Protein Alignment Nmdar1 and GRIK1

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Alignment Length: 943
• Identity: 241/943 - (25%)
• Similarity: 412/943 - (43%)
• Gaps: 140/943 - (14%)

  Fly    36 PSTYNIGGVLSNSDSEE------HFSTTIKHLNFDQQYVPRKVTYYD-KTIRMDKNPIKTVFNVC 93
            |....|||:....::|.      .|...:..:|.::..:|.....|| :.|.: .:..:.....|
Human    34 PQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINL-FDSFEASRRAC 97

  Fly    94 DKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYY 158
            |:|..........||..     |.:||........:|.|....:..:..:|::.  ::...|.|.
Human    98 DQLALGVAALFGPSHSS-----SVSAVQSICNALEVPHIQTRWKHPSVDNKDLF--YINLYPDYA 155

  Fly   159 HQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESF 223
            ..:...|:::.::.:..|.::: .|:.|...|.........|...:.:|.......:.:|.|:
Human   156 AISRAILDLVLYYNWKTVTVVY-EDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLK-- 217

  Fly   224 TEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFS-----------NN 277
                 :||..:....:...|.|.|..|.:......|..|.:.:..|...||:           |.
Human   218 -----EMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNM 277

  Fly   278 TPDGVLGLQLEHAHS---------------------------DKGHIRDSVYVLASAIKEMISNE 315
            |...:|.:...|..|                           :...:.|:||::|.| ....|..
Human   278 TGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIA-SHRASQL 341

  Fly   316 TIAEAPKDCGDSAVNWESGKRLFQYLKSRNITGETGQVAFD-DNGDRIYAGYDVINIREQQKKHV 379
            |::..  .| .....|..|.|....:|.....|.||.:.|: .||.|.....|:|:::|:..:..
Human   342 TVSSL--QC-HRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKA 403

  Fly   380 VGKFSYDSMRAKMRMRI--NDSEIIWPGKQRRKPEGI---MIPTHLRLLTIEEKPFVYVRRMGDD 439
            .|:.|....:...::.|  ::|.:......:.|...|   :....|.:.||.|:|:|..|:  .|
Human   404 AGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRK--SD 466

  Fly   440 EFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTG 504
            :          ||:.|     :.|  .|||:|||.|||..:.|.||:.|.|||::|   .:|:.|
Human   467 K----------PLYGN-----DRF--EGYCLDLLKELSNILGFIYDVKLVPDGKYG---AQNDKG 511

  Fly   505 AMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSST-LVSF 568
                  ||.|::.||::.|||:.||||||...|.:.|:|||||...||:||.:||:.::. :.||
Human   512 ------EWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSF 570

  Fly   569 LQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFK--LSHSDSN-EEKALNLSSAVWFAWGVLL 630
            |.|.|..:|:.|:::...|:.||:::.||:|:..:.  ..:.||: .|....|.::.||..|.|:
Human   571 LNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALM 635

  Fly   631 NSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTME--- 692
            ..| .|..|::.|.|::|.:|..|.:||::||||||||||.:||.::.:...:|...:..:|
Human   636 QQG-SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGA 699

  Fly   693 ---NLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYE 754
               ..|....|.|.:..|.:....:|:..:|....|   :::.||.|.... .|.:.:|:.:||.
Human   700 VRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRN---SDEGIQRVLTTD-YALLMESTSIEYV 760

  Fly   755 ASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNC-E 818
            ..::|.|...|.|....|||:|...|||:.|.:|:|||:..|.|.:..:.::| :.|:   .| |
Human   761 TQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKW-WRGN---GCPE 821

  Fly   819 LFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEK 883
            ...|..:.||::|:.|:||::..|:...|.:.|.|.||     |.:|..||.           :|
Human   822 EDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIY-----KSRKNNDIE-----------QK 870

  Fly   884 RKTIRASLAMQRQYNVGLNSTHAPGTISLAVDK 916
            .|:.|.....:.:...     |.....||.|:|
Human   871 GKSSRIRFYFRNKVRF-----HGRKKQSLGVEK 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	74/415 (18%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	138/411 (34%)
		CaM_bdg_C0	854..882	CDD:402271	6/27 (22%)
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	74/412 (18%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	136/402 (34%)