Protein Alignment Nmdar1 and GRIK5

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Alignment Length: 901
• Identity: 229/901 - (25%)
• Similarity: 381/901 - (42%)
• Gaps: 171/901 - (18%)

  Fly    41 IGGVLSNSDSEEHFSTTIKHLNFDQQYVPRKVTYYDKTIRMDKNPIKTVFNVCDKLIENRVYAVV 105
            |.|:: ...::......|..|..|.||                   :|...:| :::...|.:|:
Human    51 INGII-EVPAKARVEVDIFELQRDSQY-------------------ETTDTMC-QILPKGVVSVL 94

  Fly   106 VSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLR--TVPPYYHQADVWL--- 165
               ..:|...|.:.||:..|...||.|.:...:..      .:.:||  :|..|....||.|
Human    95 ---GPSSSPASASTVSHICGEKEIPHIKVGPEETP------RLQYLRFASVSLYPSNEDVSLAVS 150

  Fly   166 EMLSHFAYTKVIIIHSS-------DTDGRAILGRFQTTSQTYYDDVDVRATVELIVEF-EPKLES 222
            .:|..|.|....:|.:.       :...|..|...:|.|....|  |.|....|:.|. :.|:.:
Human   151 RILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLD--DSRDPTPLLKEIRDDKVST 213

  Fly   223 FTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQ---------------- 271
            .   :||            |:...:.:|.|.|.|..||...:.:|:|..
Human   214 I---IID------------ANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSN 263

  Fly   272 ----ALFSNN---TPDGVLGLQLEHAHSDKGH-----------IRDSVYVLASAIKEMISNETIA 318
                ::|:.:   .|:.|..|.:....:.:..           :.|:|:|:.||::|:..::.|.
Human   264 ILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIG 328

  Fly   319 EAPKDCGDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKH-VVGK 382
            ..|..| .||..|..|..|..||:.....|.||:|.|:..|.|  ..|.:..:.:.::.| .:|.
Human   329 VKPLAC-TSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQR--TNYTLRILEKSRQGHREIGV 390

  Fly   383 FSYDSMRAKMR---MRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCE 444
            : |.:....|.   :.||.|:             .:....|.:.||.|.|:|.
Human   391 W-YSNRTLAMNATTLDINLSQ-------------TLANKTLVVTTILENPYVM------------ 429

  Fly   445 PDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLR 509
              .||     |..|.:......|:|:|:|.||::.:.|.|.|.|..||.:         ||....
Human   430 --RRP-----NFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLY---------GAPEPN 478

  Fly   510 KEWTGLIGELVN-ERADMIVAPLTINPERAEYIEFSKPFKYQGITILEK-KPSRSSTLVSFLQPF 572
            ..|||::|||:| ::||:.||..||..||.:.|:|||||...||:||.: ...|.....|||.||
Human   479 GSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPF 543

  Fly   573 SNTLWILVMVSVHVVALVLYLLDRFSPFGRFK----LSHSDSNEEKALNLSSAVWFAWGVLLNSG 633
            |..:|:.::::...|:.||:|..|.||:..:.    |.......|....|.:::||..|..:..|
Human   544 SPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQG 608

  Fly   634 IGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCAT 698
             .|..||:.|.|.:..||..|.:||::||||||||||.::|.:..:...:|..   ...|:...|
Human   609 -SEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLA---DQTNIEYGT 669

  Fly   699 VKGSSVDMYFRRQVELSNMYRTMEAN-NYATAEQA---IQDVKKG------KLMAFIWDSSRLEY 753
            :...|...:|:     ::.|:|.:.. ||..::|.   ::..::|      ...||:.:|:..||
Human   670 IHAGSTMTFFQ-----NSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEY 729

  Fly   754 EASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCE 818
            ....:|.|...|.|....|||||:..|||:.|.:|||||:..|:..:|.|.::|...|...:.
Human   730 HRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKE-- 792

  Fly   819 LFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAA 874
             .:.....||::|:.|:||::..|:...|.:.::|.|:...:..:.:.......||
Human   793 -EDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEETPALHPAA 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	86/414 (21%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	131/416 (31%)
		CaM_bdg_C0	854..882	CDD:402271	3/21 (14%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	83/400 (21%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	130/407 (32%)