DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar1 and GRIK3

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_000822.2	Gene:	GRIK3 / 2899	HGNCID:	4581	Length:	919	Species:	Homo sapiens

Alignment Length:	952	Identity:	239/952 - (25%)
Similarity:	408/952 - (42%)	Gaps:	184/952 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PSTYNIGGVLSNSD--------SEEH---FSTTIKHLNFDQQYVPRKVTYYDKTIRMDKNPIKTV 89
            |....|||:...:|        :|||   ||..|  :|.::..:|.....||.......:..:..
Human    33 PHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANI--INRNRTLLPNTTLTYDIQRIHFHDSFEAT 95

  Fly    90 FNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTV 154
            ...||:|    ...||.....:.|..:.|..|..:.. .:|.|.:..:.....:|:  ..::...
Human    96 KKACDQL----ALGVVAIFGPSQGSCTNAVQSICNAL-EVPHIQLRWKHHPLDNKD--TFYVNLY 153

  Fly   155 PPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFE-- 217
            |.|...:...|:::.:..:....::: .|:.|...|.........|...:.:|   :|.::.:
Human   154 PDYASLSHAILDLVQYLKWRSATVVY-DDSTGLIRLQELIMAPSRYNIRLKIR---QLPIDSDDS 214

  Fly   218 -PKLESFTEHLIDMKTAQS-RVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFS-NNTP 279
             |.|:       :||..:. |:....:.|..||:: :.|....|..|.:.:|.|...|:: :..|
Human   215 RPLLK-------EMKRGREFRIIFDCSHTMAAQIL-KQAMAMGMMTEYYHFIFTTLDLYALDLEP 271

  Fly   280 DGVLGLQL---EHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKD------------------ 323
            ....|:.|   ...:.|..|:        |||.|..|.|.:..||:.
Human   272 YRYSGVNLTGFRILNVDNPHV--------SAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYD 328

  Fly   324 -------CGDSA----VN---------WESGKRLFQYLKSRNITGETGQVAFD-DNGDRIYAGYD 367
                   |...|    ||         |..|.|...::|.....|.||::.|: .:|.|.....|
Human   329 AVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLD 393

  Fly   368 VINIREQQKKHVVGKFS-YDSMR----AKMR-MRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIE 426
            :|:::|...:. ||.:| .|.:.    ||.| ..:.||               :....|.:.|:.
Human   394 IISLKEDGLEK-VGVWSPADGLNITEVAKGRGPNVTDS---------------LTNRSLIVTTVL 442

  Fly   427 EKPFVYVRR-----MGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDL 486
            |:|||..|:     .|:|.|                        .|||||||.||:..:.|:|::
Human   443 EEPFVMFRKSDRTLYGNDRF------------------------EGYCIDLLKELAHILGFSYEI 483

  Fly   487 ALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQG 551
            .|..||::         ||...:.:|.|::.||::.:||:.||||||...|.:.|:|||||...|
Human   484 RLVEDGKY---------GAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLG 539

  Fly   552 ITILEKKPSRSS-TLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKA 615
            ::||.:||:.:: ::.|||.|.|..:|:.|:::...|:.||:::.||||:..:.....:...|..
Human   540 VSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVV 604

  Fly   616 LN---LSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKT 677
            .|   |.::.||..|.|:..| .|..|::.|.|::|.:|..|.:||::||||||||||.:||.::
Human   605 ENNFTLLNSFWFGMGSLMQQG-SELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMES 668

  Fly   678 KLSGINDARLRNTME------NLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDV 736
            .:...:|...:..:|      ..|....|.|.:..:.:....:|:....:..||    |:.||..
Human   669 PIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNN----EEGIQRA 729

  Fly   737 KKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFME 801
            .... .|.:.:|:.:||...::|.|...|.|....|||||...|||:.|.:|:|||:..|...:.
Human   730 LTAD-YALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLH 793

  Fly   802 KLDKQWIFHGHVQQNC-ELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQK 865
            .:.::| :.|   ..| |...|..:.||::.:.|:||::..|:...|.:.:.|.:||..:..:::
Human   794 IMKEKW-WRG---SGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAERE 854

  Fly   866 RLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLNSTHAP 907
            :.......||:          ||.||..||:..      |.|
Human   855 QRSFCSTVADE----------IRFSLTCQRRVK------HKP 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	88/432 (20%)
		ANF_receptor	58..371	CDD:279440	68/359 (19%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	129/416 (31%)
		HisJ	451..>558	CDD:223904	38/106 (36%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	49/138 (36%)
		Lig_chan	575..838	CDD:278489	80/272 (29%)
		CaM_bdg_C0	854..882	CDD:287524	4/27 (15%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	82/412 (20%)
		ANF_receptor	55..398	CDD:279440	73/371 (20%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	127/407 (31%)
		Lig_chan	564..832	CDD:278489	81/277 (29%)
		Glutamate binding. /evidence=ECO:0000250	690..692		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910