DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nmdar1 and GRID2

DIOPT Version :9

Sequence 1:NP_730940.1 Gene:Nmdar1 / 40665 FlyBaseID:FBgn0010399 Length:997 Species:Drosophila melanogaster
Sequence 2:XP_011530195.2 Gene:GRID2 / 2895 HGNCID:4576 Length:1035 Species:Homo sapiens


Alignment Length:891 Identity:220/891 - (24%)
Similarity:378/891 - (42%) Gaps:185/891 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 PIKTVFNVCDKLIENRVYAVVVSHEQTS-GDLSPAAVSYTSGFYSIPVIGISSRDAAF------- 141
            |.||    |: |:...:.|:|.|...|| |.|...|.:     ..||.:.|....|..       
Human    91 PQKT----CE-LMNQGILALVSSIGCTSAGSLQSLADA-----MHIPHLFIQRSTAGTPRSGCGL 145

  Fly   142 --SDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDV 204
              |::|...:.....|.|.|  ||.|.:::.:|:.|.||.:.|:.|.|.|        |.:.|.|
Human   146 TRSNRNDDYTLSVRPPVYLH--DVILRVVTEYAWQKFIIFYDSEYDIRGI--------QEFLDKV 200

  Fly   205 DVRATVELIVEFEPKLESFTEHLID----------MKTAQSRVYLMYASTEDAQVIFRDAGEYNM 259
            ..:.....:.:.|..:......|.|          ..|.:..:.:|..:|  |:....:..|.|:
Human   201 SQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPAT--AKSFITEVVETNL 263

  Fly   260 TGEGHVWIV---------------------------------TEQALFSNN--------TPDGVL 283
            ......||:                                 ..|..|..|        .|....
Human   264 VAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPF 328

  Fly   284 GLQLEHAHSDKGHIRDSVYVLASAI-KEMISNETIAEAPKDC-GDSAVNWESGKRLFQYLKSRNI 346
            ...:|.::.   :|.|:|.:||:|. |::...:..:.|...| ..::..|:.|:.:.:.:|...:
Human   329 AQNMEISNL---YIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGV 390

  Fly   347 TGETGQVAFDDNGDRIYAGYDVI--NIREQQKKHVVGKFSYDSMRAKMRMRINDSE-IIWP---- 404
            :|.||::.|.:||......::::  |..|:     :|:    .:|...|:|...|. .|||    
Human   391 SGLTGELEFGENGGNPNVHFEILGTNYGEE-----LGR----GVRKNERIRPQGSTGKIWPQLGC 446

  Fly   405 ---------GKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATA 460
                     ....:|.|..|....||::|:.|:|||.|    .:....:|.:             
Human   447 WNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMV----SENVLGKPKK------------- 494

  Fly   461 NEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERAD 525
                .:|:.||:|..||..:.|.|::.::||.::|.   ....|.      |.||:||||.:|||
Human   495 ----YQGFSIDVLDALSNYLGFNYEIYVAPDHKYGS---PQEDGT------WNGLVGELVFKRAD 546

  Fly   526 MIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALV 590
            :.::.|||.|:|...::|:..:....:.:|.::..::..:.:.|.||..:||..:..:|.:|.|:
Human   547 IGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLL 611

  Fly   591 LYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFA 655
            :|||:..:| .|.::....|.     .|.:::||.:|..:..| ||....:.:.|::...|..||
Human   612 VYLLNWLNP-PRLQMGSMTST-----TLYNSMWFVYGSFVQQG-GEVPYTTLATRMMMGAWWLFA 669

  Fly   656 MIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMY--------FRRQV 712
            :|:::||||||||||.:.|.::.:..:.|.   :....:...||..|:|..:        |.|..
Human   670 LIVISSYTANLAAFLTITRIESSIQSLQDL---SKQTEIPYGTVLDSAVYEHVRMKGLNPFERDS 731

  Fly   713 ELSNMYRTM-----EANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEA--SKDCELVTAGELFGR 770
            ..|.|:|.:     ..||...::..||.||.|. .||:||::.|||.|  ..||...|.|.....
Human   732 MYSQMWRMINRSNGSENNVLESQAGIQKVKYGN-YAFVWDAAVLEYVAINDPDCSFYTIGNTVAD 795

  Fly   771 SGYGIGLQKGSPWTDAVTLAILEFHESGFMEKL-DKQWIFHGHVQQNCELF-----EKTPNTLGL 829
            .||||.||.|||:.|..:..|||..::|.|:.| .|.|..:|    .|:|:     ::....|.:
Human   796 RGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNG----QCDLYSSVDTKQKGGALDI 856

  Fly   830 KNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKK------QKRLDI 869
            |:.||||.::..||.....:.::|..:.|.:..:      .|.:|:
Human   857 KSFAGVFCILAAGIVLSCFIAMLETWWNKRKGSRVPSKEDDKEIDL 902

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nmdar1NP_730940.1 PBP1_iGluR_NMDA_NR1 12..405 CDD:107374 80/398 (20%)
ANF_receptor 58..371 CDD:279440 70/350 (20%)
PBP2_iGluR_NMDA_Nr1 417..818 CDD:270437 123/416 (30%)
HisJ 451..>558 CDD:223904 29/106 (27%)
Periplasmic_Binding_Protein_Type_2 <516..651 CDD:304360 36/134 (27%)
Lig_chan 575..838 CDD:278489 90/283 (32%)
CaM_bdg_C0 854..882 CDD:287524 3/22 (14%)
GRID2XP_011530195.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000021
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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