DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar1 and Ir7c

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster

Alignment Length:	467	Identity:	89/467 - (19%)
Similarity:	183/467 - (39%)	Gaps:	101/467 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   446 DERPCPLFNNSDATANEFCCRGYCIDLLI--ELSKRINFTYDLA---------LSPDGQFGHYIL 499
            :.||..:..:...|.......|  |:.||  .|::|:|||..|.         :.|||.|
  Fly   222 EHRPYVIIEDDPKTPGGRSIHG--IEGLIFRSLAERMNFTIKLVEQKDKNRGEILPDGNF----- 279

  Fly   500 RNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSST 564
                         ||::..:|:...::.......:..|::.:..|..:....|.::.......|.
  Fly   280 -------------TGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPIVLVVPSGGSISP 331

  Fly   565 LVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWF--AWG 627
            :....:||...:|..::||: :...||..|        .|::.........|...:.:.|  .|.
  Fly   332 MGRLTRPFRYIIWSCILVSL-IFGFVLICL--------LKITALPGLRNLVLGRRNRLPFMGMWA 387

  Fly   628 VLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTME 692
            .|| .|:....|:...||.:.::|....:|:.|:||..|  :|:|:          |..:|:.::
  Fly   388 SLL-GGLALYNPQRNFARYILVMWLLQTLILRAAYTGQL--YLLLQ----------DVEMRSPIK 439

  Fly   693 NLTCATVKGSSVDMYFRRQVELSNMYR-TMEANNY---ATAEQAIQDVK----KGKLMAFIWDS- 748
            :|:....|    |..||....|..::: :|...|:   .:.|:::..::    .|..:|.:..:
  Fly   440 SLSEVLAK----DYEFRILPALRTIFKDSMPTTNFHAVLSLEESLYRLRDEDDPGITVALLQPTV 500

  Fly   749 SRLEYEASKDCE--------LVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDK 805
            ::.::.:..:..        |:||...|    |   ::..|.:...:...|:....||.:.:..|
  Fly   501 NQFDFRSGPNKRHLTVLPDPLMTAPLTF----Y---MRPHSYFKRRIDRLIMAMMSSGIVARYRK 558

  Fly   806 QW---IFHGHVQQNCELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLI-----IIEVIYKKHQVK 862
            .:   |.....::|.|     |..|.:..::|:|:     ...|:.|:     |:|::...|:..
  Fly   559 MYMDRIKRVSKRRNLE-----PKPLSIWRLSGIFV-----CCAGLYLVALIVFILEILTTNHRRL 613

  Fly   863 KQKRLDIARHAA 874
            ::....|.|:||
  Fly   614 RRAFNVINRYAA 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374
		ANF_receptor	58..371	CDD:279440
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	75/404 (19%)
		HisJ	451..>558	CDD:223904	21/117 (18%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	23/136 (17%)
		Lig_chan	575..838	CDD:278489	54/284 (19%)
		CaM_bdg_C0	854..882	CDD:287524	5/21 (24%)
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	18/81 (22%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	54/292 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463035
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840