFKYQGITILEKKPS 560
            ||.   .|..:::..:.|.||.|.||.|::...|...:..|..|:. .::..:::.:.:.....:
  Fly   252 YIW---CGTWSVQDAFGGAIGMLTNESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHN 313

  Fly   561 RSSTLVSFLQPFSNTLWIL---VMVSVHVVALVLYLLDR--------FSPFGRFKLSHSDSNEEK 614
            .......||:||..::|..   :::...|:..:::.|:|        |.|
  Fly   314 AGIKAAVFLEPFMPSVWFAFAGLLIFAGVLLWMIFHLERHWMQRCLDFIP--------------- 363

  Fly   615 ALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKL 679
              :|.|:...::|.....| ....|:|...| |..:.......::.:|..::....:|..|
  Fly   364 --SLLSSCLISFGAACIQG-SYLMPKSAGGR-LAFIAVMLTSFLMYNYYTSIVVSTLLGSP---- 420

  Fly   680 SGINDARLRNTMENLTCATVKGSSVDMYF------------RRQVELSNMYR-----TMEANN-Y 726
                   :|:.:.  |...:..||:|:.|            ..:.::.::|:     ..:.|: :
  Fly   421 -------VRSNIR--TIQQLADSSLDVGFDTVPFTKTYLVSSPRPDIRSLYKQKVESKRDPNSVW 476

  Fly   727 ATAEQAIQDVK---------KGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYGIGLQKGSP 782
            .:.|:.:..|:         :...|....:...|..|.|...|::...|   .:.||: :...|.
  Fly   477 LSPEEGVIRVRDQPGFVYTSEASFMYHFVEKHYLPREISDLNEIILRPE---SAVYGM-VHLNST 537

  Fly   783 WTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKT-----PNT----LGLKNMAGVFIL 838
            :...:|...:...|:|...|..:             .|.||     .|:    :|::..|.:||.
  Fly   538 YRQLLTQLQVRMLETGITSKQSR-------------FFSKTKLHTFSNSFVIQVGMEYAAPLFIS 589

  Fly   839 VGVGIAGGVGLIIIEVIYKKHQVKK 863
            :.|.....:.::|:|:.:.::..||
  Fly   590 LLVAYFLALLILILEICWARYAKKK 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	30/163 (18%)
		ANF_receptor	58..371	CDD:279440	25/129 (19%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	76/443 (17%)
		HisJ	451..>558	CDD:223904	25/110 (23%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	27/146 (18%)
		Lig_chan	575..838	CDD:278489	47/309 (15%)
		CaM_bdg_C0	854..882	CDD:287524	2/10 (20%)
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	38/260 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462792
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940