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Protein Alignment Nmdar1 and GRIK2

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	982	Identity:	249/982 - (25%)
Similarity:	424/982 - (43%)	Gaps:	190/982 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFCRPLFGLAIVLLVAP--IDAAQRHTASDNPSTYNIGGVLSNSDS------EEHFSTTIKHLNF 63
            :...|:|...:.||:..  |..:|..|     .....||:....:|      |..|...:..:|.
Human     7 ILSNPVFRRTVKLLLCLLWIGYSQGTT-----HVLRFGGIFEYVESGPMGAEELAFRFAVNTINR 66

  Fly    64 DQQYVP--------RKVTYYDKTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAV 120
            ::..:|        :|:..||......|        .||:|..........||..::.     ||
Human    67 NRTLLPNTTLTYDTQKINLYDSFEASKK--------ACDQLSLGVAAIFGPSHSSSAN-----AV 118

  Fly   121 SYTSGFYSIPVIGISSRDAAFSDK-NIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDT 184
            ........:|.|....:.....:| :.:||.   .|.:...:...|:::..|.:..|.::: .|:
Human   119 QSICNALGVPHIQTRWKHQVSDNKDSFYVSL---YPDFSSLSRAILDLVQFFKWKTVTVVY-DDS 179

  Fly   185 DGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQV 249
            .|...|.........|...:.:|.......:.:|.|:       :||..:....:...|.|.|..
Human   180 TGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLK-------EMKRGKEFHVIFDCSHEMAAG 237

  Fly   250 IFRDAGEYNMTGEGHVWIVTEQALF---------------------SNNT--------------- 278
            |.:.|....|..|.:.:|.|...||                     :.||
Human   238 ILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQ 302

  Fly   279 ----PDGVLGLQLEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESGKRLFQ 339
                ||.  ||......:|...:.|:|:|::.|::: ....|::..  .| :....|..|.|...
Human   303 APPKPDS--GLLDGFMTTDAALMYDAVHVVSVAVQQ-FPQMTVSSL--QC-NRHKPWRFGTRFMS 361

  Fly   340 YLKSRNITGETGQVAFD-DNGDRIYAGYDVINIREQQKKHVVGKFSYDSMRAKMRMRINDSEIIW 403
            .:|..:..|.||::.|: .||.|.....|||:::|:..:. :|.:...|       .:|.:|
Human   362 LIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEK-IGTWDPAS-------GLNMTE--- 415

  Fly   404 PGKQRRKPEGI---MIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCC 465
              .|:.||..|   :....|.:.||.|:|:|..::  .|:          ||:.|     :.|
Human   416 --SQKGKPANITDSLSNRSLIVTTILEEPYVLFKK--SDK----------PLYGN-----DRF-- 459

  Fly   466 RGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAP 530
            .|||||||.|||..:.|||::.|..||::|.....|.        :|.|::.||::.:||:.|||
Human   460 EGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANG--------QWNGMVRELIDHKADLAVAP 516

  Fly   531 LTINPERAEYIEFSKPFKYQGITILEKKPSRSST-LVSFLQPFSNTLWILVMVSVHVVALVLYLL 594
            |.|...|.:.|:|||||...||:||.:||:.::. :.|||.|.|..:|:.::::...|:.||:::
Human   517 LAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVI 581

  Fly   595 DRFSPFGRFK--LSHSDSN-EEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAM 656
            .||||:..:.  ..:.||: .|....|.::.||..|.|:..| .|..|::.|.|::|.:|..|.:
Human   582 ARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTL 645

  Fly   657 IIVASYTANLAAFLVLERPKTKLSGINDARLRNTME------NLTCATVKGSSVDMYFRRQVELS 715
            ||::||||||||||.:||.::.:...:|...:..:|      ..|....|.|.:..|.:....:|
Human   646 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMS 710

  Fly   716 NMYRT--MEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYGIGLQ 778
            :..::  :::|     |:.||.|.... .||:.:|:.:|:...::|.|...|.|....|||:|..
Human   711 SRRQSVLVKSN-----EEGIQRVLTSD-YAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTP 769

  Fly   779 KGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNC-ELFEKTPNTLGLKNMAGVFILVGVG 842
            .|||:.|.:|:|||:..|.|.:..:.::| :.|:   .| |...|..:.||::|:.|:||::..|
Human   770 MGSPYRDKITIAILQLQEEGKLHMMKEKW-WRGN---GCPEEESKEASALGVQNIGGIFIVLAAG 830

  Fly   843 IAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKR-------KTIRASLAMQRQYNVG 900
            :...|.:.:.|.:||.   ||..:|              |||       :.:|.||..||:..
Human   831 LVLSVFVAVGEFLYKS---KKNAQL--------------EKRSFCSAMVEELRMSLKCQRRLK-- 876

  Fly   901 LNSTHAP 907
                |.|
Human   877 ----HKP 879

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.