Protein Alignment Nmdar1 and glr-6

DIOPT Version :9

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: NP_741822.2
• Gene: glr-6 / 180955
• WormBaseID: WBGene00001617
• Length: 844
• Species: Caenorhabditis elegans
• Alignment Length: 887
• Identity: 200/887 - (22%)
• Similarity: 373/887 - (42%)
• Gaps: 200/887 - (22%)

  Fly    83 KNPIKTVFNVC-----DKLIENR---------VYAVVVSHEQTSG---DLSPAAVSYTSGFYSIP 130
            ::.::|..|:.     :::::.|         ..|:..|||..:.   ||:.:.||.
 Worm    31 EHSVRTAVNIIVPRINEQIVKTRGACFITHTSFIALKNSHEDLNTKICDLANSEVSV-------- 87

  Fly   131 VIGISSRDAA------FSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAI 189
            :||:..|::.      .::.||........|.|..:....|.:.....|::::         ..:
 Worm    88 IIGVVDRESGSIIEEQCAELNILFIHYYWTPGYQKKQQTSLNLYPSMEYSQLM---------ERL 143

  Fly   190 LGRFQTTSQTY-YDDVDV-RATVELIVEFEPKLESFTEHLID---MKTA---------------Q 234
            :..::..:..| |.:.|. :..:|.:...|........|.:|   |.||               :
 Worm   144 INLWRWDNFVYIYSNYDAPKQLIETLSRLEKSPALLRAHTLDDSMMATALALRDTCDRNRCWPKK 208

  Fly   235 SRVYLMYASTEDAQVIFRDAG-EYNMTGEGHVWIVTEQAL------FSNNTPDGVLGLQLEHAHS 292
            :||.:..:..|  .:.|.||. :..|....:.:::|  ||      .|..|.:| :.:.|.....
 Worm   209 NRVLIELSPNE--TLTFFDASLKLGMISVHNWFLIT--ALDDLNDHLSQYTHNG-MRVSLLTVSK 268

  Fly   293 DKGHIRDSVYVLASAIKEMISNETIAEAP-------KD---------------------CGDSAV 329
            :|.:..|    ||..:.:|. .|.:|:.|       ||                     |||:
 Worm   269 EKWNQND----LAIKLPDMY-QEYLAKIPSNPRTPFKDFAFIFDSILLACQAGDRRIISCGDN-- 326

  Fly   330 NWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHV-------------VG 381
              |:.|: |:....:...|.||:::|:...|           |...:.|:             :.
 Worm   327 --EAVKK-FKLPIVKPFKGLTGKISFNGTSD-----------RSDSELHIWEMGITGAGLHTGIW 377

  Fly   382 KFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPD 446
            |.:::..:....:..|     .||........:.....|::.:|.|||:|..:.|.|...:.|
 Worm   378 KSTWEGSKELTMLAKN-----IPGTHEHYQASVRESRTLKVTSIHEKPYVIEKIMPDGRIKHE-- 435

  Fly   447 ERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKE 511
                                |:|:|||.:|::.::|.|.|.:..|.::|.  .:|.|      .|
 Worm   436 --------------------GFCVDLLDKLAEMLHFNYTLKIVKDNKYGE--RKNGT------DE 472

  Fly   512 WTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPS--RSSTLVSFLQPFSN 574
            |.|:|||::...|||.|||:|:...|.|.|:|:.||...||::|.::|:  .||:|..||.|.|.
 Worm   473 WDGMIGEILRGDADMAVAPITVTATRLEVIDFTDPFLQLGISMLMRQPNPKSSSSLTRFLWPLSA 537

  Fly   575 TLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTP 639
            ::|....::..:.||::.:....||        .:|..|  ..:.::||:...:||.:|.|...
 Worm   538 SVWTFSAIATVITALLVTVAAVLSP--------KESTAE--FKIQNSVWYLVCILLRAGSGYNC- 591

  Fly   640 RSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSV 704
            ::.:.|::..||..|.::::|.||||.||.|.::|.....:...:  |.|..|....:.:.||::
 Worm   592 QAGATRLISAVWWSFTLVLIAQYTANFAALLTVDRKSMPFNSFEE--LGNQTEYNFGSILGGSTM 654

  Fly   705 DMYFRRQVE-LSNMYRTMEANN----YATAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTA 764
            ..:...::| ...::..|::..    ..|..:.:..|...|.: |:.:|:.|:|:.:::|.|...
 Worm   655 QFFKYSRIETFRRLWERMQSAEPSAFVGTNHEGVNRVLNEKYV-FLMESATLDYQVTQNCNLTRV 718

  Fly   765 GE-LFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELF--EKTPNT 826
            |. :.|.:||.|.|.|||.|.:.:|..||:.:|.|.:..|...|  ....||.|:..  |.....
 Worm   719 GNVVLGSNGYSIALPKGSKWREKLTRQILDLNEKGIILMLKNNW--WKKSQQECQSSEPEDLQTA 781

  Fly   827 LGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQV--KKQKR 866
            ||.:|:.|:|:|:.:|  .|:| ::..|:...|.:  :|.||
 Worm   782 LGAENVYGLFLLLALG--SGIG-VLCAVLEHTHFIFFEKNKR 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	69/412 (17%)
		ANF_receptor	58..371	CDD:279440	65/365 (18%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	113/408 (28%)
		HisJ	451..>558	CDD:223904	35/106 (33%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	41/136 (30%)
		Lig_chan	575..838	CDD:278489	68/270 (25%)
		CaM_bdg_C0	854..882	CDD:287524	5/15 (33%)
glr-6	NP_741822.2	PBP1_iGluR_non_NMDA-like	21..394	CDD:380591	69/410 (17%)
		PBP2_iGluR_Kainate	409..764	CDD:270432	111/400 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4386
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.860