DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nmdar1 and Grin2a

DIOPT Version :9

Sequence 1:NP_730940.1 Gene:Nmdar1 / 40665 FlyBaseID:FBgn0010399 Length:997 Species:Drosophila melanogaster
Sequence 2:NP_036705.3 Gene:Grin2a / 24409 RGDID:2737 Length:1464 Species:Rattus norvegicus


Alignment Length:1137 Identity:300/1137 - (26%)
Similarity:495/1137 - (43%) Gaps:248/1137 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 LLVAPI-----DAAQRHTASDNPSTYNIGGVLSNSDSEEHFSTTIKHLNFDQQYVPRKVTYYDKT 78
            |||.|.     |.||...|...|...||..:|.:|    |..|..:..|.   :.|.:.|    .
  Rat     9 LLVLPALLVWRDPAQNAAAEKGPPALNIAVLLGHS----HDVTERELRNL---WGPEQAT----G 62

  Fly    79 IRMDKNPIKTVFN----------VCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYS----I 129
            :.:|.|.:..:.|          |||.:...|::.:|.     ..|....||:....|.|    |
  Rat    63 LPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVF-----GDDTDQEAVAQMLDFISSQTFI 122

  Fly   130 PVIGI-SSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRF 193
            |::|| .......:||:...:|.:.......||.|.|:::..:.:....::.:.....|..:...
  Rat   123 PILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYRDFISFI 187

  Fly   194 QTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYN 258
            :||....:...|::..:.|...||   ::.|:  :.:|...|.|.|:|.|.::|.:|..:|....
  Rat   188 KTTVDNSFVGWDMQNVITLDTSFE---DAKTQ--VQLKKIHSSVILLYCSKDEAVLILSEARSLG 247

  Fly   259 MTGEGHVWIVTEQALFSNNT-------PDGVLGLQLEH-AHSDKGHIRDSVYVLASAIKEMISN- 314
            :||....|||  .:|.|.||       |.|::.:..:. .:|.:..:||.:.:|.:|...|:.. 
  Rat   248 LTGYDFFWIV--PSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGLGILTTAASSMLEKF 310

  Fly   315 ETIAEAPKDCGDSAVNWESG-KRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKH 378
            ..|.||...|...|...|:. ..|.|::.  |:|.:...::|.:.|.:::....||.:.:.::..
  Rat   311 SYIPEAKASCYGQAEKPETPLHTLHQFMV--NVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWE 373

  Fly   379 VVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIP--THLRLLTIEEKPFVYVRRMGDDEF 441
            .|||:...::..:        ..:||   |.|......|  .||.::|:||.|||.|..:.....
  Rat   374 KVGKWENQTLSLR--------HAVWP---RYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTE 427

  Fly   442 RCEPDERPCPLFNNSDATANE-----FCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRN 501
            .|..:..||..|...:.:.||     .||:|:|||:|.:||:.:.|||||.|..:|:.|..:  |
  Rat   428 TCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKV--N 490

  Fly   502 NTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLV 566
            |.        |.|:|||:|.:||.|.|..||||.||:|.::||.||...||:::   .|||:..|
  Rat   491 NV--------WNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVM---VSRSNGTV 544

  Fly   567 S---FLQPFSNTLWILVMVSVHVV-ALVLYLLDRFSPFG------RFKLSHSDSNEEKALNLSSA 621
            |   ||:|||.::|:::.|.:.:| |:.:::.:.|||.|      :.|..|..|     ..:..|
  Rat   545 SPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPS-----FTIGKA 604

  Fly   622 VWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDAR 686
            :|..||::.|:.:....|:..:::::..|||.||:|.:||||||||||::.|....:::|::|.:
  Rat   605 IWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKK 669

  Fly   687 LRNTME---NLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDS 748
            .:...:   .....||...|.:...|......:.|  |...|....|.|:..:|.|||.|||:|:
  Rat   670 FQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQY--MTRFNQRGVEDALVSLKTGKLDAFIYDA 732

  Fly   749 SRLEYEASKD--CELVT--AGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIF 809
            :.|.|:|.:|  |:|||  :|.:|..:||||.|||||||...:.||:|:|...|.||:|:..|: 
  Rat   733 AVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWL- 796

  Fly   810 HG--HVQQNCELFEKTPNTLGLKNMAGVFILVGVGIA--------------------GGV----- 847
            .|  |.::|    |...:.|.:.||||||.::...:|                    .||     
  Rat   797 TGICHNEKN----EVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRP 857

  Fly   848 GLI------IIEVIYKKHQVKKQK--------------------------------RLDIARHAA 874
            ||:      |...|:..|..:|:|                                |:|..:.|.
  Rat   858 GLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAKNISNMSNMNSSRMDSPKRAT 922

  Fly   875 D-KWRGTI--------------------------------------EKRKTIRASLAMQRQYNVG 900
            | ..||::                                      .:.|...::...|.|:.:.
  Rat   923 DFIQRGSLIVDMVSDKGNLIYSDNRSFQGKDSIFGDNMNELQTFVANRHKDNLSNYVFQGQHPLT 987

  Fly   901 LNSTHAPGTISLAV--DKRRYPRLGQRLGPERAWPGDAADVLRIRRPYELGNP-GQSPKVMAANQ 962
            ||.:: |.|:.:||  :.:...|      |.:.|   ...:..:|:.....|| .|..:..|.|:
  Rat   988 LNESN-PNTVEVAVSTESKGNSR------PRQLW---KKSMESLRQDSLNQNPVSQRDEKTAENR 1042

  Fly   963 PGMPMPMLGKTRPQQSVLPPRYSPGYTSDVSH 994
                         ..|:..|||.|   .:|:|
  Rat  1043 -------------THSLKSPRYLP---EEVAH 1058

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Nmdar1NP_730940.1 PBP1_iGluR_NMDA_NR1 12..405 CDD:107374 94/415 (23%)
ANF_receptor 58..371 CDD:279440 75/337 (22%)
PBP2_iGluR_NMDA_Nr1 417..818 CDD:270437 154/426 (36%)
HisJ 451..>558 CDD:223904 45/111 (41%)
Periplasmic_Binding_Protein_Type_2 <516..651 CDD:304360 48/144 (33%)
Lig_chan 575..838 CDD:278489 94/278 (34%)
CaM_bdg_C0 854..882 CDD:287524 10/98 (10%)
Grin2aNP_036705.3 PBP1_iGluR_NMDA_NR2 32..392 CDD:107373 86/395 (22%)
PBP2_iGluR_NMDA_Nr2 403..802 CDD:270436 151/419 (36%)
HisJ <458..>541 CDD:223904 42/95 (44%)
Glutamate binding. /evidence=ECO:0000269|PubMed:16281028, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY 511..513 0/1 (0%)
Lig_chan 556..828 CDD:278489 94/283 (33%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1 599..620 5/20 (25%)