DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and Ir7g

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001368933.1	Gene:	Ir7g / 31694	FlyBaseID:	FBgn0029968	Length:	607	Species:	Drosophila melanogaster

Alignment Length:	461	Identity:	102/461 - (22%)
Similarity:	165/461 - (35%)	Gaps:	127/461 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   450 CPL---------FNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGA 505
            |||         |.:.|....|.  ||....||.|||:|:||:...:...|.      |:|.|
  Fly   212 CPLIVLARKVSPFLDLDEGQREL--RGLEGRLLQELSRRMNFSIQFSGLQDQ------LKNRT-- 266

  Fly   506 MTLRKEWT--GLIGELVNERADMIVAPLTIN--PERAEYIEFSKPF------KYQGITILEKKPS 560
                 .||  .|:.:||.||    :|.|.|.  .:|.:|.....|.      :..|..:|.....
  Fly   267 -----TWTEKQLLQKLVQER----IAHLAIGYVRKRIQYATNLTPVFPHYSNRVVGCLLLNAHNL 322

  Fly   561 RSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFA 625
            .|..:.||  ||....||.::.|...::.:..|..|            .:.:..||.|  ||:.|
  Fly   323 TSLEIWSF--PFQALTWICLVFSFLSISCLALLHXR------------GAGDRLALVL--AVYAA 371

  Fly   626 WGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNT 690
                 :.|:....|...|.::|...|..|.:|:.:.|:|.|  |.:|.....:       ||...
  Fly   372 -----SLGLPIDPPERPSLQLLFASWLIFGLIVRSMYSALL--FFILRYHLHQ-------RLPGN 422

  Fly   691 MENLT---CATVKGSSV--DMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSR 750
            :::||   .|.|.|.:.  |:   |:|                  .::||:.  .|.:.|..|.|
  Fly   423 LQDLTHGDYAAVMGRTTLQDL---REV------------------PSLQDLL--GLKSVIVTSER 464

  Fly   751 LEYEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGF-----MEKLDKQWIF- 809
             |.|..:..:..|..|..|......||..    .||:.......|.:|.     .:.|::|...
  Fly   465 -EEEVLRTLDRCTLREGAGSHPLFFGLIS----QDALLHLTQRGHRAGAYHIIPQDVLEQQLAIY 524

  Fly   810 ---HGHVQQNCELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIAR 871
               |.|:..:.:....:..::||             :....|.:..|..::...:.::||:
  Fly   525 LQKHSHLASHLDHLVMSIRSVGL-------------VHHWAGQMASERYFRSRFLYREKRI---- 572

  Fly   872 HAADKW 877
            ...|.|
  Fly   573 RQPDLW 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374
		ANF_receptor	58..371	CDD:279440
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	94/400 (24%)
		HisJ	451..>558	CDD:223904	34/125 (27%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	32/142 (23%)
		Lig_chan	575..838	CDD:278489	56/276 (20%)
		CaM_bdg_C0	854..882	CDD:287524	4/24 (17%)
Ir7g	NP_001368933.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463043
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840