DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar1 and GRIK4

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	914	Identity:	225/914 - (24%)
Similarity:	386/914 - (42%)	Gaps:	206/914 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 IPVIGISSRDAAFS-------DKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTK--VIIIHSSDT 184
            :.|:|.||..|:.|       :|.:         |::..|.   |....|.:.:  .:.:|.|:|
Human    92 VAVLGPSSSPASSSIISNICGEKEV---------PHFKVAP---EEFVKFQFQRFTTLNLHPSNT 144

  Fly   185 D----GRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESF------------------TEHL 227
            |    ...||..|..|:...     :.|..|.::..|..|..|                  |..|
Human   145 DISVAVAGILNFFNCTTACL-----ICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLL 204

  Fly   228 IDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFSNNTPD-------GVLGL 285
            .:::..::...:::|:...:..|...|.|..|....:.:|.|... ||....|       .:||.
Human   205 KEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLE-FSLQRMDSLVDDRVNILGF 268

  Fly   286 QL---EHA-------------HSDKGHIR------------DSVYVLASAIKEMISNETIAEAPK 322
            .:   .||             ..:..|:.            |:||.:.:|::|:..::.|...|.
Human   269 SIFNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPL 333

  Fly   323 DCGDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVI-----NIREQQKKHVVGK 382
            .|| ||..|:.|..|..||:...:.|.||.:.|:..|.|......::     ..|:..:.||...
Human   334 SCG-SAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEG 397

  Fly   383 FSYDS-MRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPD 446
            .|.|| :.|.   .|:|:               :..|.|.:.||.|.|::.::.
Human   398 LSMDSHLYAS---NISDT---------------LFNTTLVVTTILENPYLMLKG----------- 433

  Fly   447 ERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKE 511
                   |:.:...|: ...|:|:|:|.||::.:.|.|.:.|..||.:|   :....|.
Human   434 -------NHQEMEGND-RYEGFCVDMLKELAEILRFNYKIRLVGDGVYG---VPEANGT------ 481

  Fly   512 WTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEK-KPSRSSTLVSFLQPFSNT 575
            |||::|||:..:||:.||.|||..||.:.|:|||||...||:||.: ...|.....|||.|||..
Human   482 WTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPG 546

  Fly   576 LWILVMVSVHVVALVLYLLDRFSPF----------GRFKLSHSDSNEEKALNLSSAVWFAWGVLL 630
            :|:.::::...|:.||:|:.|.:|:          ||..|..:.      .:|.:::||..|..:
Human   547 VWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQ------YSLGNSLWFPVGGFM 605

  Fly   631 NSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLT 695
            ..| ....||:.|.|.:..||..|.:||::||||||||||.::|....:..::|...:..:|
Human   606 QQG-STIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIE--- 666

  Fly   696 CATVKGSSVDMYFRRQVELSNMYRTMEAN-NYATAEQA---IQDVKKG------KLMAFIWDSSR 750
            ..|:.|.|...:|:     ::.|:|.:.. ||..::|.   ::..::|      ...||:.:|:.
Human   667 YGTIHGGSSMTFFQ-----NSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTM 726

  Fly   751 LEYEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQ 815
            .||...::|.|...|.|....|||||:..||.:.|...||||:..|:..:|.|.::|...|
Human   727 NEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGG---- 787

  Fly   816 NCELFEKTPNT-------LGLKNMAGVFILVGVGIAGGVGLIIIEVIYK-KHQVKKQKRLDIARH 872
                  |.|..       ||::|:.|:|:::..|:...:.:.::|.::. :|  .:...:.:.:.
Human   788 ------KCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRH--SEATEVSVCQE 844

  Fly   873 AADKWRGTIEKRKTI-----RASLAMQRQYNVGLNSTHAP-GTISLAVDK----RRYPRLGQRLG 927
            ...:.|..|..:.:|     ||::...|.   .:.....| ||.:|:..|    ....:|.|||.
Human   845 MVTELRSIILCQDSIHPRRRRAAVPPPRP---PIPEERRPRGTATLSNGKLCGAGEPDQLAQRLA 906

  Fly   928 PERA 931
            .|.|
Human   907 QEAA 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	72/347 (21%)
		ANF_receptor	58..371	CDD:279440	63/312 (20%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	126/421 (30%)
		HisJ	451..>558	CDD:223904	40/107 (37%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	48/145 (33%)
		Lig_chan	575..838	CDD:278489	80/289 (28%)
		CaM_bdg_C0	854..882	CDD:287524	2/28 (7%)
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	66/326 (20%)
		ANF_receptor	43..382	CDD:279440	63/308 (20%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	125/412 (30%)
		Lig_chan	547..816	CDD:278489	80/293 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910