DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and GRIN2C

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	XP_016880033.1	Gene:	GRIN2C / 2905	HGNCID:	4587	Length:	1337	Species:	Homo sapiens

Alignment Length:	1006	Identity:	277/1006 - (27%)
Similarity:	458/1006 - (45%)	Gaps:	149/1006 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 NPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYS----IPVIGISSRDA-AFSD 143
            ||...:..:|..|....|:.:|.     ..::...||:....|.|    :|::.||...| ..:.
Human   148 NPSSLLTQICGLLGAAHVHGIVF-----EDNVDTEAVAQILDFISSQTHVPILSISGGSAVVLTP 207

  Fly   144 KNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIII------HSSDTDG-RAILGRFQTTSQTYY 201
            |....:||:.......|..|..::|..:.::...:|      |:...:| ||:    ...|...:
Human   208 KEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAV----ADASHVSW 268

  Fly   202 DDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVW 266
            ..:|| .|:|| ....|:..  |:.|  ::...:.|::.|.|.|:|:|:|.:|.:..:.|.||||
Human   269 RLLDV-VTLEL-GPGGPRAR--TQRL--LRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVW 327

  Fly   267 IVTEQALFSNNTPD-----GVLGLQLEHAH-SDKGHIRDSVYVLASAIKEMISNETIAEAPKDCG 325
            :|...||.|.:.|.     |::.:..|... |.:..:||.|.:||..............||  .|
Human   328 LVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYWRQHGTLPAP--AG 390

  Fly   326 DSAVN---WESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHVVGKFSYDS 387
            |..|:   ....:..| |....|:|.|....:|...|..:.....||.:...:...:||::.:..
Human   391 DCRVHPGPVSPAREAF-YRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRWEHGV 454

  Fly   388 MRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPC-- 450
            :..|..        :|| :.....:.::...||.:.|:||:|||.|.........|.|:..||
Human   455 LYMKYP--------VWP-RYSASLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRR 510

  Fly   451 ---PLFNNSD-ATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKE 511
               ..|::.| |...:.||:|:|||:|.:|::.:.|:|||.|..:|:.|..:          |..
Human   511 QSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRV----------RGV 565

  Fly   512 WTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTL 576
            |.|:|||:..:||||.:..||||.||:|.::||.||...||:::..:.:.:.:..:||:|:|..:
Human   566 WNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAV 630

  Fly   577 WILVMV-SVHVVALVLYLLDRFSPFG-RFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTP 639
            |:::.| .:.|||:.:::.:.|||.. ...|:....:...|..:..:||..|.::.|:.:....|
Human   631 WVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENP 695

  Fly   640 RSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDAR---LRNTMENLT-----C 696
            |..:::::.:|||.||:|.:||||||||||::.|:....:||::|.:   |.||....|     |
Human   696 RGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKSLHLENTGVAWTAFKTFC 760

  Fly   697 ATVKGSSVDMY--FR--------RQVELSNMYRTMEAN----NYATAEQAIQDVKKG-------- 739
            :.......|.|  ||        .:..:.:.||.|..:    |..:.|.|:..:|.|
Human   761 SDYFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGSEAQPVPR 825

  Fly   740 KLMAFIWDSSRLEYEASKD--CELVT--AGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFM 800
            ||.|||:|::.|.|.|.||  |:|||  :|::|..:||||.:||.|.|..|:.||:|:|...|..
Human   826 KLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGET 890

  Fly   801 EKLDKQWIFHGHVQQNCELFEKTPNTLGLKNMAGVF--ILVGVGIAGGVGLIII---EVIYKK-- 858
            :||:..|:  ..:.|| |..|...:.|.:.||||||  :||.:|:|    |::.   .::|.|
Human   891 QKLETVWL--SGICQN-EKNEVMSSKLDIDNMAGVFYMLLVAMGLA----LLVFAWEHLVYWKLR 948

  Fly   859 HQVKKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLNSTHAPGTI--SLAVDKRRYPR 921
            |.|....:||.....:   ||.......:::..:..||.:..|.::.|..::  .|...:.....
Human   949 HSVPNSSQLDFLLAFS---RGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAARDMVTT 1010

  Fly   922 LGQRLGPERA------WPGDAADVLRIRR-----PYELGNPGQSPKVMAANQPGMPMP------- 968
            .|.....:||      |.|.       ||     |......|.||.:...:.|..|.|
Human  1011 AGVSSSLDRATRTIENWGGG-------RRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGWGPPD 1068

  Fly   969 ----MLGKTRPQQSVLPPRYSPGYTSDVSHL 995
                .|.:..||....||...|. .||||.:
Human  1069 GGRAALVRRAPQPPGRPPTPGPP-LSDVSRV 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	78/341 (23%)
		ANF_receptor	58..371	CDD:279440	74/307 (24%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	147/442 (33%)
		HisJ	451..>558	CDD:223904	41/107 (38%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	40/136 (29%)
		Lig_chan	575..838	CDD:278489	98/300 (33%)
		CaM_bdg_C0	854..882	CDD:287524	8/29 (28%)
GRIN2C	XP_016880033.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910