Protein Alignment Nmdar1 and Grin3a

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: NP_612555.1
• Gene: Grin3a / 191573
• RGDID: 621704
• Length: 1135
• Species: Rattus norvegicus
• Alignment Length: 985
• Identity: 250/985 - (25%)
• Similarity: 439/985 - (44%)
• Gaps: 177/985 - (17%)

  Fly    84 NPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGI-------------- 134
            :|...:.:||..::...|.| :::..|:.|::  ..:...|....|||:.|
  Rat   176 DPFSFLQSVCHTVVVQGVSA-LLAFPQSQGEM--MELDLVSSVLHIPVLSIVRHEFPRESQNPLH 237

  Fly   135 ---SSRDAAFSDKNIHVSFLRTVPPYYH------QADVW--------LEMLSHFAYTKVIIIHSS 182
               |..::..||.::.||.| |:..:|:      |.| |        .|..|.|....||.|.::
  Rat   238 LQLSLENSLSSDADVTVSIL-TMNNWYNFSLLLCQED-WNITDFLLLTENNSKFHLESVINITAN 300

  Fly   183 DTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDA 247
            .:..:.:|...|....      ::|.:...:|.|...::|..:
  Rat   301 LSSTKDLLSFLQVQMD------NIRNSTPTMVMFGCDMDSIRQ---------------------- 337

  Fly   248 QVIFRDAGEYNMTGEGHVWIVTEQALFSNNTPDGV-LGLQLEHAHSDKG----HIRDSVYVLASA 307
              ||..:.::.::.....|::.:.........:|: ||| :.|..:.:.    :::|::.::|.|
  Rat   338 --IFEMSTQFGLSPPELHWVLGDSQNVEELRTEGLPLGL-IAHGKTTQSVFEYYVQDAMELVARA 399

  Fly   308 I--KEMISNE-TIAEAPKDCGD-SAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDV 368
            :  ..||..| .:..:..:|.| ...|..||:.|.::|.:....|.:|.:.        ..|..:
  Rat   400 VATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIK--------VKGSTI 456

  Fly   369 INIREQQKKHVVGKFSYDSMRAKMRMRIN---------DSEIIWPGKQRRKPEGIMIPT--HLRL 422
            |:   .:....:....:|.|...|..|:.         ||. |||.:.:|.......|.  |||:
  Rat   457 IS---SENNFFIWNLQHDPMGKPMWTRLGSWQGGRIVMDSG-IWPEQAQRHKTHFQHPNKLHLRV 517

  Fly   423 LTIEEKPFVYVRRMGDDEFRCEPDERPC--PLFNNS--------------DATANEF--CCRGYC 469
            :|:.|.|||:.|.: |||..| |..:.|  |:.|:|              |....:|  ||.|||
  Rat   518 VTLIEHPFVFTREV-DDEGLC-PAGQLCLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYC 580

  Fly   470 IDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTIN 534
            ||||.:|::.:||.:||.:..||::|.:  :|.        .||||:|:|::..|:|.|...:||
  Rat   581 IDLLEQLAEDMNFDFDLYIVGDGKYGAW--KNG--------HWTGLVGDLLSGTANMAVTSFSIN 635

  Fly   535 PERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSP 599
            ..|::.|:|:.||....:.||.:....::.:.:|:.|...|:|:.:.|::|:.|:.|.|.:..||
  Rat   636 TARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSP 700

  Fly   600 FGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTA 664
            ||   ::....|..|..:.|||:...:.:|.........|:.::.|.|..:||.|.|..:::|||
  Rat   701 FG---MTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTA 762

  Fly   665 NLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATA 729
            ||||.:|.|:...:||||:|.:|.:..:.....||:.||.:.|.|:  ....|:..|...|....
  Rat   763 NLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQ--SFPEMHEYMRRYNVPAT 825

  Fly   730 EQAIQDVKKG--KLMAFIWDSSRLEYEAS--KDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLA 790
            ...:|.:|..  ||.|||.|.:.|:||.|  .||:|:|.|:.|...||||||...||.|..::..
  Rat   826 PDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISEL 890

  Fly   791 ILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPN-TLGLKNMAGVFILVGVGIAGGVGLIIIEV 854
            |.::...|||:.|..:|  :..|......|..|.. .:|:|:.:|:|:|:.:|.    ||.|:..
  Rat   891 ISQYKSHGFMDVLHDKW--YKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGF----GLSILTT 949

  Fly   855 IYKKH--------QVKKQKRLDIARHAADKWRGTI------EKR---KTIRASLAMQRQYNVGLN 902
            | .:|        ::|.:.:|....|.:.::...:      ||:   ||.|...:..|::..
  Rat   950 I-GEHIVHRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPRSKTKRVEKSRWRRWTC--- 1010

  Fly   903 STHAPGTISLAVDKRRYPRLGQRLGPERAWPGDAADVLR-IRRPYELGN-PGQSPKVMAANQPGM 965
            .|.....:||      :||  ..|||::....:.:::.. .:|.|...: .||:.....|:| .:
  Rat  1011 KTEGDSELSL------FPR--SNLGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQAHQ-DI 1066

  Fly   966 PMPMLGKTRP 975
            |:|...:..|
  Rat  1067 PLPQRRRELP 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	68/369 (18%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	141/424 (33%)
		CaM_bdg_C0	854..882	CDD:402271	5/41 (12%)
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	40..496	CDD:380600	66/367 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..117
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	139/414 (34%)
		Lig_chan	674..941	CDD:459656	89/273 (33%)
		PPP2CB binding site. /evidence=ECO:0000269|PubMed:11588171	951..987		4/35 (11%)
		GIT1-binding. /evidence=ECO:0000269|PubMed:24297929	1082..1115