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Protein Alignment Nmdar1 and GRIK1

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	943	Identity:	241/943 - (25%)
Similarity:	412/943 - (43%)	Gaps:	140/943 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PSTYNIGGVLSNSDSEE------HFSTTIKHLNFDQQYVPRKVTYYD-KTIRMDKNPIKTVFNVC 93
            |....|||:....::|.      .|...:..:|.::..:|.....|| :.|.: .:..:.....|
Human    34 PQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINL-FDSFEASRRAC 97

  Fly    94 DKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYY 158
            |:|..........||..     |.:||........:|.|....:..:..:|::.  ::...|.|.
Human    98 DQLALGVAALFGPSHSS-----SVSAVQSICNALEVPHIQTRWKHPSVDNKDLF--YINLYPDYA 155

  Fly   159 HQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESF 223
            ..:...|:::.::.:..|.::: .|:.|...|.........|...:.:|.......:.:|.|:
Human   156 AISRAILDLVLYYNWKTVTVVY-EDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLK-- 217

  Fly   224 TEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFS-----------NN 277
                 :||..:....:...|.|.|..|.:......|..|.:.:..|...||:           |.
Human   218 -----EMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNM 277

  Fly   278 TPDGVLGLQLEHAHS---------------------------DKGHIRDSVYVLASAIKEMISNE 315
            |...:|.:...|..|                           :...:.|:||::|.| ....|..
Human   278 TGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIA-SHRASQL 341

  Fly   316 TIAEAPKDCGDSAVNWESGKRLFQYLKSRNITGETGQVAFD-DNGDRIYAGYDVINIREQQKKHV 379
            |::..  .| .....|..|.|....:|.....|.||.:.|: .||.|.....|:|:::|:..:..
Human   342 TVSSL--QC-HRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKA 403

  Fly   380 VGKFSYDSMRAKMRMRI--NDSEIIWPGKQRRKPEGI---MIPTHLRLLTIEEKPFVYVRRMGDD 439
            .|:.|....:...::.|  ::|.:......:.|...|   :....|.:.||.|:|:|..|:  .|
Human   404 AGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRK--SD 466

  Fly   440 EFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTG 504
            :          ||:.|     :.|  .|||:|||.|||..:.|.||:.|.|||::|   .:|:.|
Human   467 K----------PLYGN-----DRF--EGYCLDLLKELSNILGFIYDVKLVPDGKYG---AQNDKG 511

  Fly   505 AMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSST-LVSF 568
                  ||.|::.||::.|||:.||||||...|.:.|:|||||...||:||.:||:.::. :.||
Human   512 ------EWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSF 570

  Fly   569 LQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFK--LSHSDSN-EEKALNLSSAVWFAWGVLL 630
            |.|.|..:|:.|:::...|:.||:::.||:|:..:.  ..:.||: .|....|.::.||..|.|:
Human   571 LNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALM 635

  Fly   631 NSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTME--- 692
            ..| .|..|::.|.|::|.:|..|.:||::||||||||||.:||.::.:...:|...:..:|
Human   636 QQG-SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGA 699

  Fly   693 ---NLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYE 754
               ..|....|.|.:..|.:....:|:..:|....|   :::.||.|.... .|.:.:|:.:||.
Human   700 VRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRN---SDEGIQRVLTTD-YALLMESTSIEYV 760

  Fly   755 ASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNC-E 818
            ..::|.|...|.|....|||:|...|||:.|.:|:|||:..|.|.:..:.::| :.|:   .| |
Human   761 TQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKW-WRGN---GCPE 821

  Fly   819 LFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEK 883
            ...|..:.||::|:.|:||::..|:...|.:.|.|.||     |.:|..||.           :|
Human   822 EDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIY-----KSRKNNDIE-----------QK 870

  Fly   884 RKTIRASLAMQRQYNVGLNSTHAPGTISLAVDK 916
            .|:.|.....:.:...     |.....||.|:|
Human   871 GKSSRIRFYFRNKVRF-----HGRKKQSLGVEK 898

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.