DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and Grin1

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001257531.1	Gene:	Grin1 / 24408	RGDID:	2736	Length:	959	Species:	Rattus norvegicus

Alignment Length:	954	Identity:	436/954 - (45%)
Similarity:	617/954 - (64%)	Gaps:	67/954 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ASDNPSTYNIGGVLSNSDSEEHFSTTIKHLNFDQQYVPRKVTYYDKTIRMDKNPIKTVFNVCDKL 96
            |:.:|...|||.|||....|:.|...:...|  :::...|:.....::....|.|:...:||:.|
  Rat    20 AACDPKIVNIGAVLSTRKHEQMFREAVNQAN--KRHGSWKIQLNATSVTHKPNAIQMALSVCEDL 82

  Fly    97 IENRVYAVVVSHEQTSGD-LSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQ 160
            |.::|||::|||..|..| .:|..||||:|||.|||:|:::|.:.:|||:||:|||||||||.||
  Rat    83 ISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQ 147

  Fly   161 ADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQT--------TSQTYYDDVDVRA-------TV 210
            :.||.||:..:.:..:|::.|.|.:|||...|.:|        :.:..|:::|..:       ..
  Rat   148 SSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKSKKRNYENLDQLSYDNKRGPKA 212

  Fly   211 ELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFS 275
            |.:::|:|..::.|..|::.:..::||.::.||.:||..::|.|...||||.|:||:|.|:.:..
  Rat   213 EKVLQFDPGTKNVTALLMEARELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG 277

  Fly   276 N---NTPDGVLGLQLEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESG--- 334
            |   ..|||::||||.:..::..||.|:|.|:|.|:.|::..|.|.:.|:.|..:...|::|
  Rat   278 NALRYAPDGIIGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLF 342

  Fly   335 KRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHV-VGKFSYDSMRAKMRMRIND 398
            ||:.  :.|:...|.||:|.|:::|||.:|.|.::|:  |.:|.| ||.::      ...:..||
  Rat   343 KRVL--MSSKYADGVTGRVEFNEDGDRKFANYSIMNL--QNRKLVQVGIYN------GTHVIPND 397

  Fly   399 SEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVR-RMGD----DEFRCEPDERP-----CPLF 453
            .:|||||.:..||.|..:.|.|:::||.::|||||: .|.|    :||....|  |     |...
  Rat   398 RKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGD--PVKKVICTGP 460

  Fly   454 NNSDATANEF----CCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTG 514
            |::...:...    ||.|:||||||:|::.:||||::.|..||:||.....||:.    :|||.|
  Rat   461 NDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSN----KKEWNG 521

  Fly   515 LIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWIL 579
            ::|||::.:|||||||||||.|||:||||||||||||:|||.||....|||.||:|||.:|||:|
  Rat   522 MMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLL 586

  Fly   580 VMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSA 644
            |.:||||||::||||||||||||||: :|:..||.||.||||:||:||||||||||||.||||||
  Rat   587 VGLSVHVVAVMLYLLDRFSPFGRFKV-NSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSA 650

  Fly   645 RVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFR 709
            |:||||||||||||||||||||||||||:||:.:::||||.||||..:....||||.||||:|||
  Rat   651 RILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFR 715

  Fly   710 RQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYG 774
            ||||||.|||.||.:||.:|.:|||.|:..||.||||||:.||:|||:.|:|||.||||.|||:|
  Rat   716 RQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFG 780

  Fly   775 IGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPNTLGLKNMAGVFILV 839
            ||::|.|||...|:|:||:.||:||||.|||.|:.:    |.|:.....|.||..:||||||:||
  Rat   781 IGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRY----QECDSRSNAPATLTFENMAGVFMLV 841

  Fly   840 GVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLNST 904
            ..||..|:.||.||:.||:|:..::|::.:|..|.:.||..::.||:.||....:::      :|
  Rat   842 AGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKK------AT 900

  Fly   905 HAPGTISLAVD-KRRYPRLGQRLGPERAWPGDAADVLRIRRPYE 947
            ....|.:||.. |||........|..|....:..|.:..||..|
  Rat   901 FRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKDTVLPRRAIE 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	137/395 (35%)
		ANF_receptor	58..371	CDD:279440	116/334 (35%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	250/414 (60%)
		HisJ	451..>558	CDD:223904	58/110 (53%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	100/134 (75%)
		Lig_chan	575..838	CDD:278489	176/262 (67%)
		CaM_bdg_C0	854..882	CDD:287524	8/27 (30%)
Grin1	NP_001257531.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	135/390 (35%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	250/414 (60%)
		CaM_bdg_C0	856..884	CDD:402271	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335287
Domainoid	1	1.000	356	1.000	Domainoid score	I955
eggNOG	1	0.900	-	-		E1_KOG4440
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7187
Inparanoid	1	1.050	779	1.000	Inparanoid score	I502
OMA	1	1.010	-	-		QHG49285
OrthoDB	1	1.010	-	-		D108757at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		oto96597
orthoMCL	1	0.900	-	-		OOG6_107231
Panther	1	1.100	-	-	LDO	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810