DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar1 and Grik3

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	952	Identity:	241/952 - (25%)
Similarity:	410/952 - (43%)	Gaps:	184/952 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PSTYNIGGVLSNSD--------SEEH---FSTTIKHLNFDQQYVPRKVTYYDKTIRMDKNPIKTV 89
            |....|||:...:|        :|||   ||..|  :|.::..:|.....||.......:..:..
  Rat    33 PHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANI--INRNRTLLPNTTLTYDIQRIHFHDSFEAT 95

  Fly    90 FNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTV 154
            ...||:|    ...||.....:.|..:.|..|..:.. .:|.|.:..:.....:|:  ..::...
  Rat    96 KKACDQL----ALGVVAIFGPSQGSCTNAVQSICNAL-EVPHIQLRWKHHPLDNKD--TFYVNLY 153

  Fly   155 PPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFE-- 217
            |.|...:...|:::....:....::: .|:.|...|.........|...:.:|   :|.::.:
  Rat   154 PDYASLSHAILDLVQSLKWRSATVVY-DDSTGLIRLQELIMAPSRYNIRLKIR---QLPIDSDDS 214

  Fly   218 -PKLESFTEHLIDMKTAQS-RVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFS-NNTP 279
             |.|:       :||..:. |:....:.|..||:: :.|....|..|.:.:|.|...|:: :..|
  Rat   215 RPLLK-------EMKRGREFRIIFDCSHTMAAQIL-KQAMAMGMMTEYYHFIFTTLDLYALDLEP 271

  Fly   280 DGVLGLQL---EHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPK-DCG--------DSA---- 328
            ....|:.|   ...:.|..|:        |||.|..|.|.:..||: :.|        |:|
  Rat   272 YRYSGVNLTGFRILNVDNPHV--------SAIVEKWSMERLQAAPRAESGLLDGVMMTDAALLYD 328

  Fly   329 ----------------VN---------WESGKRLFQYLKSRNITGETGQVAFD-DNGDRIYAGYD 367
                            ||         |..|.|...::|.....|.||::.|: .:|.|.....|
  Rat   329 AVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLD 393

  Fly   368 VINIREQQKKHVVGKFS-YDSMR----AKMR-MRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIE 426
            :|:::|...:. ||.:| .|.:.    ||.| ..:.||               :....|.:.|:.
  Rat   394 IISLKEDGLEK-VGVWSPADGLNITEVAKGRGPNVTDS---------------LTNRSLIVTTLL 442

  Fly   427 EKPFVYVRR-----MGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDL 486
            |:|||..|:     .|:|.|                        .|||||||.||:..:.|:|::
  Rat   443 EEPFVMFRKSDRTLYGNDRF------------------------EGYCIDLLKELAHILGFSYEI 483

  Fly   487 ALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQG 551
            .|..||::         ||...:.:|.|::.||::.:||:.||||||...|.:.|:|||||...|
  Rat   484 RLVEDGKY---------GAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLG 539

  Fly   552 ITILEKKPSRSS-TLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKA 615
            ::||.:||:.:: ::.|||.|.|..:|:.|:::...|:.||:::.||||:..:.....:...|..
  Rat   540 VSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVV 604

  Fly   616 LN---LSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKT 677
            .|   |.::.||..|.|:..| .|..|::.|.|::|.:|..|.:||::||||||||||.:||.::
  Rat   605 ENNFTLLNSFWFGMGSLMQQG-SELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMES 668

  Fly   678 KLSGINDARLRNTME------NLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDV 736
            .:...:|...:..:|      ..|....|.|.:..:.:....:|:....:..||    |:.||..
  Rat   669 PIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNN----EEGIQRT 729

  Fly   737 KKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFME 801
            .... .|.:.:|:.:||...::|.|...|.|....|||||...|||:.|.:|:|||:..|...:.
  Rat   730 LTAD-YALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLH 793

  Fly   802 KLDKQWIFHGHVQQNC-ELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQK 865
            .:.::| :.|   ..| |...|..:.||::.:.|:||::..|:...|.:.:.|.|||..:..:::
  Rat   794 IMKEKW-WRG---SGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKTAERE 854

  Fly   866 RLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLNSTHAP 907
            :.......||:          ||.||..||:..      |.|
  Rat   855 QRSFCSTVADE----------IRFSLTCQRRLK------HKP 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	89/432 (21%)
		ANF_receptor	58..371	CDD:279440	69/359 (19%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	129/416 (31%)
		HisJ	451..>558	CDD:223904	38/106 (36%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	49/138 (36%)
		Lig_chan	575..838	CDD:278489	80/272 (29%)
		CaM_bdg_C0	854..882	CDD:287524	5/27 (19%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	83/412 (20%)
		ANF_receptor	55..398	CDD:279440	74/371 (20%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	127/407 (31%)
		Lig_chan	564..832	CDD:278489	81/277 (29%)
		Glutamate binding	690..692		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910