DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and glr-8

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001368711.1	Gene:	glr-8 / 180924	WormBaseID:	WBGene00001619	Length:	547	Species:	Caenorhabditis elegans

Alignment Length:	650	Identity:	139/650 - (21%)
Similarity:	241/650 - (37%)	Gaps:	178/650 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 QLEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESGKRLFQYLKSRNITGET 350
            :.|:..:|...||....:|.|.      ||.:|..|:                        |..|
Worm     5 EFENTTADPNSIRTLNNILESI------NEKVAHPPQ------------------------TSLT 39

  Fly   351 GQVAFDDNGDRIYAGYDVINIREQQKKHVVGKFSYDSMRAK-MRMRINDSEIIWPGKQRRKPEGI 414
                 .|.||    .|.:.|     :||    ||...|:.: ::|
Worm    40 -----SDYGD----AYTLSN-----EKH----FSLSEMKGRTLKM-------------------- 66

  Fly   415 MIPTHLRLLTIEEKPFV-YVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGY----CIDLLI 474
            ::|.       .|.|:| ||                    |.|||...:   :||    .:::|.
Worm    67 VVPA-------IEPPYVNYV--------------------NFSDAAVTD---KGYGPGVVMEILK 101

  Fly   475 ELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAE 539
            |:.||:|.||::..:....:|.|          |...|||..|:||....|::.....:..:|:.
Worm   102 EIGKRLNLTYEILPALGSTWGEY----------LNGSWTGAFGQLVRGEVDLLAGGAIMEYDRSV 156

  Fly   540 YIEFSKPFKYQGITILEKKPSR--SSTLVSFLQPFSNTLWIL---VMVSVHVVALVLYLLDRFSP 599
            ..:.:.||:::...|:.:.|.:  ..||:...:|||..:|::   |::...|:.||:..:.|
Worm   157 IADLTYPFQFEPTGIMIRSPEKYEDDTLLIVTEPFSWEVWVITAAVILISGVIFLVMTNIIR--- 218

  Fly   600 FGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTA 664
                     ...||..:....::|..:.:.:..|:.| .|||:|.|||..:|...::.:.|::|.
Worm   219 ---------KVYEEMTVTPFESIWVFFSIFVQQGLPE-QPRSWSCRVLVALWWLASITLSATFTG 273

  Fly   665 NLAAFLVLERPKTKLSGIN-------DARLRNTM-ENLTCAT--VKGSSVDMYFRRQVELSNMYR 719
            :|.|...:::.......|:       ..:....| ||....|  :..|.:.:|.....|:...::
Worm   274 SLVALFAVDKTNVPFQNIDQLVRLVKQGKFEIVMDENSFTRTEMIARSKLPVYRDLWHEMIVNHK 338

  Fly   720 TMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYGIGLQKGSPWT 784
            ....|..|   :.:..|:.....|.:...:.|.:.|..||:::...:........|.|.|.|.::
Worm   339 VKYVNGIA---RGVAFVRANPGYALLGPMATLNFYAYSDCKVILFNDGILPVYLSIPLVKNSIYS 400

  Fly   785 DAVTLAILEFHESGFMEKLDKQWI--FHGHVQQNCELFEKTPNTLG------LKNMAGVF--ILV 839
            ...:..|.|..|.||.:|    ||  :..:|... ::.|....|:|      ||...|.|  .|.
Worm   401 PYFSTKIREMVERGFTQK----WIADYRSYVAMQ-KINECNSTTIGPKSYLDLKRAQGAFWVFLG 460

  Fly   840 GVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLNST 904
            |.|:  |:.|.:.|.|:|..:.|..|.               .|..|:...:|.. ..||..|||
Worm   461 GAGL--GLALFVGEFIFKFFREKMTKH---------------TKTTTVPPEVATV-SANVAENST 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	23/119 (19%)
		ANF_receptor	58..371	CDD:279440	16/84 (19%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	91/422 (22%)
		HisJ	451..>558	CDD:223904	27/110 (25%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	32/139 (23%)
		Lig_chan	575..838	CDD:278489	59/285 (21%)
		CaM_bdg_C0	854..882	CDD:287524	4/27 (15%)
glr-8	NP_001368711.1	PBP2_iGluR_ligand_binding	62..424	CDD:270219	91/441 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910