Protein Alignment Nmdar1 and GRIN2B

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: NP_000825.2
• Gene: GRIN2B / 2904
• HGNCID: 4586
• Length: 1484
• Species: Homo sapiens
• Alignment Length: 970
• Identity: 276/970 - (28%)
• Similarity: 456/970 - (47%)
• Gaps: 153/970 - (15%)

  Fly     9 CRPLFGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSE-----EHFSTTIKHLNFDQQYV 68
            |.|.|.|.:.:|..   :..|..:..:|.:..|..:|..:..|     .|......||:    .|
Human     8 CSPKFWLVLAVLAV---SGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLS----VV 65

  Fly    69 PRKVTYYDKTIRMDK-NPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVI 132
            ||.     :.:.|:: :|...:..:||.:.:.::..||.: :.|..:.....:.:.|.....|::
Human    66 PRV-----ELVAMNETDPKSIITRICDLMSDRKIQGVVFA-DDTDQEAIAQILDFISAQTLTPIL 124

  Fly   133 GI-SSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTT 196
            || .......:||:....|.:..|....||.|.|.::..:.:....|:               ||
Human   125 GIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIV---------------TT 174

  Fly   197 SQTYYDDV--DVRATVE-LIVEFEPKLESFTEHLIDM-------------KTAQSRVYLMYASTE 245
            ....|.|.  .:|:|:| ..|.:|  ||...  |:||             |..||.:.|:|.:.|
Human   175 YFPGYQDFVNKIRSTIENSFVGWE--LEEVL--LLDMSLDDGDSKIQNQLKKLQSPIILLYCTKE 235

  Fly   246 DAQVIFRDAGEYNMTGEGHVWIVTEQALFSNNT-----PDGVLGLQL-EHAHSDKGHIRDSVYVL 304
            :|..||..|....:||.|:.|||........:|     |.|::.:.. |..:.....:||.:.::
Human   236 EATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAII 300

  Fly   305 ASAIKEMISNETIAEAPKDCGDSAVNWESGKRLFQ------YLKSRNITGETGQVAFDDNGDRIY 363
            .:|..:|:|..:....||   .|..|... ||::|      ||  .|:|.|...::|.::|.:::
Human   301 TTAASDMLSEHSFIPEPK---SSCYNTHE-KRIYQSNMLNRYL--INVTFEGRNLSFSEDGYQMH 359

  Fly   364 AGYDVINIREQQKKHVVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPT------HLRL 422
            ....:|.:.:::|...|||:...|::.|.        .:||   |..||     |      ||.:
Human   360 PKLVIILLNKERKWERVGKWKDKSLQMKY--------YVWP---RMCPE-----TEEQEDDHLSI 408

  Fly   423 LTIEEKPFVYVRRMGDDEFRCEPDERPCP----LFNNSDATAN--EFCCRGYCIDLLIELSKRIN 481
            :|:||.|||.|..:......|..:..||.    ..|.:|....  :.||:|:|||:|.::||.:.
Human   409 VTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVK 473

  Fly   482 FTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKP 546
            |||||.|..:|:.|..|  |.|        |.|:|||:|.:||.|.|..||||.||:|.::||.|
Human   474 FTYDLYLVTNGKHGKKI--NGT--------WNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVP 528

  Fly   547 FKYQGITILEKKPSRSSTLVS---FLQPFSNTLWILVMVSVHVV-ALVLYLLDRFSPFGRFKLSH 607
            |...||:::   .|||:..||   ||:|||..:|:::.|.:.:| |:.:::.:.|||.| :....
Human   529 FIETGISVM---VSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVG-YNRCL 589

  Fly   608 SDSNEE--KALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFL 670
            :|..|.  .:..:..|:|..||::.|:.:....|:..:::::..|||.||:|.:||||||||||:
Human   590 ADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFM 654

  Fly   671 VLERPKTKLSGINDARLRNTME---NLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQA 732
            :.|....::||::|.:.:...:   .....||...|.:...|.  ..:.|:..|...|....:.|
Human   655 IQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRN--NYAEMHAYMGKFNQRGVDDA 717

  Fly   733 IQDVKKGKLMAFIWDSSRLEYEASKD--CELVT--AGELFGRSGYGIGLQKGSPWTDAVTLAILE 793
            :..:|.|||.|||:|::.|.|.|.:|  |:|||  :|::|..:||||.:||.|.|...|.||||:
Human   718 LLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQ 782

  Fly   794 FHESGFMEKLDKQWIFHG--HVQQNCELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIY 856
            ....|.||:|:..|: .|  |.::|    |...:.|.:.||||||.::|..:|..:...|.|.::
Human   783 LFGDGEMEELEALWL-TGICHNEKN----EVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLF 842

  Fly   857 K---KH------QVKKQKRLDIARHAADKWRG-TIEKRKTIRASLAMQRQYNVGLNSTHA 906
            .   :|      ..|......|:|.......| .||:|:::..|      ....:|:||:
Human   843 YWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNS------PTATMNNTHS 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	90/402 (22%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	151/427 (35%)
		CaM_bdg_C0	854..882	CDD:402271	5/37 (14%)
GRIN2B	NP_000825.2	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	88/389 (23%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	148/416 (36%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94	604..623		5/18 (28%)
		NMDAR2_C	840..1484	CDD:463148	12/63 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1074..1097
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1271..1301
		Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097	1292..1304
		PDZ-binding. /evidence=ECO:0000250	1482..1484