DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and GluRIIE

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	899	Identity:	202/899 - (22%)
Similarity:	362/899 - (40%)	Gaps:	193/899 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LSNSDSEEHFSTTIKHLNFDQQYVPRKVTYYDKTIRMDKNPIKTVF------------NVCDKLI 97
            ::|.:.....::..:.:|:...|     ..|.|..||.:..|..||            ::||.:.
  Fly    62 VANQEVGTSLTSLKEEVNYGDAY-----QSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMD 121

  Fly    98 ENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQAD 162
            ...:|:.:..:.:              ||                  |:|.          |.||
  Fly   122 IPHIYSYMSENAE--------------GF------------------NLHP----------HPAD 144

  Fly   163 V---WLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESFT 224
            :   ...:::.|.:|:.|.::.| .:...||....|.       :....||..::.::.:|....
  Fly   145 LAKALYSLITEFNWTRFIFLYES-AEYLNILNELTTM-------LGKSGTVITVLRYDMQLNGNY 201

  Fly   225 EHLID--MKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFSNNTPD------G 281
            :.::.  .|:..:|: ::..|:|........|.:..:..|.:.:|:......|.:..:      .
  Fly   202 KQVLRRVRKSVDNRI-VVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEAN 265

  Fly   282 VLGLQLEHAH--------------SDKGHIR--------------DSVYVLASAIKEMISNETIA 318
            :.||:|....              :|:...|              |:|.:.|..:|    |....
  Fly   266 ITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQTLK----NLPFK 326

  Fly   319 EAPKDCGDSAVN-WESGKRLFQYLKSRNITGE--TGQVAFDDNGDRIYAGY--DVINIREQQKKH 378
            ..|::|.....: .:.|.....|:::..:|..  ||.:.|:.|   :..||  |||   |.|...
  Fly   327 PMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGN---VRKGYHLDVI---ELQPSG 385

  Fly   379 VVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPF-----VYVRRMGD 438
            :|...::|..|.....|:..:...:....    ..:...|.:.||::..||:     .|.:..|:
  Fly   386 IVKVGTWDEDRQYRPQRLAPTTAQFDSVD----NSLANKTFIILLSVPNKPYAQLVETYKQLEGN 446

  Fly   439 DEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRI--NFTYDLALSPDGQFGHYILRN 501
            .::                        .||.:||:.||:.::  |||:   ::....:|.|....
  Fly   447 SQY------------------------EGYGVDLIKELADKLGFNFTF---VNGGNDYGSYNKST 484

  Fly   502 NTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSS-TL 565
            |        |.||::.|::..|||:.:..|||..||.:.::|:.||...||.||..||.::: .|
  Fly   485 N--------ESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPEL 541

  Fly   566 VSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPF---GRFKLSHSDSNEEKALNLSSAVWFAWG 627
            .:|:.|||..:|..:..|...|:|..::|.|.||.   ..:.........|....|.:::||..|
  Fly   542 FTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTG 606

  Fly   628 VLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTME 692
            .||..| .|..|::.|.|.:...|..|.:|:|:||||||||||.:|:|::.::.::|  |.:..:
  Fly   607 ALLQQG-SEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDD--LADNKD 668

  Fly   693 NLTCATVKGSSVDMYFRRQVE--LSNMYRTMEAN-NYATAE--QAIQDVKKGKLMAFIWDSSRLE 752
            .:.....|..|...:|....|  ...|.:.|..| .|.|.:  :.:..||.....||:.:|:.:|
  Fly   669 GVVYGAKKTGSTRNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIE 733

  Fly   753 YEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQW---IFHGHVQ 814
            |...::|.|...|:.....||||.::|..|.......|:||..|.|.:||:..:|   :..|
  Fly   734 YNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTG--- 795

  Fly   815 QNCELFEKTPNT--LGLKNMAGVF--ILVGVGIAGGVGLI--IIEVIYKKHQVK 862
             .|...|..|:.  |.:.|:.|||  :|||...|...|:|  ::.|:.|.|..:
  Fly   796 -ICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYR 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	68/415 (16%)
		ANF_receptor	58..371	CDD:279440	61/368 (17%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	117/419 (28%)
		HisJ	451..>558	CDD:223904	31/108 (29%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	43/138 (31%)
		Lig_chan	575..838	CDD:278489	80/277 (29%)
		CaM_bdg_C0	854..882	CDD:287524	3/9 (33%)
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	66/399 (17%)
		ANF_receptor	51..382	CDD:279440	63/385 (16%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	116/408 (28%)
		Lig_chan	551..824	CDD:278489	81/279 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462866
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.940