DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and clumsy

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster

Alignment Length:	973	Identity:	230/973 - (23%)
Similarity:	409/973 - (42%)	Gaps:	218/973 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LFGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSN--SDSEEHFSTTIKHLNF---DQQYVPRK 71
            ||....:|:..|:      .|..:.|.:.:|.:.::  .:||..|.|.:...|.   :.:.||
  Fly     4 LFLTHFLLIALPV------LADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVP-- 60

  Fly    72 VTYY---DKTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGF----YS- 128
            :..|   |.:..|:|       .||: ||...|.|:......:|.|:. |::..|...    |.
  Fly    61 IVVYANTDDSFIMEK-------MVCN-LISQGVIAIFGPSTGSSSDII-ASICDTLDIPHIVYDW 116

  Fly   129 IPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRF 193
            ||...|..|:.:....|:|       |.....:....|::..||:....:::.:|.:    |.:.
  Fly   117 IPNESIPDREHSTMTLNVH-------PDNLLLSQGLAEIVQSFAWRSFTVVYETDKE----LQQL 170

  Fly   194 QTTSQTYYDDVDVRATVELIVEFEPKLESFTEH---LIDMKTAQSRVYLMYASTEDAQVIFRDAG 255
            |...|. .:.:....||:       :|....:|   |.::|.:.....:::.:.::...|.:.|.
  Fly   171 QDILQV-GEPISNPTTVK-------QLGPGDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQAN 227

  Fly   256 EYNMTGEGHVWIVTEQALF-----SNNTPDGVL-GLQL----------------------EHAHS 292
            |..|.||       .|::|     :::...|.| |::.                      |....
  Fly   228 ELKMLGE-------YQSVFIPLLDTHSIDFGELSGVEANITTVRLMDPSDFHVKNVVHDWEEREK 285

  Fly   293 DKGH---------------IRDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESGKRLFQYLK 342
            .:|.               :.|:|::.:..:.|:...|.:.....:|.... .|..|||:.:::|
  Fly   286 REGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTAPDLECRRKK-PWPFGKRIIEFIK 349

  Fly   343 SRNITGETGQVAFDDNGDRIY----------------------AGYDVINIREQQKKHVVGKFSY 385
            :|:....||::.|::||.|.:                      .|.||:|..|:.:|.|..|.|.
  Fly   350 ARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDEESEKRVGQKLSN 414

  Fly   386 DSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPC 450
            .:.....|:                                ..||:.:|         ||.|...
  Fly   415 KTFIVSSRL--------------------------------GAPFLTLR---------EPQEGEI 438

  Fly   451 PLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGL 515
             |..||.       ..||.|||:.|::|.:||.::..:||||::|        ....:.:.|.|:
  Fly   439 -LTGNSR-------YEGYSIDLINEIAKMLNFKFEFRMSPDGKYG--------ALNKVTQTWDGI 487

  Fly   516 IGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSST-LVSFLQPFSNTLWIL 579
            :.:|::..||:.:..||:...|.:.::|:.||...||:||..||....| |.|||.|||..:||.
  Fly   488 VRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIY 552

  Fly   580 VMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSS---AVWFAWGVLLNSGIGEGTPRS 641
            :..:...::|:|:.|.|.:| ..::..|.....|:..|:.|   ..|.:.|.|:..|. :..|::
  Fly   553 MGSAYLFISLLLFALARMAP-DDWENPHPCKEPEEVENIWSIMNTTWLSIGSLMGQGC-DILPKA 615

  Fly   642 FSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDM 706
            .|.|::..:|..||::::.||||||||||...|   :.:.||.|........:....:.|.|...
  Fly   616 ASTRLVTGMWWFFALMMLNSYTANLAAFLTNSR---QANSINSAEDLAAQSKIKYGAMAGGSTMG 677

  Fly   707 YFRRQVELSN------MYRTMEANNYA----TAEQAIQDVKKGK-LMAFIWDSSRLEYEASKDCE 760
            :||.    ||      |:..||:.:.:    |.::.::.|:||| |.||:.:|:.|||...:.|:
  Fly   678 FFRD----SNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCD 738

  Fly   761 LVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEK--- 822
            ||..|.......|||.:...||:...::.|:|:..|.|.:.:|.::|....|...|||..::
  Fly   739 LVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGG 803

  Fly   823 -TPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDI-------ARHAADKW 877
             ||. |||:|:.|||:::|:|:...:.|...|.::....|..::::.:       |..||..|
  Fly   804 DTPE-LGLENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIW 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	89/473 (19%)
		ANF_receptor	58..371	CDD:279440	71/391 (18%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	121/415 (29%)
		HisJ	451..>558	CDD:223904	32/106 (30%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	41/138 (30%)
		Lig_chan	575..838	CDD:278489	84/280 (30%)
		CaM_bdg_C0	854..882	CDD:287524	5/31 (16%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	74/407 (18%)
		ANF_receptor	39..379	CDD:279440	71/377 (19%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	120/438 (27%)
		Lig_chan	548..812	CDD:278489	80/273 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462675
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.990